Abstract: The present invention is directed to the anti-LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3-binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.

Abstract: The present invention relates to Tri-Specific Binding Molecules, which are multi-chain polypeptide molecules that possess three Binding Domains and are thus capable of mediating coordinated binding to three epitopes. The Tri-Specific Binding Molecule is preferably characterized in possessing binding domains that permit it to immunospecifically bind to: (1) an epitope of a first Cancer Antigen, (2) an epitope of a second Cancer Antigen, and (3) an epitope of a molecule that is expressed on the surface of an immune system effector cell, and are thus capable of localizing an immune system effector cell to a cell that expresses a Cancer Antigen, so as to thereby facilitate the killing of such cancer cell.

Abstract: The present invention is directed to binding molecules that possess one or more epitope-binding sites specific for an epitope of CD137 and one or more epitope-binding sites specific for an epitope of a tumor antigen (“TA”) (e.g., a “CD137×TA Binding Molecule”). In one embodiment, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific tetravalent diabodies, that are composed of two, three, four or more than four polypeptide chains and possessing two epitope-binding sites each specific for an epitope of CD137 and two epitope-binding sites each specific for an epitope of a TA. Alternatively, such CD137×TA Binding Molecules will be bispecific molecules, especially bispecific trivalent binding molecules composed of three or more polypeptide chains and possessing one or two epitope-binding sites each specific for an epitope of CD137 and one or two epitope-binding sites each specific for an epitope of a TA.

Abstract: The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that possess at least one epitope-binding site that is immunospecific for an epitope of PD-1 and at least one epitope-binding site that is immunospecific for an epitope of CTLA-4 (i.e., a “PD-1×CTLA-4 bispecific molecule”). The PD-1×CTLA-4 bispecific molecules of the present invention are capable of simultaneously binding to PD-1 and to CTLA-4, particularly as such molecules are arrayed on the surfaces of human cells. The invention is directed to pharmaceutical compositions that contain such PD-1×CTLA-4 bispecific molecules, and to methods involving the use of such bispecific molecules in the treatment of cancer and other diseases and conditions. The present invention also pertains to methods of using such PD-1×CTLA-4 bispecific molecules to stimulate an immune response.

Abstract: A rack apparatus includes a top member and a bottom member. A first extension arm is pivotably attached to the bottom member and a second extension arm is pivotably attached to the bottom member. A first linkage arm is pivotably attached to the top member and slideably attached to the first extension arm, and a second linkage arm is pivotably attached to the top member and slideably attached to the second extension arm. The rack apparatus is displaceable between a stowed position and a use position via linear displacement of the bottom member. When in the stowed position, the first and second extension arms are positioned alongside the top and bottom members, and when in the use position, the first and second extension arms extend away from the bottom member.

Abstract: A method and system are described for tracking a process of provisioning, by a middleware server to a portable device in a mobile payment system, electronic wallet data for authorizing a payment transaction. In an embodiment, a user request for a payment account product is transmitted by the portable device to the middleware server. In response, the middleware server initiates a provisioning process for the requested payment account product, including storing status data indicative of an initiated state of the provisioning process. The middleware server then transmits a digital document to the portable device, including information that must be viewed by the user, and updates the status data indicative of a transmitted state of the digital document. In response to receiving an indication that the digital document has been viewed, the middleware server updates the stored status data indicative of a digital document viewed state.

Abstract: A method and system are described for tracking a process of provisioning, by a middleware server to a portable device in a mobile payment system, electronic wallet data for authorizing a payment transaction. In an embodiment, a user request for a payment account product is transmitted by the portable device to the middleware server. In response, the middleware server initiates a provisioning process for the requested payment account product, including storing status data indicative of an initiated state of the provisioning process. The middleware server then transmits a digital document to the portable device, including information that must be viewed by the user, and updates the status data indicative of a transmitted state of the digital document. In response to receiving an indication that the digital document has been viewed, the middleware server updates the stored status data indicative of a digital document viewed state.

Abstract: A method and system are described for tracking a process of provisioning, by a middleware server to a portable device in a mobile payment system, electronic wallet data for authorizing a payment transaction. In an embodiment, a user request for a payment account product is transmitted by the portable device to the middleware server. In response, the middleware server initiates a provisioning process for the requested payment account product, including storing status data indicative of an initiated state of the provisioning process. The middleware server then transmits a digital document to the portable device, including information that must be viewed by the user, and updates the status data indicative of a transmitted state of the digital document. In response to receiving an indication that the digital document has been viewed, the middleware server updates the stored status data indicative of a digital document viewed state.

