Patents by Inventor Leslie Muller
Leslie Muller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11754571Abstract: Methods for peptide and/or protein quantification by mass spectrometry using labeled peptides, wherein multiple labels lead to distinct fragments for the labeled peptides and their unlabeled variant, thus facilitating data analysis and enhancing the potential for quantification. Methods for selecting the label and label position are further given, as well as sets of labeled peptides resulting from or for use in the above-mentioned methods. The methods and substances are especially useful for data-independent or multiplexed parallel reaction monitoring proteomics applications involving peptide quantification.Type: GrantFiled: February 25, 2022Date of Patent: September 12, 2023Assignee: BiognoSYS AGInventors: Lukas Reiter, Susanne Leslie Müller
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Publication number: 20220178942Abstract: Methods for peptide and/or protein quantification by mass spectrometry using labeled peptides, wherein multiple labels lead to distinct fragments for the labeled peptides and their unlabeled variant, thus facilitating data analysis and enhancing the potential for quantification. Methods for selecting the label and label position are further given, as well as sets of labeled peptides resulting from or for use in the above-mentioned methods. The methods and substances are especially useful for data-independent or multiplexed parallel reaction monitoring proteomics applications involving peptide quantification.Type: ApplicationFiled: February 25, 2022Publication date: June 9, 2022Applicant: BiognoSYS AGInventors: Lukas REITER, Susanne Leslie MÜLLER
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Patent number: 11293928Abstract: Methods for peptide and/or protein quantification by mass spectrometry using labeled peptides, wherein multiple labels lead to distinct fragments for the labeled peptides and their unlabeled variant, thus facilitating data analysis and enhancing the potential for quantification. Methods for selecting the label and label position are further given, as well as sets of labeled peptides resulting from or for use in the above-mentioned methods. The methods and substances are especially useful for data-independent or multiplexed parallel reaction monitoring proteomics applications involving peptide quantification.Type: GrantFiled: August 17, 2017Date of Patent: April 5, 2022Assignee: BiognoSYS AGInventors: Lukas Reiter, Susanne Leslie Müller
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Patent number: 10430430Abstract: A computer method, system and apparatus control access to secured data in a plurality of databases. A repository is coupled to the databases and has a security runtime subsystem. The repository intercepts a user query of a subject database in the plurality. The security runtime subsystem determines from the intercepted query a user and corresponding user role. Based on user role, the security runtime subsystem automatically modifies the user query to filter out secure data for which the identified user is unauthorized to access but are part of the user query.Type: GrantFiled: March 11, 2011Date of Patent: October 1, 2019Assignee: VMware, Inc.Inventors: Leslie Muller, Michael Morris Wasser, Alberto Arias Maestro
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Publication number: 20190187152Abstract: Methods for peptide and/or protein quantification by mass spectrometry using labeled peptides, wherein multiple labels lead to distinct fragments for the labeled peptides and their unlabeled variant, thus facilitating data analysis and enhancing the potential for quantification. Methods for selecting the label and label position are further given, as well as sets of labeled peptides resulting from or for use in the above-mentioned methods. The methods and substances are especially useful for data-independent or multiplexed parallel reaction monitoring proteomics applications involving peptide quantification.Type: ApplicationFiled: August 17, 2017Publication date: June 20, 2019Applicant: BiognoSYS AGInventors: Lukas REITER, Susanne Leslie MÜLLER
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Patent number: 9851989Abstract: Methods and apparatus to manage virtual machines are described. An example method includes presenting a list of available basic blueprints, storing a multi-machine blueprint referencing a first basic blueprint for a first virtual machine from the list and a second basic blueprint for a second virtual machine from the list, and in response to a request to provision the multi-machine blueprint, the request including an identification of a first number of instances to be provisioned for the first virtual machine and a second number of instances to be provisioned for the second virtual machine, provisioning the first number of instances of the first virtual machine and the second number of instances of the second virtual machine.Type: GrantFiled: December 12, 2013Date of Patent: December 26, 2017Assignee: VMware, Inc.Inventors: Leslie Muller, Valentina Reutova, Ken Pespisa, Mike Barron, Murat Bayan, Frederic Torres, Dave Zolotusky, Derek Chasse, Sudershan Bhandari
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Patent number: 9852206Abstract: In a method of controlling access to secured data, a repository operatively coupled to one or more databases storing secure data is employed to intercept a user query of one database of the one or more databases. A user who generated the user query and a user role assigned to the user is automatically determined from the intercepted query. The intercepted query is parsed. Security information of the identified objects is looked up in a metamodel stored in the one or more databases. Based on the determined user role and the identified objects to be filtered out of the user query, an expression tree to filter out secure data is automatically built and the user query is modified by appending the expression tree to the user query. The modified query is applied to the one database.Type: GrantFiled: May 8, 2015Date of Patent: December 26, 2017Assignee: VMware, Inc.Inventors: Leslie Muller, Michael Morris Wasser, Alberto Arias Maestro
