Patents by Inventor Levente Ondi
Levente Ondi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230013959Abstract: The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: wherein: M is a Group 6 metal atom; X is an oxygen atom, ?N—R5, ?N—N(R5)(R5?) or ?N—O—R5, R5 and R5? independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Rz is a neutral ligand; R1 is hydrogen or an organic substituent; R2 is an aryl or heteroaryl group, each optionally substituted; R3 is an anionic ligand; and R4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.Type: ApplicationFiled: June 28, 2022Publication date: January 19, 2023Inventors: Florian Toth, Georg Frater, Levente Ondi
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Patent number: 11414446Abstract: The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: wherein: M is a Group 6 metal atom; X is an oxygen atom, ?N—R5, ?N—N(R5)(R5?) or ?N—O—R5, R5 and R5? independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Rz is a neutral ligand; R1 is hydrogen or an organic substituent; R2 is an aryl or heteroaryl group, each optionally substituted; R3 is an anionic ligand; and R4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.Type: GrantFiled: August 7, 2020Date of Patent: August 16, 2022Inventors: Florian Toth, Georg Frater, Levente Ondi
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Publication number: 20220227797Abstract: The invention relates to tungsten imido alkylidene compounds bearing a ligand derived from a 1,1?-binaphthyl-2-ol or a 5,5?,6,6?,7,7?,8,8?-octahydro-1,1?-binaphthyl-2-ol which bind to tungsten in its olate-form via proton abstraction from the phenolic OH group. The complexes may be used in various olefinic metathesis reactions, preferably ethenolysis and cross-metathesis of unsaturated fatty acid esters, and ring-closing metathesis reactions.Type: ApplicationFiled: May 27, 2020Publication date: July 21, 2022Inventors: Levente Ondi, Csaba Hegedüs, Ágota Bucsai, Jeno Varga, Benedek Vakulya, Krisztian Lorincz, Henrik Gulyas, Hasan Mehdi
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Patent number: 11285466Abstract: The invention relates to a method of forming an olefin from a first olefin and a second olefin in a metathesis reaction, comprising step (i): (i) reacting the first olefin with the second olefin in the presence of a compound that catalyzes said metathesis reaction such that the molar ratio of said compound to the first or the second olefin is from 1:500 or less, and the conversion of the first or the second olefin to said olefin is at least 50%, characterized in that as compound that catalyzes said metathesis reaction a compound of the following formula is used: wherein M is Mo or W; R1 is aryl, heteroaryl, alkyl, or heteroalkyl; optionally substituted; R2 and R3 can be the same or different and are hydrogen, alkyl, alkenyl, heteroalkyl, heteroalkenyl, aryl, or heteroaryl; optionally substituted; R5 is alkyl, alkoxy, heteroalkyl, aryl, heteroaryl, silylalkyl, silyloxy, optionally substituted; and R4 is a residue R6—X—, wherein X?O and R6 is aryl, optionally substituted; or X?S and R6 is aryl, optType: GrantFiled: June 12, 2019Date of Patent: March 29, 2022Assignee: Verbio Vereinigte Bioenergie AGInventors: Levente Ondi, Jeno Varga, Agota Bucsai, Florian Toth, Krisztian Lorincz, Csaba Hegedus, Emmanuel Robe, Georg Emil Frater
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Patent number: 11155505Abstract: Methods for preparation of olefins, including 8- and 11-unsaturated monoenes and polyenes, via transition metathesis-based synthetic routes are described. Metathesis reactions in the methods are catalyzed by transition metal catalysts including tungsten-, molybdenum-, and ruthenium-based catalysts. The olefins include insect pheromones useful in a number of agricultural applications.Type: GrantFiled: August 16, 2019Date of Patent: October 26, 2021Assignee: PROVIVI, INC.Inventors: Keith M. Wampler, Vu Bui, David Rozzell, Pedro Coelho, Arthur Floruti, Levente Ondi, Hasan Mehdi, Gabor Eros
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Patent number: 11077433Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: GrantFiled: February 24, 2020Date of Patent: August 3, 2021Assignee: PROVIVI, INC.Inventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Levente Ondi, Hasan Mehdi
