Patents by Inventor Lester L. Maravetz
Lester L. Maravetz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8338618Abstract: Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.Type: GrantFiled: November 11, 2011Date of Patent: December 25, 2012Assignee: Reata Pharmaceuticals, Inc.Inventors: Xin Jiang, Jack Greiner, Lester L. Maravetz, Stephen S. Szucs, Melean Visnick
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Publication number: 20120238767Abstract: Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.Type: ApplicationFiled: November 11, 2011Publication date: September 20, 2012Inventors: Xin Jiang, Jack Greiner, Lester L. Maravetz, Stephen S. Szucs, Melean Visnick
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Patent number: 8071632Abstract: Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.Type: GrantFiled: April 20, 2009Date of Patent: December 6, 2011Assignee: Reata Pharmaceuticals, Inc.Inventors: Xin Jiang, Jack Greiner, Lester L. Maravetz, Stephen S. Szucs, Melean Visnick
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Patent number: 7842832Abstract: ?-Amino-?-Cyanoacrylates of formula I where the variables have the following meanings: R1 is n-alkyl, n-alkenyl or alkoxyalkyl; R2,R3 are alkyl, which may be partially or fully halogenated and/or may carry a substituent from the group consisting of cyano, alkoxy, haloalkoxy, alkylthio, haloalkylthio, C1-C6-alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl and haloalkylsulfonyl, are alkenyl or alkynyl; or R2 and R3 together with the carbon atom to which they are attached form a cycloalkyl ring in which one or two nonadjacent CH2 groups may be replaced by oxygen or sulfur, and where the cycloalkyl ring may be substituted by halogen or alkyl; R4 is hydrogen, halogen, cyano or alkyl, where the substituents R2, R3 and R4 or two of the radicals R2, R3 and R4 are not simultaneously methyl, and their agriculturally useful salts, processes and intermediates for their preparation; and the use of these compounds or of compositions comprising these compounds for controlling undesirable plants are described.Type: GrantFiled: December 17, 2002Date of Patent: November 30, 2010Assignee: BASF SEInventors: Albert C. Everson, Daniel J. Coughlin, Michael A. Guaciaro, Linda B. Fleming, Lester L. Maravetz, John L. Huppatz
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Publication number: 20100048911Abstract: Disclosed herein are novel oleanolic acid derivatives. Methods of preparing these compounds are also disclosed. The oleanolic acid derivatives of this invention may be used for the treatment and prevention of many diseases, including cancer, neurological disorders, inflammation, and pathologies involving oxidative stress.Type: ApplicationFiled: April 20, 2009Publication date: February 25, 2010Inventors: Xin Jiang, Jack Greiner, Lester L. Maravetz, Stephen S. Szucs, Melean Visnick
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Patent number: 6352958Abstract: Novel herbicidal compounds, compositions containing them, and methods for their use in controlling weeds are disclosed. The novel herbicidal compounds are represented by formula I: where J is a 1-substituted-6-trifluoromethyl-2,4-pyrimidinedione-3-yl, a 1-substituted-6-trifluoromethyl-1,3,5-triazine-2,4-dion-1-yl, a 3,4,5,6-tetrahydrophthalimid-1-yl, a 4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-on-1-yl, a 5,6,7,8-tetrahydro-1H,3H-[1,3,4]thiadiazolo[3,5-a]pyridazineimin-1-yl, or a 1,6,8-triazabicyclo[4.3.0]-nonane-7,9-dion-8-yl ring attached at the 7 position of a benzofuran, benzoxazole, indole, 2,3-dihydrobenzimidazole or benzimidazole, and X is selected from hydrogen, halogen, cyano, nitro, and amino. Preferred R groups are optionally substituted alkyl groups.Type: GrantFiled: April 12, 2000Date of Patent: March 5, 2002Assignee: FMC CorporationInventors: Scott D. Crawford, Lester L. Maravetz, George Theodoridis, Benjamin Dugan
