Abstract: The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

Abstract: The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

Abstract: The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

Abstract: The present invention provides for antimicrobial medical articles prepared by a method comprising treating a surface of the medical article with a solution consisting essentially of one or more solvents and a mixture of chlorhexidine free base and a water-soluble chlorhexidine salt, at a weight/weight ratio of between about 1:1 to about 1:5, wherein the combined concentration of chlorhexidine free base and a water-soluble salt of chlorhexidine is about 2% (w/v) or greater. In alternative embodiments, the antimicrobial medical articles may be treated with a similar solution in which the concentrations of chlorhexidine free base and a water-soluble salt of chlorhexidine are each about 0.20 percent (w/v). Other embodiments include those in which the solvent comprises methanol, or the treatment solution further comprises a silver salt, one or more organic acids, an anti-inflammatory agent, and a hydrogel.

Abstract: The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

Abstract: The present invention provides for antimicrobial medical articles prepared by a method comprising treating a surface of the medical article with a solution consisting essentially of one or more solvents and a mixture of chlorhexidine free base and a water-soluble chlorhexidine salt, at a weight/weight ratio of between about 1:1 to about 1:5, wherein the combined concentration of chlorhexidine free base and a water-soluble salt of chlorhexidine is about 2% (w/v) or greater. In alternative embodiments, the antimicrobial medical articles may be treated with a similar solution in which the concentrations of chlorhexidine free base and a water-soluble salt of chlorhexidine are each about 0.20 percent (w/v). Other embodiments include those in which the solvent comprises methanol, or the treatment solution further comprises a silver salt, one or more organic acids, an anti-inflammatory agent, and a hydrogel.

Abstract: The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.

Abstract: The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.

Abstract: The present invention relates to compositions comprising a combination of one or more antiseptic and an antibiotic. It is based, at least in part, on the discovery that such combinations tend to deter the formation of antibiotic-resistant organisms. In preferred, nonlimiting embodiments of the invention, the antibiotic is minocycline and the antiseptic is a chlorhexidine compound, triclosan, or benzalkonium chloride, and in particular embodiments, a silver salt or a bismuth salt is added. Examples of specific, nonlimiting embodiments of the invention include combinations of (i) minocycline, triclosan, and a bismuth salt; (ii) minocycline, a chlorhexidine compound, and a bismuth salt; and (iii) minocycline, benzalkonium chloride, and a bismuth salt. The present invention further provides for articles, such as, but not limited to, medical articles, which have been treated with or which otherwise comprise a combination of antiseptic and antibiotic.

Abstract: The present disclosure invention relates to medical devices treated with a solution comprising one or more solvents and a combination of chlorhexidine free base and a water-soluble chlorhexidine salt in a weight/weight ratio of between about 1:1 to about 1:5, preferably about 1:1.

Abstract: The present invention relates to polymeric medical articles comprising the anti-infective agents chlorhexidine and triclosan. It is based, at least in part, on the discovery that the synergistic relationship between these compounds permits the use of relatively low levels of both agents, and on the discovery that effective antimicrobial activity may be achieved when these compounds are comprised in either hydrophilic or hydrophobic polymers. It is also based on the discovery that chlorhexidine free base and triclosan, used together, are incorporated into polymeric medical articles more efficiently. Medical articles prepared according to the invention offer the advantage of preventing or inhibiting infection while avoiding undesirably high release of anti-infective agent, for example into the bloodstream of a subject.

Abstract: The present invention relates to zinc gluconate gel-containing topical compositions which have an anti-irritant effect on the skin. In particular embodiments, the gel matrix may further comprise chlorhexidine gluconate, wherein the zinc gluconate gel diminishes the irritant and/or allergenic effect of the chlorhexidine gluconate.

Abstract: The present invention relates to zinc gluconate gel-containing topical compositions which have an anti-irritant effect on the skin. In particular embodiments, the gel matrix may further comprise chlorhexidine gluconate, wherein the zinc gluconate gel diminishes the irritant and/or allergenic effect of the chlorhexidine gluconate.

Abstract: A composition of matter containing zinc gluconate gel as an irritant-inactivating agent, and a substance which substantially prevents the irritant-inactivating agent from binding to the surface, wherein the irritant-inactivating agent in the composition is present in an amount effective to inactivate irritants in fluids which contact the composition, is described. Surgical instruments and physical barriers with the aforementioned composition applied thereto are also described. A method of inactivating irritants in a fluid contacting skin comprising applying the aforementioned composition to the skin is also disclosed. A method of inactivating irritants in a fluid contacting skin covered with a physical barrier comprising applying the aforementioned composition to the skin is also disclosed.

Abstract: A method of preparing an infection-resistant medical device comprising one or more matrix-forming polymers selected from the group consisting of biomedical polyurethane, biomedical silicones and biodegradable polymers, and antimicrobial agents, especially a synergistic combination of a silver salt and chlorhexidine (or its salts); also disclosed are medical devices having the synergistic composition therein or compositions thereon.

Abstract: A method of preparing an infection-resistant medical device comprising one or more matrix-forming polymers selected from the group consisting of biomedical polyurethane, biomedical silicones and biodegradable polymers, and antimicrobial agents, especially a synergistic combination of a silver salt and chlorhexidine (or its salts); also disclosed are medical devices having the synergistic composition therein or compositions thereon.