Patents by Inventor Leslie Lobel

Leslie Lobel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Virus-like particles for treatment of viral infections
    Patent number: 9434959
    Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.
    Type: Grant
    Filed: April 10, 2014
    Date of Patent: September 6, 2016
    Assignee: BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Leslie Lobel, Guy Gubi
  • VIRUS-LIKE PARTICLES FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20140248243
    Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.
    Type: Application
    Filed: April 5, 2012
    Publication date: September 4, 2014
    Applicant: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Leslie Lobel, Guy Gubi
  • VIRUS-LIKE PARTICLES FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20140213640
    Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.
    Type: Application
    Filed: April 10, 2014
    Publication date: July 31, 2014
    Applicant: Ben Gurion University of The Negev Research and Development Authority
    Inventors: Leslie Lobel, Guy Gubi
  • Virus-like particles for treatment of viral infections
    Patent number: 8153115
    Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: April 10, 2012
    Assignee: Ben-Gurion University of The Negev Research and Development Authority
    Inventors: Leslie Lobel, Guy Gubi
  • VIRUS-LIKE PARTICLES FOR TREATMENT OF VIRAL INFECTIONS
    Publication number: 20100291040
    Abstract: The invention provides virus-like particles for treatment of viral infections based on the virus causing the infection. The virus-like particles comprise the virus recombinant proteins that form a capsid, recombinant virus membrane proteins attached to the capsid and vRNA packaged within said capsid. The vRNA is generated from a DNA sequence encoding a polypeptide capable of specifically binding to a constant region of a nonstructural protein of the virus that is essential for propagation of the virus.
    Type: Application
    Filed: June 14, 2007
    Publication date: November 18, 2010
    Applicant: BEN-GU-RION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY
    Inventors: Leslie Lobel, Guy Gubi
  • Long-acting hormone and growth factor compositions and uses thereof
    Publication number: 20090093411
    Abstract: This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject, as well as methods for increasing vascularization in a tissue, particularly in ovarian tissue.
    Type: Application
    Filed: September 26, 2008
    Publication date: April 9, 2009
    Inventors: Joyce Lustbader, Leslie Lobel
  • Long-acting hormone and growth factor compositions and uses thereof
    Patent number: 7442684
    Abstract: This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject, as well as methods for increasing vascularization in a tissue, particularly in ovarian tissue.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: October 28, 2008
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Joyce Lustbader, Leslie Lobel
  • Long-acting hormone and growth factor compositions and uses thereof
    Patent number: 7173113
    Abstract: This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject, as well as methods for increasing vascularization in a tissue, particularly in ovarian tissue.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: February 6, 2007
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Joyce Lustbader, Leslie Lobel
  • Long-acting hormone and growth factor compositions and uses thereof
    Publication number: 20030216313
    Abstract: This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject, as well as methods for increasing vascularization in a tissue, particularly in ovarian tissue.
    Type: Application
    Filed: January 31, 2003
    Publication date: November 20, 2003
    Inventors: Joyce Lustbader, Leslie Lobel
  • Long-acting hormone and growth factor compositions and uses thereof
    Publication number: 20030144189
    Abstract: This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject, as well as methods for increasing vascularization in a tissue, particularly in ovarian tissue.
    Type: Application
    Filed: April 9, 2002
    Publication date: July 31, 2003
    Inventors: Joyce Lustbader, Leslie Lobel
  • Expression of properly folded and soluble extracellular domain of a gonadotropin receptor
    Publication number: 20020128190
    Abstract: This invention provides a nucleic acid which encodes a soluble polypeptide which comprises the extracellular domain of a gonadotropin receptor and thioredoxin, wherein the soluble polypeptide is capable of binding to the gonadotropin. This invention also provides the polypeptides encoded by these nucleic acids and methods to produce the polypeptides. This invention also provides methods of preventing or terminating pregnancy, preventing or treating cancer, and decreasing androgen and estrogen production.
    Type: Application
    Filed: March 9, 2001
    Publication date: September 12, 2002
    Inventors: Leslie Lobel, Joyce Lustbader