Patents by Inventor Leslie Morton Werbel

Leslie Morton Werbel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diaminopyrimidines and combination therapies effective for treatment of P-glycoprotein positive cancers
    Publication number: 20040006042
    Abstract: The present invention provides compounds of Formula II: 1
    Type: Application
    Filed: May 28, 2003
    Publication date: January 8, 2004
    Inventors: David Allen Berry, Ellen Myra Dobrusin, Judith Lynne Johnson-Philipsen, Wayne Daniel Klohs, Dennis Joseph McNamara, Leslie Morton Werbel
  • Quinazolines as inhibitors of endothelin converting enzyme
    Patent number: 5773444
    Abstract: Novel quinazoline inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin and in controlling hypertension, myocardial infarction and ischemia, metabolic, endocrinological, and neurological disorders, congestive heart failure, endotoxic and hemorrhagic shock, septic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute and chronic renal failure, cyclosporin-A induced nephrotoxicity, angina, gastric mucosal damage, ischemic bowel disease, cancer, pulmonary hypertension, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, cerebral ischemia and vasospasm, and diabetes.
    Type: Grant
    Filed: April 14, 1997
    Date of Patent: June 30, 1998
    Assignee: Warner-Lambert Company
    Inventors: Kyunghye Ahn, Xue-Min Cheng, Annette Marian Doherty, Edward Faith Elslager, Brian Kornberg, Chitase Lee, Daniele Leonard, Sham Nikam, Leslie Morton Werbel
  • Quinazolines as inhibitors of endothelin converting enzyme
    Patent number: 5658902
    Abstract: Novel quinazoline inhibitors of endothelin converting enzyme are described, as well as methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin and in controlling hypertension, myocardial infarction and ischemia, metabolic, endocrinological, and neurological disorders, congestive heart failure, endotoxic and hemorrhagic shock, septic shock, subarachnoid hemorrhage, arrhythmias, asthma, acute and chronic renal failure, cyclosporin-A induced nephrotoxicity, angina, gastric mucosal damage, ischemic bowel disease, cancer, pulmonary hypertension, preeclampsia, atherosclerotic disorders including Raynaud's disease and restenosis, cerebral ischemia and vasospasm, and diabetes.
    Type: Grant
    Filed: December 22, 1994
    Date of Patent: August 19, 1997
    Assignee: Warner-Lambert Company
    Inventors: Kyunghye Ahn, Xue-Min Cheng, Annette Marian Doherty, Edward Faith Elslager, Brian Kornberg, Chitase Lee, Daniele Leonard, Sham Nikam, Leslie Morton Werbel