Patents by Inventor Levava Roiz

Levava Roiz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ACTIN BINDING PEPTIDES AND COMPOSITIONS COMPRISING SAME FOR INHIBITING ANGIOGENESIS AND TREATING MEDICAL CONDITIONS ASSOCIATED WITH SAME
    Publication number: 20160340659
    Abstract: The present invention, in some embodiments thereof, relates to biologically active peptides and, more particularly, but not exclusively, to peptides from T2 RNase (RNASET2) having actin binding, pharmaceutical compositions comprising the same, therapeutic use thereof and methods for their production.
    Type: Application
    Filed: January 29, 2015
    Publication date: November 24, 2016
    Inventors: Oded SHOSEYOV, Betty SCHWARTZ, Shani DORON, Liron NESIEL, Assaf FRIEDLER, Hadar AMARTELY, Levava ROIZ, Patricia SMIRNOFF, Iris LEWIN
  • Methods of and compositions for inhibiting the proliferation of mammalian cells
    Patent number: 8735127
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Grant
    Filed: September 9, 2013
    Date of Patent: May 27, 2014
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • METHODS OF AND COMPOSITIONS FOR INHIBITING THE PROLIFERATION OF MAMMALIAN CELLS
    Publication number: 20140011729
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Application
    Filed: September 9, 2013
    Publication date: January 9, 2014
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava ROIZ, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Methods of and compositions for inhibiting the proliferation of mammalian cells
    Patent number: 8617867
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Grant
    Filed: January 1, 2012
    Date of Patent: December 31, 2013
    Assignee: Yissum Research Develpment Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Methods of and compositions for inhibiting the proliferation of mammalian cells
    Patent number: 8236543
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Grant
    Filed: September 27, 2010
    Date of Patent: August 7, 2012
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • METHODS OF AND COMPOSITIONS FOR INHIBITING THE PROLIFERATION OF MAMMALIAN CELLS
    Publication number: 20120100128
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Application
    Filed: January 1, 2012
    Publication date: April 26, 2012
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Recombinant human T2 RNase and uses thereof
    Patent number: 8039240
    Abstract: The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The methods are effected by administering to the subject a therapeutically effective amount of a RNase6PL ribonuclease or close homologues thereof.
    Type: Grant
    Filed: September 28, 2005
    Date of Patent: October 18, 2011
    Assignee: Yissum Reseach Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • EFFICIENT EXPRESSION OF TRUNCATED HUMAN RNASET2 IN E. COLI
    Publication number: 20110207667
    Abstract: An isolated, recombinant truncated human RNASET2 having anti-angiogenic properties, methods for efficient expression thereof in bacteria and therapeutic uses thereof.
    Type: Application
    Filed: October 29, 2009
    Publication date: August 25, 2011
    Inventors: Oded Shoseyou, Betty Schwartz, Levava Roiz, Patricia Smirnoff, Liron Nuttman
  • METHODS OF AND COMPOSITIONS FOR INHIBITING THE PROLIFERATION OF MAMMALIAN CELLS
    Publication number: 20110008314
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Application
    Filed: September 27, 2010
    Publication date: January 13, 2011
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Methods of and compositions for inhibiting the proliferation of mammalian cells
    Patent number: 7811981
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Grant
    Filed: September 29, 2004
    Date of Patent: October 12, 2010
    Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Recombinant Human T2 Rnase and Uses Thereof
    Publication number: 20080131419
    Abstract: The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The methods are effected by administering to the subject a therapeutically effective amount of a RNase6PL ribonuclease or close homologues thereof.
    Type: Application
    Filed: September 28, 2005
    Publication date: June 5, 2008
    Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Methods of and compositions for inhibiting the proliferation of mammalian cells
    Publication number: 20050113327
    Abstract: A method of preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation and/or development of abnormal cells in a subject is disclosed. The method is effected by administering to the subject a therapeutically effective amount of a ribonuclease of the T2 family having actin binding activity.
    Type: Application
    Filed: September 29, 2004
    Publication date: May 26, 2005
    Inventors: Levava Roiz, Betty Schwartz, Patricia Smirnoff, Oded Shoseyov
  • Method for the biological control of pollen in plants
    Patent number: 5552139
    Abstract: A method for the biological control of pollen in plants, including the thinning of fruits, reducing seeds in citrus plants and reducing the incidence of shotberries in grapes, by applying an effective amount of activated or inactivated RNase or mixtures of these to the flowers of the plants.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: September 3, 1996
    Assignee: Yissum Research Development Co. of the Hebrew University of Jerusalem
    Inventors: Oded Shoseyov, Levava Roiz, Uzi Ozeri, Ben-Ami Bravdo, Raphael Goren