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Publication number: 20210206788Abstract: A compound of formula (I) wherein: M is selected from Mo or W; X is selected from O or NR5; R1 and R2 are independently selected from H, C1-6 alkyl, and aryl; C1-6 alkyl and aryl optionally being substituted with one or more of C1-6 alkyl, C1-6 alkoxy, and O—C6H5; R3 is selected from a nitrogen-containing aromatic heterocycle being bound to M via said nitrogen; and from halogen; R4 is an aryl oxy group being bound to M via said oxygen of said aryl oxy group; wherein said aryl group Ar of said aryl oxy group is bound to a group Cat such to form a cationic ligand Cat+-Z—ArO—, wherein Z is either a covalent bond or a linker; R5 is alkyl or aryl, optionally substituted.Type: ApplicationFiled: May 31, 2019Publication date: July 8, 2021Inventors: Levente Ondi, Roman Schowner, Michael R. Buchmeiser, Iris Elser, Florian Toth, Emmanuel Robe, Benedek Vakulya
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Publication number: 20200261898Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: ApplicationFiled: February 24, 2020Publication date: August 20, 2020Applicant: Provivi, Inc.Inventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Levente Ondi, Hasan Mehdi
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Patent number: 10618909Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.Type: GrantFiled: April 25, 2019Date of Patent: April 14, 2020Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTDInventors: Balázs Bálint, Márton Csékei, Zoltán Szabó, Zoltán Szlávik, András Kotschy, Maïa Chanrion, Olivier Geneste, I-Jen Chen, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Levente Ondi, Ágnes Proszenyák
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Patent number: 10596562Abstract: In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R1 is independently selected from H, C1-18 alkyl, and C2-18 alkenyl; R2b is C1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.Type: GrantFiled: September 29, 2017Date of Patent: March 24, 2020Assignee: PROVIVI, INC.Inventors: Keith M. Wampler, Peter Meinhold, Pedro Coelho, Vu Bui, Levente Ondi, Hasan Mehdi
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Publication number: 20200039900Abstract: Methods for preparation of olefins, including 8- and 11-unsaturated monoenes and polyenes, via transition metathesis-based synthetic routes are described. Metathesis reactions in the methods are catalyzed by transition metal catalysts including tungsten-, molybdenum-, and ruthenium-based catalysts. The olefins include insect pheromones useful in a number of agricultural applications.Type: ApplicationFiled: August 16, 2019Publication date: February 6, 2020Applicant: Provivi, Inc.Inventors: Keith M. Wampler, Vu Bui, David Rozzell, Pedro Coelho, Arthur Floruti, Levente Ondi, Hasan Mehdi, Gabor Eros
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Publication number: 20190366318Abstract: The invention relates to a method of forming an olefin from a first olefin and a second olefin in a metathesis reaction, comprising step (i): (i) reacting the first olefin with the second olefin in the presence of a compound that catalyzes said metathesis reaction such that the molar ratio of said compound to the first or the second olefin is from 1:500 or less, and the conversion of the first or the second olefin to said olefin is at least 50%, characterized in that as compound that catalyzes said metathesis reaction a compound of the following formula is used: wherein M is Mo or W; R1 is aryl, heteroaryl, alkyl, or heteroalkyl; optionally substituted; R2 and R3 can be the same or different and are hydrogen, alkyl, alkenyl, heteroalkyl, heteroalkenyl, aryl, or heteroaryl; optionally substituted; R5 is alkyl, alkoxy, heteroalkyl, aryl, heteroaryl, silylalkyl, silyloxy, optionally substituted; and R4 is a residue R6—X—, wherein X=O and R6 is aryl, optionally substituted; or X=S and R6 is aryl, optType: ApplicationFiled: June 12, 2019Publication date: December 5, 2019Inventors: Levente Ondi, Jeno Varga, Agota Bucsai, Florian Toth, Krisztian Lorincz, Csaba Hegedus, Emmanuel Robe, Georg Emil Frater
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Patent number: 10457687Abstract: Compounds of formula (I): wherein R1, R2, R5, R6, R7, R12, X, Y, A, E and n are as defined in the description. Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.Type: GrantFiled: June 22, 2016Date of Patent: October 29, 2019Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTDInventors: Zoltán Szlávik, Zoltán Szabó, Márton Csékei, Attila Paczal, András Kotschy, Alain Bruno, Olivier Geneste, I-Jen Chen, James Edward Paul Davidson, James Brooke Murray, Levente Ondi, Gábor Radics, Szabolcs Sipos, Ágnes Proszenyák, Françoise Perron-Sierra, Balázs Bálint
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Publication number: 20190248805Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.Type: ApplicationFiled: April 25, 2019Publication date: August 15, 2019Inventors: Balázs Bálint, Márton Csékei, Zoltán Szabó, Zoltán Szlávik, András Kotschy, Maïa Chanrion, Olivier Geneste, I-Jen Chen, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Levente Ondi, Ágnes Proszenyák