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Patent number: 6080702Abstract: Disclosed are herbicidal heterocyclic benzisoxazoles and benzisoxazolidinones of formula (I): ##STR1## wherein A is (a), (b) or (c); U is N or NR; X is CO or CR.sup.2 ; and R, R.sup.1, R.sup.2, R.sup.3, Y and Z are as disclosed in the disclosure.Type: GrantFiled: September 14, 1998Date of Patent: June 27, 2000Assignee: FMC CorporationInventors: George Theodoridis, Lester L. Maravetz, Scott D. Crawford
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Patent number: 6077812Abstract: Novel herbicidal compounds, compositions containing them, and methods for their use in controlling weeds are disclosed. The novel herbicidal compounds are represented by formula I: ##STR1## where J is a 1-substituted-6-trifluoromethyl-2,4-pyrimidinedione-3-yl, a 1-substituted-6-trifluoromethyl-1,3,5-triazine-2,4-dion-1-yl, a 3,4,5,6-tetrahydrophthalimid-1-yl, a 4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-on-1-yl, a 5,6,7,8-tetrahydro-1H,3H-[1,3,4]thiadiazolo[3,5-a]pyridazineimin-1-yl, or a 1,6,8-triazabicyclo[4.3.0]-nonane-7,9-dion-8-yl ring attached at the 7 position of a benzofuran, benzoxazole, indole, 2,3-dihydrobenzimidazole or benzimidazole, and X is selected from hydrogen, halogen, cyano, nitro, and amino. Preferred R groups are optionally substituted alkyl groups.Type: GrantFiled: February 24, 1998Date of Patent: June 20, 2000Assignee: FMC CorporationInventors: Scott D. Crawford, Lester L. Maravetz, George Theodoridis, Benjamin Dugan
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Patent number: 5753595Abstract: Herbicidal 3-(substituted benzoxazol-7-yl) and 3-(substituted benzothiazol-7-yl)-1 -substituted-6-trifluoromethyl-2,4-(1H,3H)pyrimidinediones, compositions containing them, and methods of using them to control undesired plant growth are disclosed, as are novel intermediates used in the preparation of these compounds. The herbicidal compounds of the present invention are defined by the following generic structure: ##STR1## in which R is selected from a variety of substituents, including halogen, alkyl, alkenyl, alkynyl, phenyl, phenylalkyl, alkylphenylalkyl, haloalkyl, hydroxy, alkoxy, hydroxyalkyl, halophenyl, halophenylalkyl, alkoxyphenyl, sulfhydryl, alkylthio, piperidinyl, alkylamino, alkoxyalkyl, phenoxy, amino, alkylsulfonylamino, phenylsulfonylamino, and carboxy; R.sup.1 is alkyl or amino; R.sup.Type: GrantFiled: July 31, 1996Date of Patent: May 19, 1998Assignee: FMC CorporationInventors: Scott D. Crawford, Lester L. Maravetz, George Theodoridis
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Patent number: 5661108Abstract: Herbicidal 3-(bicyclic nitrogen-containing heterocycle)-substituted-1-methyl-6-trifluoromethyluracils, compositions containing them, and methods of using them to control undesired plant growth are disclosed. The herbicidal compounds of the present invention are defined by the following generic structure: ##STR1## in which V is N or C--R.sup.1 ; R is hydrogen, straight or branched chain alkyl, alkenyl, alkynyl, hydroxyalkyl, alkoxyalkyl, haloalkyl, alkoxycarbonylalkyl, arylalkyl, optionally substituted with halogen, or aminocarbonylalkyl in which the amino nitrogen is substituted with arylalkyl or one or two alkyl; R.sup.1 is hydrogen, alkyl, haloalkyl, or cyano; R.sup.2 is lower alkyl or amino; and X is hydrogen or halogen, with the proviso that each aliphatic component has not more than six carbon atoms.Type: GrantFiled: January 18, 1995Date of Patent: August 26, 1997Assignee: FMC CorporationInventors: Scott D. Crawford, Lester L. Maravetz, George Theodoridis
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Patent number: 5321002Abstract: Herbicidal compounds, compositions containing them, and a method for controlling weeds by application of the compositions are disclosed. The herbicidal compounds are 2-(1-aryl-4-cyano-5-pyrazolylmethyleneiminooxy)alkanoic acid derivatives of the structure: ##STR1## in which R is lower alkyl, lower alkenyl, or lower alkynyl, each optionally substituted with halogen, or CH(R.sup.1)--C(O)--Y--R.sup.2 ; R.sup.1 is hydrogen or lower alkyl; R.sup.2 is one of a variety of substituents; Y is O or NH; Z is lower alkyl or lower alkoxy; and Ar is 3-chloro-5-trifluoromethyl-2-pyridyl, 2,6-dichloro-4-trifluoromethylphenyl, or 2,4,6-trichlorophenyl.Type: GrantFiled: August 11, 1993Date of Patent: June 14, 1994Assignee: FMC CorporationInventor: Lester L. Maravetz