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Patent number: 9652267Abstract: Managing virtual and real machines through a provisioning system. The provisioning system allows a user to create and manage machines through a “self-service” approach. The provisioning system interacts with one or more agents that manage the lifecycle of a machine. The system may provide templates that enable a user to readily create a virtual machine. The system may also include interfaces for administrators to manage virtual and real machine resources.Type: GrantFiled: September 2, 2014Date of Patent: May 16, 2017Assignee: VMware, Inc.Inventor: Leslie Muller
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Patent number: 9529613Abstract: Methods and apparatus to reclaim resources in virtual computing environments are described. An example method includes determining, with a processor, if a characteristic of a virtual machine meets a threshold indicating that the virtual machine is inactive, in response to determining that the characteristic meets the threshold, determining, with the processor, if a notification period has expired, and if the notification period has expired, de-provisioning, with the processor, the virtual machine to return computing resources assigned to the virtual machine to a cloud.Type: GrantFiled: December 12, 2013Date of Patent: December 27, 2016Assignee: VMware, Inc.Inventors: Leslie Muller, Valentina Reutova, Ken Pespisa, Mike Barron, Murat Bayan, Frederic Torres, Dave Zolotusky, Derek Chasse, Sudershan Bhandari
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Patent number: 9384361Abstract: A distributed event system for a relational database is disclosed. An event data model operatively describes a target database. For a subject entity in the target database, the event data model declares and defines triggering events and respective corresponding operations. An event engine monitors database queries and events involving the subject entity and determines from the event data model corresponding operations. Execution of the determined corresponding operations is distributed to network-based agents. Agents may be filtered based on skills and/or credentials injected at runtime. Code binaries of the operations are downloaded to the agents for execution.Type: GrantFiled: March 11, 2011Date of Patent: July 5, 2016Assignee: VMware, Inc.Inventors: Leslie Muller, Michael Morris Wasser, Alberto Arias Maestro
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Patent number: 9195707Abstract: A distributed event system for a relational database is disclosed. An event data model operatively describes a target database. For a subject entity in the target database, the event data model declares and defines triggering events and respective corresponding operations. An event engine monitors database queries and events involving the subject entity and determines from the event data model corresponding operations. Execution of the determined corresponding operations is distributed to network-based agents. Agents may be filtered based on skills and/or credentials injected at runtime. Code binaries of the operations are downloaded to the agents for execution.Type: GrantFiled: March 11, 2011Date of Patent: November 24, 2015Assignee: VMware, Inc.Inventors: Leslie Muller, Michael Morris Wasser, Alberto Arias Maestro
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Publication number: 20150317486Abstract: In a method of controlling access to secured data, a repository operatively coupled to one or more databases storing secure data is employed to intercept a user query of one database of the one or more databases. A user who generated the user query and a user role assigned to the user is automatically determined from the intercepted query. The intercepted query is parsed. Security information of the identified objects is looked up in a metamodel stored in the one or more databases. Based on the determined user role and the identified objects to be filtered out of the user query, an expression tree to filter out secure data is automatically built and the user query is modified by appending the expression tree to the user query. The modified query is applied to the one database.Type: ApplicationFiled: May 8, 2015Publication date: November 5, 2015Inventors: Leslie MULLER, Michael Morris WASSER, Alberto Arias MAESTRO
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Patent number: 9058353Abstract: A computer method, system and apparatus control access to secured data in a plurality of databases. A repository is coupled to the databases and has a security runtime subsystem. The repository intercepts a user query of a subject database in the plurality. The security runtime subsystem determines from the intercepted query a user and corresponding user role. Based on user role, the security runtime subsystem automatically modifies the user query to filter out secure data for which the identified user is unauthorized to access but are part of the user query.Type: GrantFiled: March 11, 2011Date of Patent: June 16, 2015Assignee: VMware, Inc.Inventors: Leslie Muller, Michael Morris Wasser, Alberto Arias Maestro
