Abstract: The disclosure features macrocyclic compounds, and pharmaceutical compositions and protein complexes thereof, capable of inhibiting Ras proteins, and their uses in the treatment of cancers.

Abstract: A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4+) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

Abstract: A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4+) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

Abstract: A vacuum interrupter including a nominally cylindrical insulator having a first insulator portion and a second insulator portion defining a gap therebetween and a nominally cylindrical vapor shield having a first ring of a plurality of spaced apart bobbles and a second ring of a plurality of spaced apart bobbles. A gap ring including a series of spaced apart cut-out notches facing the vapor shield is positioned within the gap. The plurality of bobbles in the first and second ring of bobbles are configured so that the bobbles in the second ring pass through the cut-out notches in the gap ring and the bobbles in the first ring rest on the gap ring.

Abstract: One example method for predictive clinical planning and design includes instantiating a plurality of data objects, each data object of the plurality of data objects comprising clinical trial information; displaying a graphical user interface on one or more display screens, the graphical user interface providing a graphical representation of at least a portion of a clinical trial and comprising a plurality of graphical nodes; receiving a selection of the second graphical node; receiving, via an editor associated with the second graphical node, a modification of the second data object; propagating an indication of the modification to the first data object, the propagation modifying a clinical trial data item of the first data object; and displaying, within the first graphical node, the modified clinical trial data item of the first data object.

Abstract: A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4+) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

Abstract: A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4?) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

Abstract: A medical imaging system including a microwave antenna array having a transmitting antenna and a plurality of receiving antennae, wherein the transmitting antenna is configured to transmit microwave signals so as to illuminate a body part of a patient and the receiving antennae are configured to receive the microwave signals following scattering within the body part; a processor configured to process the scattered microwave signals and generate an output indicative of the internal structure of the body part to identify a region of interest within the body part; and a biopsy device comprising a biopsy needle movable relative to the microwave antenna array; wherein the receiving antennae are further configured to receive microwave signals scattered or emitted by the biopsy needle and the processor is further configured to monitor a position of the biopsy needle and to guide the biopsy needle to the identified region of interest within the body part.

Abstract: A system with an analyzer device in fluid communication with a sample of a bodily fluid is configured to chemically or electrochemically convert at least a portion of ammonium (NH4+) contained within the bodily fluid into ammonia (NH3) and dispel the converted ammonia (NH3) into a gas sensing chamber. An ammonia (NH3) sensor located within the gas sensing chamber in conjunction with a processor can quantify an amount of ammonia (NH3) present in the gas sensing chamber in relation to the total ammonia of the bodily fluid.

Abstract: One example method for predictive clinical planning and design includes instantiating a plurality of data objects, each data object of the plurality of data objects comprising clinical trial information; displaying a graphical user interface on one or more display screens, the graphical user interface providing a graphical representation of at least a portion of a clinical trial and comprising a plurality of graphical nodes; receiving a selection of the second graphical node; receiving, via an editor associated with the second graphical node, a modification of the second data object; propagating an indication of the modification to the first data object, the propagation modifying a clinical trial data item of the first data object; and displaying, within the first graphical node, the modified clinical trial data item of the first data object.

Abstract: One example method for predictive clinical planning and design includes instantiating a plurality of data objects, each data object of the plurality of data objects comprising clinical trial information; displaying a graphical user interface on one or more display screens, the graphical user interface providing a graphical representation of at least a portion of a clinical trial and comprising a plurality of graphical nodes; receiving a selection of the second graphical node; receiving, via an editor associated with the second graphical node, a modification of the second data object; propagating an indication of the modification to the first data object, the propagation modifying a clinical trial data item of the first data object; and displaying, within the first graphical node, the modified clinical trial data item of the first data object.

Abstract: A sleeve anchor for a support and a seating system using the sleeve anchor are disclosed. The sleeve anchor comprises at least one sheet of fabric sewn into a cylinder with an open end and a closed end, at least one strip of fabric extending from the at least one sheet of fabric adapted to provide support to an object. The sleeve anchor is adapted to fit over an end of a support structure.