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Patent number: 5262382Abstract: This application discloses herbicidal 1-arylpyrazoles, compositions containing them, methods of preparing them, and methods for controlling undesired plant growth by preemergent or postemergent application of the herbicidal compositions to the locus where control is desired. The herbicidal compounds have the following generic structure: ##STR1## in which Ar is ##STR2## R is chlorine, cyano, or nitro; R.sup.1 is a group --C(O)CR.sup.11 R.sup.12 --O--R.sup.13 in which R.sup.11 and R.sup.12 are independently hydrogen or alkyl; R.sup.13 is hydrogen, alkylcarbonyl, phenylcarbonyl, phenylmethyl, or alkylaminosulfonyl; R.sup.2 is hydrogen, alkyl, alkylcarbonyl, alkoxycarbonyl, or a group --C(O)CR.sup.11 R.sup.12 --O--R.sup.13 ; R.sup.3, R.sup.4, R.sup.6, R.sup.7 are independently hydrogen or halogen; R.sup.5 is halogen or haloalkyl; R.sup.8 is halogen; R.sup.9 is haloalkyl; R.sup.10 is hydrogen, halogen, or a group --NR.sup.14 R.sup.15 in which R.sup.14 is hydrogen or alkyl; R.sup.Type: GrantFiled: September 4, 1992Date of Patent: November 16, 1993Assignee: FMC CorporationInventor: Lester L. Maravetz
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Patent number: 5250504Abstract: This application discloses herbicidal .beta.-pyrazolylacrylic acids, compositions containing them, methods of preparing them, and methods for controlling undesired plant growth by preemergent or postemergent application of the herbicidal compositions to the locus where control is desired. The herbicidal compounds have the formula ##STR1## in which X is chlorine or fluorine, X.sup.1 is hydrogen, chlorine, or fluorine, X.sup.2 is chlorine, fluorine, trifluoromethyl, or ethoxy, and X.sup.3 is hydrogen, chlorine, or fluorine; M is --CH--, --CF--, or --CCl--; and R.sup.1 is --CH.dbd.C(--R.sup.2)--C(.dbd.O)--Z--[S(O).sub.2 ].sub.n --R.sup.3 in which R.sup.2 is hydrogen or methyl; R.sup.3 is hydrogen, lower alkyl, or phenylmethyl optionally substituted with one or more of chlorine, bromine, fluorine, or methyl; Z is --O--, --S-- or --NR.sup.4 ; and n is 0 or 1; provided that when Z is --O-- or --S--, n is 0.Type: GrantFiled: January 29, 1993Date of Patent: October 5, 1993Assignee: FMC CorporationInventor: Lester L. Maravetz
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Patent number: 5198014Abstract: This application discloses hebricidal B-pyrazolylacrylic acids, compositions containing them, methods of preparing them, and methods for controlling undesired plant growth by preemergent or postemergent application of the herbicidal compositions to the locus where control is desired. The herbicidal compounds have the formula ##STR1## in which the radicals are defined in the claims.Type: GrantFiled: November 20, 1991Date of Patent: March 30, 1993Assignee: FMC CorporationInventor: Lester L. Maravetz
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Patent number: 5167691Abstract: This application discloses herbicidal 1-aryl-pyrazoles, compositions containing them, methods of preparing them, and methods for controlling undesired plant growth by preemergent or postemergent application of the herbicidal compositions to the locus where control is desired. The herbicidal compounds have the following generic structure: ##STR1## in which Ar is ##STR2## R is chlorine, cyano, or nitro; R.sup.1 is a group --C(O)CR.sup.11 R.sup.12 --O--R.sup.13 in which R.sup.11 and R.sup.12 are independently hydrogen or alkyl; R.sup.13 is hydrogen, alkylcarbonyl, phenylcarbonyl, phenylmethyl, or alkylaminosulfonyl; R.sup.2 is hydrogen, alkyl, alkylcarbonyl, alkoxycarbonyl, or a group --C(O)CR.sup.11 R.sup.12 --O--R.sup.13 ; R.sup.3, R.sup.4, R.sup.6, R.sup.7 are independently hydrogen or halogen; R.sup.5 is halogen or haloalkyl; R.sup.8 is halogen; R.sup.9 is haloalkyl; R.sup.10 is hydrogen, halogen, or a group --NR.sup.14 R.sup.15 in which R.sup.14 is hydrogen or alkyl; R.sub.Type: GrantFiled: October 3, 1991Date of Patent: December 1, 1992Assignee: FMC CorporationInventor: Lester L. Maravetz