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Publication number: 20150077697Abstract: Various embodiments comprise eyewear that includes a frame that is adapted to support a computing device having at least one sensor. In a particular embodiment, the eyewear defines an opening or cutaway in its frame or one or more of its lenses to allow an infrared sensor, or other sensor, associated with the computing device to monitor the movement of a user's face (e.g. one or more of the user's eyes) through the opening or cutaway. This may, for example, allow the sensor to be used to receive instructions from a user via pre-defined movements of a user's face. The sensor may also be used to detect when the user is wearing the eyewear.Type: ApplicationFiled: September 18, 2014Publication date: March 19, 2015Inventors: Claudio Gottardi, Leslie Muller
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Publication number: 20150007194Abstract: Managing virtual and real machines through a provisioning system. The provisioning system allows a user to create and manage machines through a “self-service” approach. The provisioning system interacts with one or more agents that manage the lifecycle of a machine. The system may provide templates that enable a user to readily create a virtual machine. The system may also include interfaces for administrators to manage virtual and real machine resources.Type: ApplicationFiled: September 2, 2014Publication date: January 1, 2015Inventor: Leslie Muller
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Publication number: 20140368787Abstract: Eyewear in various embodiments comprises a frame configured to support one or more lenses where the frame has a first end, a second end and a top surface extending between the first and second ends. A first temple portion extends rearward from the frame adjacent the frame first end and has a first earpiece extending from the first temple portion. A second temple portion comprises (1) a computing device support arm extending parallel to the first temple portion adjacent the frame second end and (2) a computing device support arm mount coupled at least partially along at least a portion of the top surface adjacent the frame second end and configured to support a computing device either releasably coupled, or permanently attached, to the computing device support arm so a display of the computing device is positioned substantially in the upper portion of one of the one or more lenses.Type: ApplicationFiled: June 16, 2014Publication date: December 18, 2014Inventors: Claudio Gottardi, Leslie Muller, Lucy Wang, Jane Tsoi, Massimo Baldissarutti
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Patent number: 8826289Abstract: Managing virtual and real machines through a provisioning system. The provisioning system allows a user to create and manage machines through a “self-service” approach. The provisioning system interacts with one or more agents that manage the lifecycle of a machine. The system may provide templates that enable a user to readily create a virtual machine. The system may also include interfaces for administrators to manage virtual and real machine resources.Type: GrantFiled: March 26, 2012Date of Patent: September 2, 2014Assignee: VMware, Inc.Inventor: Leslie Muller
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Publication number: 20140181817Abstract: Methods and apparatus to manage execution of virtual machine workflows are described. An example method includes determining that an execution manager that has requested a first workflow for execution is tagged with a skill, selecting, from a queue, a virtual machine workflow that is tagged with the skill and that matches the requested first workflow; and transmitting the virtual machine workflow to the execution manager for execution.Type: ApplicationFiled: December 12, 2013Publication date: June 26, 2014Inventors: Leslie Muller, Valentina Reutova, Ken Pespisa, Mike Barron, Murat Bayan, Frederic Torres, Dave Zolotusky, Derek Chasse, Sudershan Bhandari
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Publication number: 20140181816Abstract: Methods and apparatus to manage virtual machines are described. An example method includes presenting a list of available basic blueprints, storing a multi-machine blueprint referencing a first basic blueprint for a first virtual machine from the list and a second basic blueprint for a second virtual machine from the list, and in response to a request to provision the multi-machine blueprint, the request including an identification of a first number of instances to be provisioned for the first virtual machine and a second number of instances to be provisioned for the second virtual machine, provisioning the first number of instances of the first virtual machine and the second number of instances of the second virtual machine.Type: ApplicationFiled: December 12, 2013Publication date: June 26, 2014Inventors: Leslie Muller, Valentina Reutova, Ken Pespisa, Mike Barron, Murat Bayan, Frederic Torres, Dave Zolotusky, Derek Chasse, Sudershan Bhandari
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Publication number: 20140165060Abstract: Methods and apparatus to reclaim resources in virtual computing environments are described. An example method includes determining, with a processor, if a characteristic of a virtual machine meets a threshold indicating that the virtual machine is inactive, in response to determining that the characteristic meets the threshold, determining, with the processor, if a notification period has expired, and if the notification period has expired, de-provisioning, with the processor, the virtual machine to return computing resources assigned to the virtual machine to a cloud.Type: ApplicationFiled: December 12, 2013Publication date: June 12, 2014Inventors: Leslie Muller, Valentina Reutova, Ken Pespisa, Mike Barron, Murat Bayan, Frederic Torres, Dave Zolotusky, Derek Chasse, Sudershan Bhandari