Patents by Inventor Lev T. Perelman
Lev T. Perelman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11931163Abstract: Described herein are embodiments of an approach to diagnosing pancreatic cystic lesions using light scattering spectroscopy. In some embodiments, the approach includes an apparatus including a spatial gating probe to isolate light reflected by the epithelial tissue of the internal cyst surface using spatial gating. In some further embodiments, the apparatus includes a scanning fiber probe that is capable of rotational and linear motion in order to scan the entire internal surface of the cyst. Use of such an approach may be advantageous to improve the accuracy of diagnosing pancreatic cystic lesions as cancerous, precancerous, or benign.Type: GrantFiled: February 23, 2018Date of Patent: March 19, 2024Assignee: Beth Israel Deaconess Medical Center, Inc.Inventor: Lev T. Perelman
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Publication number: 20200297266Abstract: Described herein are embodiments of an approach to diagnosing pancreatic cystic lesions using light scattering spectroscopy. In some embodiments, the approach includes an apparatus including a spatial gating probe to isolate light reflected by the epithelial tissue of the internal cyst surface using spatial gating. In some further embodiments, the apparatus includes a scanning fiber probe that is capable of rotational and linear motion in order to scan the entire internal surface of the cyst. Use of such an approach may be advantageous to improve the accuracy of diagnosing pancreatic cystic lesions as cancerous, precancerous, or benign.Type: ApplicationFiled: February 23, 2018Publication date: September 24, 2020Applicant: Beth Israel Deaconess Medical Center, Inc.Inventor: Lev T. Perelman
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Patent number: 9788728Abstract: Method and system for early detection of precancerous and other abnormal changes in tissue of various organs. The system comprises a combination of endoscopic scanning with light scattering spectroscopy and improves detection of abnormalities that may otherwise remain undetected. The system may include a probe that collects data of quality that is independent of a distance of the probe from the scanned tissue. During endoscopy, tissue of an organ is imaged using polarized multispectral light scattering scanning and results are presented to a user in a manner that allows detecting abnormal morphological and biochemical changes in the tissue. A determination of whether to perform biopsy may be performed while the endoscopy is being performed, which thus provides guided biopsy. An entire surface of the organ may be rapidly scanned and results of the scanning are analyzed with a reduced time delay.Type: GrantFiled: January 22, 2010Date of Patent: October 17, 2017Assignee: Beth Israel Deaconess Medical Center, Inc.Inventor: Lev T. Perelman
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Patent number: 8634067Abstract: Apparatus including a broadband illumination source and a confocal optical system. The confocal optical system is configured and arranged to receive a portion of light projected onto an object by the broadband illumination source. The apparatus can include an illumination source, a confocal optical system, and at least one detector configured and arranged to receive angularly separated light corresponding to a confocal volume. There is also provided a light scattering spectroscopic device including a broadband illumination source, a two-dimensional detector, and a spectral separation device configured and arranged to receive scattered light from an object and to direct at least a portion of the scattered light onto the two-dimensional detector. The method and apparatus can combine confocal microscopy techniques with light scattering spectroscopy techniques to create a confocal light scattering spectroscopy (CLSS) system.Type: GrantFiled: May 11, 2005Date of Patent: January 21, 2014Assignee: Beth Israel Deaconess Medical Center, Inc.Inventors: Lev T. Perelman, Juan G. Alvarez, Mark D. Modell
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Publication number: 20120041290Abstract: Method and system for early detection of precancerous and other abnormal changes in tissue of various organs. The system comprises a combination of endoscopic scanning with light scattering spectroscopy and improves detection of abnormalities that may otherwise remain undetected. The system may include a probe that collects data of quality that is independent of a distance of the probe from the scanned tissue. During endoscopy, tissue of an organ is imaged using polarized multispectral light scattering scanning and results are presented to a user in a manner that allows detecting abnormal morphological and biochemical changes in the tissue. A determination of whether to perform biopsy may be performed while the endoscopy is being performed, which thus provides guided biopsy. An entire surface of the organ may be rapidly scanned and results of the scanning are analyzed with a reduced time delay.Type: ApplicationFiled: January 22, 2010Publication date: February 16, 2012Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER, INCInventor: Lev T. Perelman
