Patents by Inventor Leslie M. Werbel

Leslie M. Werbel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5177075
    Abstract: The invention is selected, novel, and known analogs of isoquinolinones of the formula ##STR1## and pharmaceutically acceptable salts thereof; novel pharmaceutical compositions; and a method for enhancing the lethal effects for tumor cells to treatment having DNA damaging activity such as ionizing radiation or with chemotherapeutic agents.
    Type: Grant
    Filed: September 11, 1991
    Date of Patent: January 5, 1993
    Assignee: Warner-Lambert Company
    Inventors: Mark J. Suto, William R. Turner, Leslie M. Werbel
  • Patent number: 4999444
    Abstract: Novel cyclodiamineplatinum(II) and platinum(IV) complexes which are useful in inhibiting the growth of malignant neoplasms, as well as novel pharmaceutical compositions and methods of use, as well as processes for their manufacture are herein described.
    Type: Grant
    Filed: March 10, 1989
    Date of Patent: March 12, 1991
    Assignee: Warner-Lambert Co.
    Inventors: James D. Hoeschele, Leslie M. Werbel
  • Patent number: 4857530
    Abstract: Novel 6-substituted-4(3H)-quinazolinones are described as well as methods for the preparation and pharmaceutical composition of same, which inhabit the enzyme thymidylate synthase (TS) and are thus useful as anticancer agents.
    Type: Grant
    Filed: November 3, 1987
    Date of Patent: August 15, 1989
    Assignee: Warner-Lambert Company
    Inventors: Ellen M. Berman, Leslie M. Werbel, Dennis J. McNamara
  • Patent number: 4797397
    Abstract: Certain .alpha.-[(2-nitro-1H-imidazol-1-yl)methyl]-aziridinylethanols and the corresponding aziridine-ring opened analogs are useful as radiation sensitizers for X-irradiation therapy of tumors.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: January 10, 1989
    Assignee: Warner-Lambert Company
    Inventors: Mark J. Suto, Leslie M. Werbel
  • Patent number: 4659708
    Abstract: The subject 8-[6-(N-heterocyclic-substituted)hexylamino]-6-methoxy lepidine erivatives have the formula: ##STR1## wherein Z represents methyl or, together with the two contiguous carbon atoms, the benzo moiety of a benzopiperazinyl derivative when Y is --N(R')--, n is an integer from 0 to 2; Y represents --O--, --S--, --S(O)--, --S(O).sub.2 --, and --N(R')--; R' represents hydrogen, alkyl, lower alkyl, R" substituted lower alkyl, cycloalkyl, aryl, sulfonyl, saturated 1,4-diazepinyl, lower alkyl N-cyanocarboximidothioate, or --C(O)R'"; R" represents at least one of hydroxy, alkoxy, aralkoxy, amino, lower alkyl substituted amino, phenyl, halogenated phenyl, or sufonyl; and R'" represents lower alkyl, alkoxy, aralkoxy, amino, lower alkyl substituted amino or aryl substituted amino; and pharmaceutically acceptable salts thereof. These derivatives afford improvement in means for the chemotherapy of leishmaniasis when administered parenterally or orally to infected animals.
    Type: Grant
    Filed: August 20, 1981
    Date of Patent: April 21, 1987
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Leslie M. Werbel, Edgar A. Steck
  • Patent number: 4604390
    Abstract: Substituted 2H-[1]benzopyrano[4,3,2-cd]indazoles, 2H-[1]benzothiopyrano[4,3,2-cd]indazoles, and 2H-[1]benzoselenino[4,3,2-cd]indazoles have demonstrated pharmacological activity against a broad spectrum of Gram-positive and Gram-negative bacteria, yeasts, and fungi, as well as activity against the L1210 and P388 murine leukemia cells lines.Pharmaceutical compositions containing the compounds and methods of employing the compounds in methods of treating bacterial or fungal infections and of inhibiting the growth of neoplasms in mammals are also disclosed.
