Patents by Inventor Leslie Kushner

Leslie Kushner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Elastase inhibitors
    Publication number: 20030069187
    Abstract: Naturally occurring novel elastin derived oligopeptides, having the formula AFP, VPG and AGIP, are disclosed. The oligopeptides are strong competitive inhibitors of elastolytic serine proteases, particularly neutrophil elastases. The novel oligopeptides are useful in methods of inhibiting elastolytic serine protease and methods of detecting a disease characterized by elevated activity of elastolytic serine proteases. Methods for determining the severity of diseases characterized by elevated activity of elastolytic serine proteases are also disclosed.
    Type: Application
    Filed: October 5, 2001
    Publication date: April 10, 2003
    Inventors: Srinivasa K. Rao, Mahesh Mathrubutham, Leslie Kushner, Glenn R. Faust
  • Method for isolating inhibitors of protease activity
    Patent number: 6350586
    Abstract: The present invention provides an assay for detecting and quantifying protease that is sensitive, rapid, and capable of screening numerous samples of small volume. Also provided by the present invention is a method for diagnosing disorders associated with connective tissue destruction in a subject by detecting and quantifying a particular protease in a biological sample. Further provided by the present invention is a method of detecting inhibitors of the activity of a protease by detecting primary amines that are exposed by the enzymatic degradation of a protease substrate.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: February 26, 2002
    Assignee: Long Island Jewish Medical Center
    Inventors: Srinivasa K. Rao, Leslie Kushner, Mahesh Mathrubutham, Jon R. Cohen
  • Method for isolating inhibitors of protease activity
    Publication number: 20010012622
    Abstract: The present invention provides an assay for detecting and quantifying protease that is sensitive, rapid, and capable of screening numerous samples of small volume. Also provided by the present invention is a method for diagnosing disorders associated with connective tissue destruction in a subject by detecting and quantifying a particular protease in a biological sample. Further provided by the present invention is a method of detecting inhibitors of the activity of a protease by detecting primary amines that are exposed by the enzymatic degradation of a protease substrate.
    Type: Application
    Filed: March 5, 2001
    Publication date: August 9, 2001
    Inventors: Srinivasa K. Rao, Leslie Kushner, Mahesh Mathrubutham, Jon R. Cohen
  • Method for detecting proteases and uses thereof
    Patent number: 6197537
    Abstract: The present invention provides an assay for detecting and quantifying protease that is sensitive, rapid, and capable of screening numerous samples of small volume. Also provided by the present invention is a method for diagnosing disorders associated with connective tissue destruction in a subject by detecting and quantifying a particular protease in a biological sample. Further provided by the present invention is a method of detecting inhibitors of the activity of a protease by detecting primary amines that are exposed by the enzymatic degradation of a protease substrate.
    Type: Grant
    Filed: May 19, 1999
    Date of Patent: March 6, 2001
    Assignee: Long Island Jewish Medical Center
    Inventors: Srinivasa K. Rao, Leslie Kushner, Mahesh Mathrubutham, Jon R. Cohen
  • Method for isolating inhibitors of protease activity
    Patent number: 6017723
    Abstract: The present invention provides an assay for detecting and quantifying protease that is sensitive, rapid, and capable of screening numerous samples of small volume. Also provided by the present invention is a method for diagnosing disorders associated with connective tissue destruction in a subject by detecting and quantifying a particular protease in a biological sample. Further provided by the present invention is a method of detecting inhibitors of the activity of a protease by detecting primary amines that are exposed by the enzymatic degradation of a protease substrate.
    Type: Grant
    Filed: March 27, 1998
    Date of Patent: January 25, 2000
    Assignee: Long Island Jewish Medical Center
    Inventors: Srinivasa K. Rao, Leslie Kushner, Mahesh Mathrubutham, Jon R. Cohen