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Patent number: 4919708Abstract: Herbicidal 1-aryl-1,2,4-triazolin-5(1H)-ones having a haloalkyl group (e.g. CHF.sub.2, CF.sub.3 or CClF.sub.2) attached to the carbon atom at the 3-position of the triazolinone ring.Type: GrantFiled: June 26, 1989Date of Patent: April 24, 1990Assignee: FMC CorporationInventor: Lester L. Maravetz
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Patent number: 4906287Abstract: Herbicidal 2-aryl-1,2,4-triazine-3,5(2H,4H)-diones, the corresponding 2-aryldihydro-1,2,4-triazine-3,5-diones and sulfur analogs of said diones.Type: GrantFiled: March 5, 1987Date of Patent: March 6, 1990Assignee: FMC CorporationInventors: John W. Lyga, George Theodoridis, Lester L. Maravetz
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Patent number: H1942Abstract: Novel herbicidal compounds, compositions containing them, and methods for their preparation and use in controlling weeds are disclosed. The novel herbicidal compounds are 3-(pyrazolylphenyl)propanoic acids and derivatives having the formula: wherein X is H or halogen; Y is halogen, trihaloalkyl or cyano; Z and R are halogen; R1 is carboxyl or agriculturally acceptable salt thereof, cyano, alkoxycarbonyl, alkylthiocarbonyl, alkoxyalkoxycarbonyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, or alkylsulfonylaminocarbonyl; and R2 is hydrogen or lower alkyl.Type: GrantFiled: September 1, 1998Date of Patent: February 6, 2001Assignee: FMC CorporationInventors: George Theodoridis, Scott D. Crawford, Lester L. Maravetz
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Patent number: H1759Abstract: It has now been found that certain novel benzyloxyphenyl-substituted heterocycles are useful as pre-emergent and post-emergent herbicides. These compounds are represented by formula I: ##STR1## where Q is 1-substituted-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedion-3 -yl, 4-difluoromethyl-4,5-dihydro-3-methyl-1,2,4-triazol-5(1H)-on-1-yl, 4-halo-5-difluoromethoxy-1-methylpyrazol-3-yl, a 3,4,5,6-tetrahydrophthalimid-1-yl, 8-thia-1,6-diazabicyclo?4.3.0!-nonane-7-on-9-iminoyl, 4-methyl-1,2,4-triazine-3,5-dion-2-yl, 3-chloro-4,5,6,7-tetrahydroindazol-2-yl, 1,4-dihydro-4-(3-fluoropropyl)-5H-tetrazole-5-on-1-yl or a 5,6,7,8-tetrahydro-1,2,4-triazolo-?4,3-a!pyridin-3(2H)-on-2-yl moiety; Z is oxygen, sulfur or CH.sub.2 ; n is 0 or 1, and W, X, Y, R, and R.sup.1 are as described in the specification. Preferred are those compounds where W is oxygen; X is hydrogen or fluoro; Y is methyl or ethyl; n is 1; Z is oxygen; R is methyl; and R.sup.1 is hydroxyalkyl or CH.sub.2 OCONHCH.sub.3.Type: GrantFiled: May 22, 1998Date of Patent: November 3, 1998Assignee: FMC CorporationInventors: George Theodoridis, Scott D. Crawford, Lester L. Maravetz, Saroj Sehgel, Dominic Suarez
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Patent number: H1923Abstract: It has now been found that certain novel (oxaalkyl)phenyl-substituted heterocycles are useful as pre-emergent and post-emergent herbicides. These compounds are represented by formula I: ##STR1## where Q is a heterocycle and X, Y, R, R.sup.1, R.sup.2, and R.sup.3 are substituents as described in the specification. Preferred are those compounds where Y and R are chloro; R.sup.1 and R.sup.2 are hydrogen or methyl; R.sup.3 is hydrogen or alkylaminocarbonyl; X is fluorine; and Q is a 1-substituted-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedion-3-yl.Type: GrantFiled: July 10, 1998Date of Patent: November 7, 2000Assignee: FMC CorporationInventors: George Theodoridis, Scott D. Crawford, Lester L. Maravetz