Patents by Inventor Leslie Krushel

Leslie Krushel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic internal ribosome entry sites and methods of identifying same
    Patent number: 7468275
    Abstract: Synthetic and isolated translational regulatory elements, including oligonucleotides that have translational enhancing activity, internal ribosome entry site (IRES) activity, or translational inhibitory activity, and multimers of such translational regulatory elements are provided. In addition, compositions that include such translational regulatory elements are provided, as are methods of using the translational regulatory elements.
    Type: Grant
    Filed: January 26, 2001
    Date of Patent: December 23, 2008
    Assignee: The Scripps Research Institute
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Stephen A. Chappell, Geoffrey Owens, Jason K. Pinkstaff, Leslie Krushel, Wei Zhou
  • Synthetic internal ribosome entry sites and methods of identifying same
    Publication number: 20040043468
    Abstract: Synthetic and isolated translational regulatory elements, including oligonucleotides that have translational enhancing activity, internal ribosome entry site (IRES) activity, or translational inhibitory activity, and multimers of such translational regulatory elements are provided. In addition, compositions that include such translational regulatory elements are provided, as are methods of using the translational regulatory elements.
    Type: Application
    Filed: November 27, 2002
    Publication date: March 4, 2004
    Inventors: Vincent P. Mauro, Gerald M. Edelman, Stephen A. Chappell, Geoffrey Owens, Jason K. Pinkstaff, Leslie Krushel, Wei Zhou
  • Inhibition of glial cell proliferation with N-CAM homophilic peptides
    Patent number: 5985822
    Abstract: Methods and compositions are disclosed that are useful for the inhibition of glial cell proliferation by means of binding inhibiting agents to neural cell adhesion (N-CAM) molecules present on the cell surface. Such inhibiting agents can be peptides derived from the homophilic binding region of N-CAM, monoclonal antibodies, polyclonal antibodies, Fab' fragments, and the like. Exemplary N-CAM homophilic peptides are 7 to 90 amino acid residues having a positively charged amino acid residue separated from a negatively charged amino acid residue by five intervening amino acid residues.
    Type: Grant
    Filed: May 8, 1995
    Date of Patent: November 16, 1999
    Assignee: The Scripps Research Institute
    Inventors: Gerald M. Edelman, Kathryn L. Crossin, Olaf Sporns, Leslie Krushel