Patents by Inventor Levi Gray-Rupp

Levi Gray-Rupp has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNE CELLS WITH COMBINATION GENE PERTURBATIONS
    Publication number: 20250222103
    Abstract: Provided herein are recombinant nucleic acids that reduce expression of CD5, CBLB, CISH, DGKA, DGKZ, DNMT3A, MAP4K1, NR4A1, PTPN2, TET2, or ZC3H12A and cells comprising such recombinant nucleic acids. Also provided are methods of making and using such cells.
    Type: Application
    Filed: March 14, 2025
    Publication date: July 10, 2025
    Inventors: Adam Litterman, Brenal Singh, John Gagnon, David Detomaso, Ashley Cass, Levi Gray-Rupp, Samuel Williams
  • IMMUNE CELLS HAVING CO-EXPRESSED TGFBR SHRNAS
    Publication number: 20250215438
    Abstract: Provided herein are recombinant nucleic acids that reduce expression of TGFBR1 and/or TGFBR2 and cells comprising such recombinant nucleic acids. Also provided are methods of making and using such cells.
    Type: Application
    Filed: March 11, 2025
    Publication date: July 3, 2025
    Inventors: John Gagnon, Adam Litterman, Amy-Jo Casbon, Brenal Singh, Jason Hall, Natalie Bezman, Aaron Cooper, Levi Gray-Rupp
  • Systems targeting PSMA and CA9
    Patent number: 12257304
    Abstract: Provided herein are antibodies and chimeric priming receptors that bind PSMA and antibodies and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.
    Type: Grant
    Filed: March 1, 2024
    Date of Patent: March 25, 2025
    Assignee: Arsenal Biosciences, Inc.
    Inventors: Angela Boroughs, Levi Gray-Rupp, Samuel A. Williams, Zhen Jian Zhou, Matthew Drever, Duy Nguyen, Amy-Jo Casbon, Anzhi Yao, Thomas Gardner
  • SYSTEMS OF ENGINEERED RECEPTORS TARGETING PSMA AND CA9
    Publication number: 20250082682
    Abstract: Provided herein are chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.
    Type: Application
    Filed: November 14, 2024
    Publication date: March 13, 2025
    Inventors: Angela Boroughs, Levi Gray-Rupp, Jamie Thomas, Bryan Smith, Samuel Williams
  • SYSTEMS TARGETING PSMA AND CA9
    Publication number: 20240342284
    Abstract: Provided herein are antibodies and chimeric priming receptors that bind PSMA and antibodies and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.
    Type: Application
    Filed: March 1, 2024
    Publication date: October 17, 2024
    Inventors: Angela Boroughs, Levi Gray-Rupp, Samuel A. Williams, Zhen Jian Zhou, Matthew Drever, Duy Nguyen, Amy-Jo Casbon, Anzhi Yao, Thomas Gardner
  • COMPOSITIONS AND METHODS FOR QUANTIFYING INTEGRATION OF RECOMBINANT VECTOR NUCLEIC ACID
    Publication number: 20210332448
    Abstract: In certain aspects, the disclosure relates to methods of quantifying integration of a recombinant vector nucleic acid into a target cell's genome. The present disclosure also provides compositions and kits, including particular primers and probes, for performing the quantitation.
    Type: Application
    Filed: March 8, 2021
    Publication date: October 28, 2021
    Inventors: Rajitha Doddareddy, Hsing-Yin Liu, Levi Gray-Rupp, Tong-Yuan Yang