    Type: Grant
    Filed: May 24, 1985
    Date of Patent: August 5, 1986
    Assignee: Warner-Lambert Company
    Inventors: Edward F. Elslager, Leslie M. Werbel, Daniel F. Ortwine, Donald F. Worth, Howard D. H. Showalter, David B. Capps, Ellen M. Berman, Vlad E. Gregor, Anthony D. Sercel
  • Patent number: 4556654
    Abstract: Substituted anthra[1,9-cd]pyrazol-6(2H-ones have antimicrobial activity. Methods for their preparation, use and pharmaceutical compositions are disclosed.
    Type: Grant
    Filed: June 28, 1983
    Date of Patent: December 3, 1985
    Assignee: Warner-Lambert Company
    Inventors: Howard D. H. Showalter, Judith L. Johnson, Leslie M. Werbel, Edward F. Elslager
  • Patent number: 4532240
    Abstract: Substituted-phenyl derivatives of 5-(1,4-piperazinyl)-2,4-pyrimidinediamine are effective as antibacterial and antitumor agents. Methods of preparing such compounds, pharmaceutical compositions based thereon, and a method of treating bacterial infections in a mammal in need of such treatment are disclosed.
    Type: Grant
    Filed: August 9, 1983
    Date of Patent: July 30, 1985
    Assignee: Warner-Lambert Company
    Inventors: Leslie M. Werbel, Jocelyn H. Hung
  • Patent number: 4515793
    Abstract: A compound of the formula ##STR1## in which A is ##STR2## n is 1, 2 or 3, and R is phenyl optionally substituted with halogen, alkyl, phenyl, cyano, hydroxy, alkoxy, mercapto, sulfinyl, sulfonyl, amino, nitro, trifluoromethyl and/or naphthyl radicals; or a furan, thiophene, pyridine, benzofuran, dibenzothiophene or thianthrene radical,or a pharmacologically acceptable salt thereof, for treating schistosomiasis.
    Type: Grant
    Filed: July 27, 1983
    Date of Patent: May 7, 1985
    Assignee: Edna McConnell Clark Foundation
    Inventors: Leslie M. Werbel, Norman Colbry, William Turner, Donald F. Worth
  • Patent number: 4505925
    Abstract: The title compositions containing N,N-diethyl-5-methyl-2H-12-benzothiopyrano-4,3,2-cd-indazole-2-ethanamine as the free base (I) or pharmaceutically acceptable acid addition salt, and methods for their use are provided. The compositions are useful for treating tumors in warm blooded animals.
    Type: Grant
    Filed: May 20, 1983
    Date of Patent: March 19, 1985
    Assignee: Warner-Lambert Company
    Inventors: Edward F. Elslager, Leslie M. Werbel
  • Patent number: 4291034
    Abstract: 7-Chloro-3-substituted aryl-3,4-dihydro-1,9-(2H,1OH) and 10-hydroxy-acridinedioneimines and their pharmaceutically acceptable salts and a process for preparing them are disclosed and claimed. The compounds are useful in the treatment of protozoan diseases.
    Type: Grant
    Filed: March 20, 1980
    Date of Patent: September 22, 1981
    Assignee: Warner Lambert Company
    Inventor: Leslie M. Werbel
  • Patent number: 4234583
    Abstract: 2-Chloro-4-(4-lower alkyl-1-piperazinyl)benzenemethanol, -oxides and their acid addition salts. These compounds are prepared by oxidizing the corresponding 2-chloro-4-(4-lower alkyl-1-piperazinyl)benzenemethanol. In addition, pharmaceutical compositions comprising said N-oxides and methods for treating schistosomiasis are disclosed.
    Type: Grant
    Filed: November 30, 1978
    Date of Patent: November 18, 1980
    Assignee: Edna McConnell Clark Foundation
    Inventors: Ernest Bueding, Leslie M. Werbel, Donald F. Worth