Abstract: The disclosure provides substituted triazoloheteroaryl compounds as represented in Formula (I) and the use thereof: wherein A1, A2, B1, B2, B3, B4, B5, D1, D2, D3, D4, L, Cy1 and Cy2 are defined herein. The compounds of Formula I are USP1 inhibitors. Therefore, the compounds of the disclosure may be used to treat diseases associated with USP1 regulation, disorders and conditions, such as cancer.

Abstract: A grader and a blade control method wherein the grader includes: a blade mechanism including a blade; a blade adjusting mechanism including a plurality of adjusting means respectively corresponding to at least two degrees of freedom of the blade, and configured to adjust a spatial position and/or angle of the blade; a blade position detecting mechanism configured to detect a slope parameter for characterizing a spatial position of the blade; a motion trajectory library configured to store motion functions of the plurality of adjusting means respectively when different operation conditions and/or different grades are switched; a controller configured to call a corresponding motion function in the motion trajectory library according to a set operation condition and a required slope, and control at least one of the plurality of adjusting means according to a position parameter of the blade and the motion function.

Abstract: Provided are compounds of formula (I), which have KRAS mutation tumor regulating activity. Also provided are a method for providing these compounds and a pharmaceutical composition comprising the same.

Abstract: A plasma-generating nozzle and a plasma device including the plasma-generating nozzle are provided. The plasma-generating nozzle includes a plasma-generating channel, a cooling channel at least partially surrounding the plasma-generating channel, and a pair of electrodes partially disposed in the plasma-generating channel for generating plasma. The plasma device includes a housing enclosing a plasma treatment space and a component space, and the plasma-generating nozzle removable disposed in the plasma treatment space.

Abstract: The present disclosure relates to a grader and a blade control method. The grader includes: a blade mechanism including a blade; a blade adjusting mechanism including a plurality of adjusting means respectively corresponding to at least two degrees of freedom of the blade, and configured to adjust a spatial position and/or angle of the blade; a blade position detecting mechanism configured to detect a slope parameter for characterizing a spatial position of the blade; a motion trajectory library configured to store motion functions of the plurality of adjusting means respectively when different operation conditions and/or different grades are switched; a controller configured to call a corresponding motion function in the motion trajectory library according to a set operation condition and a required slope, and control at least one of the plurality of adjusting means according to a position parameter of the blade and the motion function.