Abstract: A vacuum switching device may have at least one cup-shaped contact closed by a disc of contact material and a conical mechanical support, which acts to prevent the contact disc from becoming concave. The cup-shaped contact may include a plurality of slots in the sidewalk that extend into the base of the cup, the slots oriented to produce an axial magnetic field when current flows through the contacts. The support may be made of a metal that is a poor conductor of electricity. The narrow end of the cone may be capped by a circular ring or disc, and the wide end may be formed with a flange. The flange may be circular and may be sized and formed to locate the cone centrally in the base of the contact cup. The cone may have apertures to facilitate the evacuation of gas inside the cone.

Abstract: A medical imaging system and method is described. The system comprises: a microwave antenna array comprising a transmitting antenna and a plurality of receiving antennae, wherein the transmitting antenna is configured to transmit microwave signals so as to illuminate a body part of a patient and the receiving antennae are configured to receive the microwave signals following scattering within the body part; a marker configured to be applied to the surface of the skin of the body part and to scatter the microwave signals; a processor configured to process the scattered microwave signals and generate an image of the internal structure of the body part and the marker so as to identify a region of interest within the body part relative to the position of the marker.

Abstract: A vacuum switching device may have at least one cup-shaped contact closed by a disc of contact material and a conical mechanical support, which acts to prevent the contact disc from becoming concave. The cup-shaped contact may include a plurality of slots in the sidewalk that extend into the base of the cup, the slots oriented to produce an axial magnetic field when current flows through the contacts. The support may be made of a metal that is a poor conductor of electricity. The narrow end of the cone may be capped by a circular ring or disc, and the wide end may be formed with a flange. The flange may be circular and may be sized and formed to locate the cone centrally in the base of the contact cup. The cone may have apertures to facilitate the evacuation of gas inside the cone.

Abstract: An alternating current vacuum switching device for switching an electrical circuit under load and no load conditions, and optionally short-circuit conditions is disclosed. The switching device comprises: a vacuum evacuated housing; first and second electrodes within the housing; and an actuator for moving the first electrode relative to the second electrode to mechanically engage and disengage the electrodes to perform a switching function, wherein the first electrode is wholly located within the vacuum evacuated housing such that movement of the switching function occurs solely within the housing. By having movement of the switching function solely within the housing, the reliability of the vacuum switching device is improved.

Abstract: An alternating current vacuum switching device for switching an electrical circuit under load and no load conditions, and optionally short-circuit conditions is disclosed. The switching device comprises: a vacuum evacuated housing; first and second electrodes within the housing; and an actuator for moving the first electrode relative to the second electrode to mechanically engage and disengage the electrodes to perform a switching function, wherein the first electrode is wholly located within the vacuum evacuated housing such that movement of the switching function occurs solely within the housing. By having movement of the switching function solely within the housing, the reliability of the vacuum switching device is improved.

Abstract: A medical imaging system and method is described. The system comprises: a microwave antenna array comprising a transmitting antenna and a plurality of receiving antennae, wherein the transmitting antenna is configured to transmit microwave signals so as to illuminate a body part of a patient and the receiving antennae are configured to receive the microwave signals following scattering within the body part; a marker configured to be applied to the surface of the skin of the body part and to scatter the microwave signals; a processor configured to process the scattered microwave signals and generate an image of the internal structure of the body part and the marker so as to identify a region of interest within the body part relative to the position of the marker.

Abstract: A medical imaging system including a microwave antenna array having a transmitting antenna and a plurality of receiving antennae, wherein the transmitting antenna is configured to transmit microwave signals so as to illuminate a body part of a patient and the receiving antennae are configured to receive the microwave signals following scattering within the body part; a processor configured to process the scattered microwave signals and generate an output indicative of the internal structure of the body part to identify a region of interest within the body part; and a biopsy device comprising a biopsy needle movable relative to the microwave antenna array; wherein the receiving antennae are further configured to receive microwave signals scattered or emitted by the biopsy needle and the processor is further configured to monitor a position of the biopsy needle and to guide the biopsy needle to the identified region of interest within the body part.

Abstract: The present invention provides an apparatus and method for controlling the height of a clip of sheet material that is independent from the other steps of the manufacturing, converting and packaging operations. The invention comprises introducing positive pressure air flow after the clip has been at least partially inserted into a carton. Positive pressure air flow is provided in a direction substantially parallel to the longitudinal axis of the clip and transverse to the cut end of the sheet causing the clip to increase in height. The degree of increase may be controlled by controlling the positive air pressure, while the carton acts as a restraint for the clip.