Abstract: An implantable medical device is adapted to be implanted at an implantation site within the vasculature and is capable of being implanted at the implantation site within the vasculature at more than one position relative to the implantation site. This may include a relative axial position and/or a relative rotational position. The implantable medical device includes an expandable frame that is adapted to expand from a collapsed configuration for delivery to an expanded configuration for deployment, and one or more radiopaque markers disposed relative to the expandable frame such that fluoroscopic imaging of the implantable medical device during deployment provides an indication of a position of the implantable medical device relative to the implantation site. The implantable medical device may be a replacement cardiac valve such as a replacement aortic valve, for example.

Abstract: A medical implant for occluding a left atrial appendage may include an expandable framework configured to shift between a collapsed configuration and an expanded configuration, and an occlusive element secured to the expandable framework. The expandable framework includes a proximal hub and a plurality of interconnected struts extending from the proximal hub, the plurality of interconnected struts defining a main body in the expanded configuration. The expandable framework includes a plurality of elongate anchoring appendages extending from the main body, the plurality of elongate anchoring appendages each including a plurality of anchoring barbs extending therefrom.

Abstract: A medical implant for occluding a left atrial appendage includes an expandable framework configured to shift between a first configuration and a second configuration, and an occlusive element secured to the expandable framework. The expandable framework includes a plurality of interconnected struts extending from a proximal hub. The plurality of interconnected struts includes a first plurality of struts and a second plurality of struts. In the second configuration, the first plurality of struts each extend radially along a first strut path from the proximal hub to one of a first plurality of strut intersections, and the second plurality of struts each extend radially along a second strut path from the proximal hub to one of a second plurality of strut intersections. In the second configuration, the first plurality of struts forms a depression in the expandable framework and the second plurality of struts extends into the depression.

Abstract: Coating of at least a portion of components of an implantable device to reduce friction during movement therebetween. The surfaces of the components which are coated may be pretreated in a manner contrary to recommended for application of such coating or may simply not be treated as recommend for application of such coating.