Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Abstract: Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Abstract: The invention provides map polypeptides and polynucleotides encoding map polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing map polypeptides to screen for antibacterial compounds.

Abstract: This invention relates to newly identified Staphylococcal polynucleotides, polypeptides encoded by such polynucleotides, the uses of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides and recombinant host cells transformed with the polynucleotides. This invention also relates to inhibiting the biosynthesis or action of such polynucleotides or polypeptides and to the use of such inhibitors in therapy.

Abstract: Compounds of this invention are non-peptide, reversible inhibitors of bacterial methionine aminopeptidases, useful in treating bacterial infections.

Abstract: Tap grinding apparatus is provided consisting firstly of a support or cradle mountable in a grinding machine in relation to a thread grinding wheel of the latter for relative traverse of said support and grinding wheel, the support having headstock and tailstock centers for rotatably receiving a tap workpiece whereby the latter is mounted in relation to a said grinding wheel, at least one of said centers being operable for axial retraction relative to the other for obtaining release and discharge of a ground tap workpiece from between the centers. Secondly automatic loading means is provided consisting of a magazine for receiving uniformly arranged tap workpieces to be ground for sliding feed movement there-along to a lifter member, a transfer holder being provided having a spring latch for receiving and holding a tap workpiece raised therein by the lifter member.

Abstract: Apparatus for screw thread tap grinding is provided in which the tap workpiece is oscillated laterally relative to the thread grinding wheel in order to impart relief to the ground thread form of the tap workpiece. The apparatus consists of base structure mountable in a grinding machine for relative traverse of the base structure and grinding wheel and a cradle having a headstock and tailstock for receiving a tap to be ground rotatably mounted therein between centers and parallel with the axis of the grinding wheel, the cradle being pivotally mounted on the base structure for said lateral oscillation and is operated by a gear driven single lobe cam co-operating with a follower on the cradle for effecting the lateral oscillation of the cradle and tap workpiece relative to the grinding wheel. A headstock work center spindle is driven from the grinding machine by a floating center coupling in order to permit the oscillation of the cradle.