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Publication number: 20110122487Abstract: Apparatus including a broadband illumination source and a confocal optical system. The confocal optical system is configured and arranged to receive a portion of light projected onto an object by the broadband illumination source. The apparatus can include an illumination source, a confocal optical system, and at least one detector configured and arranged to receive angularly separated light corresponding to a confocal volume. There is also provided a light scattering spectroscopic device including a broadband illumination source, a two-dimensional detector, and a spectral separation device configured and arranged to receive scattered light from an object and to direct at least a portion of the scattered light onto the two-dimensional detector. The method and apparatus can combine confocal microscopy techniques with light scattering spectroscopy techniques to create a confocal light scattering spectroscopy (CLSS) system.Type: ApplicationFiled: May 11, 2005Publication date: May 26, 2011Applicant: Beth Israel Deaconess Medical Center, Inc.Inventors: Lev T. Perelman, Juan G. Alvarez, Mark Modell
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Patent number: 6922583Abstract: The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.Type: GrantFiled: April 10, 2000Date of Patent: July 26, 2005Assignee: Massachusetts Institute of TechnologyInventors: Lev T. Perelman, Vadim Backman, Michael S. Feld, George Zonios, Irving Itzkan, Ramasamy Manoharan
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Patent number: 6847456Abstract: The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.Type: GrantFiled: April 27, 2001Date of Patent: January 25, 2005Assignee: Massachusetts Institute of TechnologyInventors: Changhuei Yang, Adam P. Wax, Lev T. Perelman, Ramachandra R. Dasari, Michael S. Feld
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Publication number: 20030065268Abstract: Photon migration methods are employed to image absorbing objects embedded in a turbid medium such as tissue. For improved resolution, early arriving photons are detected to provide data with image reconstruction based on optical computed tomography (CT). The CT method is generalized to take into account the distributions of photon paths. A point spread function (PSF) is expressed in terms of the Green's function for the transport equation. This PSF provides weighting functions for use in a generalized series expansion method. Measurements of turbid medium with scattering and absorption properties included coaxial transmission scans collected in two projections. Blurring associated with multiple scattering was removed and high-resolution images can be obtained.Type: ApplicationFiled: May 4, 2001Publication date: April 3, 2003Applicant: Massachusetts Institute of TechnologyInventors: Kun Chen, Lev T. Perelman, Qingguo Zhang, Ramachandra R. Dasari, Michael S. Feld
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Publication number: 20020101593Abstract: The present invention relates to systems and methods of field-based light scattering spectroscopy. These systems and methods provide for the diagnosis of tissue by measuring the size and distribution of cellular characteristics. Field based measurements provide phase information resulting from the interaction of scatterers within the material and the incident wavefront. These measurements can be used to provide three dimensional images of tissue.Type: ApplicationFiled: April 27, 2001Publication date: August 1, 2002Applicant: Massachusetts Institute of TechnologyInventors: Changhuei Yang, Adam P. Wax, Lev T. Perelman, Ramachandra R. Dasari, Michael S. Feld
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Patent number: 6321111Abstract: The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.Type: GrantFiled: July 2, 1999Date of Patent: November 20, 2001Assignee: Massachusetts Institute of TechnologyInventors: Lev T. Perelman, Jun Wu, Yang Wang, Ramachandra Rac Dasari, Irving Itzkan, Michael S. Feld
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Patent number: 6091984Abstract: The present invention relates to systems and methods for measuring one or more physical characteristics of material such as tissue using optical radiation. The system can use light that is scattered by a tissue layer to determine, for example, the size of nuclei in the tissue layer to aid in the characterization of the tissue. These methods can include the use of fiber optic devices to deliver and collect light from a tissue region of interest to diagnose, for example, whether the tissue is normal or precancerous.Type: GrantFiled: October 10, 1997Date of Patent: July 18, 2000Assignee: Massachusetts Institute of TechnologyInventors: Lev T. Perelman, Vadim Backman, Michael S. Feld, George Zonios, Irving Itzkan, Ramasamy Manoharan
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Patent number: 6070583Abstract: The present invention relates to the use of inelastically scattered light, particularly fluorescent and Raman scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions as well as histological information that can be used for diagnosing disease and various medical conditions.Type: GrantFiled: February 21, 1995Date of Patent: June 6, 2000Assignee: Massachusetts Institute of TechnologyInventors: Lev T. Perelman, Jun Wu, Yang Wang, Ramachandra Roa Dasari, Irving Itzkan, Michael S. Feld
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Patent number: 5919140Abstract: The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.Type: GrantFiled: October 27, 1995Date of Patent: July 6, 1999Assignee: Massachusetts Institute of TechnologyInventors: Lev T. Perelman, Jun Wu, Yang Wang, Ramachandra Rao Dasari, Irving Itzkan, Michael S. Feld