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Patent number: 10343153Abstract: A method is provided of forming an olefin from a first olefin and a second olefin in a metathesis reaction, comprising reacting the first olefin with the second olefin in the presence of a compound that catalyzes the metathesis reaction such that the molar ratio of the compound to the first or the second olefin is from 1:500 or less, and the conversion of the first or the second olefin to the olefin is at least 30%.Type: GrantFiled: March 13, 2014Date of Patent: July 9, 2019Assignee: XiMo AGInventors: Levente Ondi, Jeno Varga, Agota Bucsai, Florian Toth, Krisztian Lorincz, Csaba Hegedus, Emmanuel Robe, Georg Emil Frater
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Patent number: 10323041Abstract: Compounds of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, R8, R14, W, A and n are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring a pro-apoptotic agent.Type: GrantFiled: June 22, 2016Date of Patent: June 18, 2019Assignees: LES LABORATOIRES SERVIER, VERNALIS (R&D) LTDInventors: Balazs Balint, Márton Csékei, Zoltán Szabó, Zoltan Szlavik, András Kotschy, Maïa Chanrion, Olivier Geneste, I-Jen Chen, James Edward Paul Davidson, James Brooke Murray, Szabolcs Sipos, Levente Ondi, Ágnes Proszenyák
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Publication number: 20190119311Abstract: The disclosure provides Group 6 complexes, which, in some embodiments, are useful for catalyzing olefin metathesis reactions. In some embodiments, the compounds are compounds of the following formula: wherein: M is a Group 6 metal atom; X is an oxygen atom, ?N—R5, ?N—N(R5)(R5?) or ?N—O—R5, R5 and R5? independently being various substituents, such as aryl or heteroaryl, each optionally substituted; n is 0 or 1; Rz is a neutral ligand; R1 is hydrogen or an organic substituent; R2 is an aryl or heteroaryl group, each optionally substituted; R3 is an anionic ligand; and R4 is an anionic ligand, such as a pyrrolide, a pyrazolide, an imidazolide, an indolide, an azaindolide, or an indazolide, each optionally substituted.Type: ApplicationFiled: October 22, 2018Publication date: April 25, 2019Inventors: Florian Toth, Georg Frater, Levente Ondi
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Publication number: 20190100504Abstract: A method of forming a macrocyclic musk compound comprising the steps of: — i) cross-metathesizing a first olefin and a second olefin in the presence of a homogeneous transition metal catalyst comprising an alkylidene ligand, to form a statistical mixture of a hetero-dimer intermediate of said first and second terminal olefin, and homo-dimers ii) separating the hetero-dimer from the statistical mixture of hetero- and homo-dimers iii) and cyclizing the hetero-dimer intermediate to form the macrocyclic musk compound.Type: ApplicationFiled: November 30, 2018Publication date: April 4, 2019Applicant: GIVAUDAN S.A.Inventors: Paul Nicholas DAVEY, Martin Alan LOVCHIK, Andreas GOEKE, Krisztian LORINCZ, Florian TOTH, Levente ONDI
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Publication number: 20190031675Abstract: Compounds of formula (I): wherein R1, R2, R5, R6, R7, R12, X, Y, A, E and n are as defined in the description. Medicinal products containing the same which are useful in treating a condition requiring a pro-apoptotic agent.Type: ApplicationFiled: June 22, 2016Publication date: January 31, 2019Inventors: Zoltan SZLAVIK, Zoltán SZABÓ, Márton CSÉKEI, Attila PACZAL, András KOTSCHY, Alain BRUNO, Olivier GENESTE, I-Jen CHEN, James Edward Paul DAVIDSON, James Brooke MURRAY, Levente ONDI, Gábor RADICS, Szabolcs SIPOS, Ágnes PROSZENYÁK, Françoise PERRON-SIERRA, Balázs BÁLINT
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Patent number: 10144720Abstract: A method of forming a macrocyclic musk compound comprising the steps of:— i) cross-metathesizing a first olefin and a second olefin in the presence of a homogeneous transition metal catalyst comprising an alkylidene ligand, to form a statistical mixture of a hetero-dimer intermediate of said first and second terminal olefin, and homo-dimers ii) separating the hetero-dimer from the statistical mixture of hetero- and homo-dimers iii) and cyclizing the hetero-dimer intermediate to form the macrocyclic musk compound.Type: GrantFiled: March 13, 2015Date of Patent: December 4, 2018Assignee: GIVAUDAN S.A.Inventors: Paul Nicholas Davey, Martin Alan Lovchik, Andreas Goeke, Krisztian Lorincz, Florian Toth, Levente Ondi