Patents by Inventor Leslie M Palmer

Leslie M Palmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds
    Patent number: 7422749
    Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.
    Type: Grant
    Filed: January 25, 2007
    Date of Patent: September 9, 2008
    Assignee: Affinium Pharmaceuticals, Inc.
    Inventors: Michael T. Black, Martin K. Burnham, Jason C. Fedon, John E. Hodgson, David J. Knowles, Michael A. Lonetto, Richard O. Nicholas, Leslie M. Palmer, Julie M. Pratt, Raymond W. Reichard, Martin Rosenberg, Christopher M. Traini, Judith Ward, Richard L. Warren
  • Map
    Publication number: 20030235842
    Abstract: The invention provides map polypeptides and polynucleotides encoding map polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing map polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: February 26, 2003
    Publication date: December 25, 2003
    Inventors: Martin K. R. Burnham, Leslie M. Palmer, Christopher M. Traini
  • Fucose kinase
    Patent number: 6511839
    Abstract: The invention provides fucose kinase promoter polynucleotides and methods for producing and using such polynucleotides, as well as their variants, agonists and antagonists, and their uses.
    Type: Grant
    Filed: June 9, 2000
    Date of Patent: January 28, 2003
    Inventors: Pan Fong Chan, Sanjoy Biswas, David J. Holmes, Michael A. Lonetto, Leslie M. Palmer, Stephanie Van Horn, Richard L. Warren, Jr., Magdalena Zalacain
  • Topoisomerase I
    Patent number: 6274139
    Abstract: Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: August 14, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Michael N. Gwynn, Howard Kallendar, Leslie M. Palmer
  • FabF
    Patent number: 6168797
    Abstract: The invention provides fabF polypeptides and polynucleotides encoding fabF polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing fabF polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: August 18, 1999
    Date of Patent: January 2, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, Martin K R Burnham, Jason C Fedon, David J Holmes, Karen A Ingraham, Howard Kallender, John T Lonsdale, Marie J Mazzulla, Karen M O'Dwyer, Leslie M Palmer, Chi Young So, Christopher M Traini, Glenn S Van Aller, Stephanie Van Horn, Magdalena Zalacain
  • Topoisomerase III
    Patent number: 6156310
    Abstract: Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.
    Type: Grant
    Filed: May 12, 1999
    Date of Patent: December 5, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael N. Gwynn, Howard Kallendar, Leslie M. Palmer
  • Method for determining gene essentiality in a pathogen
    Patent number: 6139817
    Abstract: The present invention provides a method for determining pathogen sensitivity to varying levels of reduction of a gene product using an expression vector system having a promoter that is essentially off in vitro and turns on selectively during the infection process in vivo. Genes and gene products identified by this method as essential to growth of infection of a selected pathogen are also provided. In addition, therapeutic compositions designed to target genes identified by this method are provided.
    Type: Grant
    Filed: January 21, 1998
    Date of Patent: October 31, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Leslie M. Palmer, Julie M. Pratt, Martin M. Rosenberg
  • Topoisomerase III
    Patent number: 6025156
    Abstract: Topoisomerase III polypeptides and DNA and RNA encoding such Topoisomerase III polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase III for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase III and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase III nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase III and for detecting the polypeptide in a host.
    Type: Grant
    Filed: October 14, 1997
    Date of Patent: February 15, 2000
    Assignee: Smithkline Beecham Corporation
    Inventors: Michael N. Gwynn, Howard Kallendar, Leslie M. Palmer
  • Topoisomerase I
    Patent number: 6013505
    Abstract: Topoisomerase I polypeptides and DNA and RNA encoding such Topoisomerase I polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such Topoisomerase I for the treatment of infection, particularly bacterial infections. Antagonists against such Topoisomerase I and their use as a therapeutic to treat infections, particularly bacterial infections are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to the presence of Topoisomerase I nucleic acid sequences and the polypeptides in a host. Also disclosed are diagnostic assays for detecting polynucleotides encoding Staphylococcal Topoisomerase I and for detecting the polypeptide in a host.
    Type: Grant
    Filed: October 7, 1997
    Date of Patent: January 11, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Michael N. Gwynn, Howard Kallendar, Leslie M. Palmer