Abstract: A method for enabling seamless transitions for a cinema presentation package, wherein the cinema presentation package includes pre-shows, trailers, live events, and main features, the steps include determining the requirements of specific protocols corresponding to the cinema presentation that will affect transitioning between the pre-shows, trailers, live events, and main features. Transition behaviors have to be identified between the pre-shows, trailers, live events, and main features that form the cinema presentation package. Flexibility exists in displaying the cinema presentation package, and yet the pre-shows, trailers, live events, and main features are displayed according to the specific protocols and transition rules associated with the specific protocols.

Abstract: Methods and Systems are provided for routing a call to a landline communication unit or a wireless communication unit based on the availability of the wireless communication unit. A call placed to a landline communication unit is routed to the wireless communication unit if the wireless communication unit is determined available. Otherwise, the call is routed to the landline communication unit.

Abstract: A method for delivering digital cinema concurrently to a retail exhibitor and a remote theater that includes forming a digital cinema right-to-distribute contract between a content owner and a retail exhibitor. In addition, a digital cinema movie rental contract is formed between the retail exhibitor and a remote theater user. Newly released digital cinema content is delivered both to the remote theater and to the retail exhibitor. Display of the newly released digital cinema content occurs at the remote theater as early as the display of the newly released digital cinema content at the retail exhibitor.

Abstract: An independent power bank system and intended use therefor, comprising an electromagnetic field generator and a power bank comprising one or more light bulbs, the light bulbs being filled with a gas capable of being lighted when subjected to a generated electromagnetic field; a system for producing usable voltage by producing a photovoltaic effect, said system being in a juxtaposition relationship to the one or more light bulbs; and a secondary antenna connected at one end to each end of the one or more light bulbs and another end being located near an edge of the generated electromagnetic field. The invention typically may be adapted to have a plurality of power banks arranged in a desired configuration to suit the intended use.

Abstract: An independent power bank system and intended use therefor, comprising an electromagnetic field generator and a power bank comprising one or more light bulbs, the light bulbs being filled with a gas capable of being lighted when subjected to a generated electromagnetic field; a system for producing usable voltage by producing a photovoltaic effect, said system being in a juxtaposition relationship to the one or more light bulbs; and a secondary antenna connected at one end to each end of the one or more light bulbs and another end being located near an edge of the generated electromagnetic field. The invention typically may be adapted to have a plurality of power banks arranged in a desired configuration to suit the intended use.

Abstract: A system that determines a projector's true state in an automatic projection sequence. The system includes a projector in a primary display system, having a lamp for displaying visual information; and a sensor to determine the state of the lamp in the primary display system. Additionally, an interface to a secondary display system is included for sending an operational signal to the secondary display system, wherein the secondary display system operates subject to a predetermined state of the primary display system as determined by the state of the lamp in the primary display system.

Abstract: A method is described for rapidly changing digital content for a digital cinema house. The method includes assigning the digital content to a first server for transmitting to a first projector in a cinema house; and deciding to change an assigned playback location of the digital content to a second projector. Next, actually changing the assigned playback location of the digital content to a second projector; and switching the assigned playback of the digital content directly from the first server to the second projector.

Abstract: A method for enabling seamless transitions for a cinema presentation package, wherein the cinema presentation package includes pre-shows, trailers, live events, and main features, the steps include determining the requirements of specific protocols corresponding to the cinema presentation that will affect transitioning between the pre-shows, trailers, live events, and main features. Transition behaviors have to be identified between the pre-shows, trailers, live events, and main features that form the cinema presentation package. Flexibility exists in displaying the cinema presentation package, and yet the pre-shows, trailers, live events, and main features are displayed according to the specific protocols and transition rules associated with the specific protocols.

Abstract: An adjustable guide rail system for transporting products is disclosed. The system comprises a pair of parallel conveyor side panels having upper surfaces in a common plane. A conveyor chain is formed as a plurality of rectangular slats having lower surfaces slidable along the upper surfaces of the conveyor side panel. The upper surfaces of the slats function for the receipt of products to be conveyed. A plurality of spacers/adjuster slide blocks are located at spaced apart locations between the conveyor side panels. The spacers/adjuster slide blocks have central apertures axially aligned therein. A plurality of pairs of parallel oriented adjuster slides are mounted for axial movement above and below the apertures of the spacer/adjuster slide blocks. The adjuster slide of each pair having gear teeth in linear alignment, thereby constituting racks.

Abstract: A system for filling bottles with pills including a drive wheel formed with an upper generally circular plate and a vertically spaced lower generally circular plate with concentric peripheries and axially aligned central apertures extending therethrough supportable on a drive shaft for rotation therewith. The plates are formed with a plurality of symmetrically located recesses on the peripheries of the plates for receiving bottles therein. A depth spacer is positioned within each recess and is radially movable toward and away from the axis of rotation and the peripheries of the plates. A pair of width plates are positioned on opposite sides of each recess to vary the width of each recess. The depth spacers and width plates allow the recesses to accommodate various sizes of bottles so that the openings in the bottles will be properly positioned at all times for use in automated pill dispensing systems.