Abstract: A dynamic interference lithography (DIL) device is provided. The device includes a laser source configured for providing a laser beam, a substrate stage configured for mounting a substrate, an at least partially convex curved mirror, and a spatial filter configured to divide the laser beam into a first beam portion directed towards the at least partially convex curved mirror and a second beam portion directed towards the substrate. The first beam portion is reflected by the at least partially convex curved mirror towards the substrate to form an interference pattern on the substrate.

Abstract: A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein.

Abstract: Provided are biodegradable 3D porous hybrid protein (3D-PHP) nanoscaffolds that comprise MnO2 nanosheets and avoid covalent modification of proteins. These nanoscaffolds demonstrate inflammatory stimuli-responsive drug release as well as disc-mimetic stiffness. Also provided are methods of using (e.g., treating intervertebral disc disease (IVDD)) and manufacturing such nanoscaffolds.

Abstract: The invention relates to biodegradable nanoscaffolds, e.g. low dimension manganese oxide (MnO2)-based nanoscaffolds containing ECM proteins and/or cationic polymers, and methods of use and manufacture thereof.

Abstract: Compositions comprising biologically active synthetic nanoparticle constructs and methods of use thereof to modify mitochondrial gene expression including transcriptional repression and transcriptional activation.

Abstract: The bio-microbur therapeutic delivery platform is a three-dimensional (3D)-oriented nanoneedle platform shaped like a microscale version of a fruit bur. The bio-microbur may be used for drug delivery and other biological applications, including without limitation delivery of oral vaccines or other oral biologics. Similar to a fruit bur's ability to adhere to different surfaces, the bio-microbur therapeutic delivery platform adheres to biological tissue, cell membranes, and biological gels. The bio-microbur therapeutic delivery platform includes a core and a plurality of nanoneedles secured to the core and extending outwardly therefrom, adapted for carrying and delivering a therapeutic agent. The treating agent may be an SSRI, such as fluoxetine.

Abstract: The hybrid nanoporous membranes are assembled from inorganic 3D nanospiky particles and polymers, and can be used to filter, capture, and manipulate environmental or biological substances. These materials provide efficient, continuous filtration of ultrasmall biological substances with sizes less than 100 nm while still maintaining air or fluid flow through the materials.

Abstract: The present disclosure provides, inter alia, compositions and methods for treating or ameliorating the effect of a disorder such as, e.g., anxiety or depression in a subject, with less or no off- and/or on-target side effects. Also provided are methods for treating such disorder in a pregnant woman.

Abstract: A three dimensional scaffold for generating cell or protein assemblies. This degradable scaffold can be applied to various types of cells. Also disclosed are methods of treating a condition by implanting the protein or cell assembly prepared according to the method described herein.

Abstract: A dynamic interference lithography (DIL) device is provided. The device includes a laser source configured for providing a laser beam, a substrate stage configured for mounting a substrate, an at least partially convex curved mirror, and a spatial filter configured to divide the laser beam into a first beam portion directed towards the at least partially convex curved mirror and a second beam portion directed towards the substrate. The first beam portion is reflected by the at least partially convex curved mirror towards the substrate to form an interference pattern on the substrate.

Abstract: A surface-enhanced Raman scattering (SERS) sensing system or platform and methods of using the same, where the platform comprises a graphene coated-homogeneous plasmonic metal hybrid array, which synergizes both electromagnetic mechanism (EM)- and chemical mechanism (CM)-based signal enhancement for achieving sensitive and reproducible detection of Raman signals. The system and methods of using such system or platform may be applied to the analyses of various bio/chemical molecules, such as but not limited to those found in cells, in a highly sensitive and selective manner.

Abstract: Disclosed are spheroidal hybrid biodegradable materials containing low dimensional manganese dioxide (MnO2) support structures and cells, methods of manufacture thereof, and methods of use thereof.

Abstract: The invention relates to biodegradable nanoscaffolds, e.g. low dimension manganese oxide (MnO2)-based nanoscaffolds containing ECM proteins and/or cationic polymers, and methods of use and manufacture thereof.