Patents by Inventor Levon Michael Khachigian

Levon Michael Khachigian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TREATMENT METHODS
    Publication number: 20240050444
    Abstract: A method of reducing vascular permeability, neovascularisation, angiogenesis, inflammation, cell migration and/or proliferation, comprising administering an effective amount of an inhibitor of FosB/?FosB expression and/or VCAM-1 expression and/or ERK1/2 phosphorylation, and pharmaceutical compositions and kits comprising inhibitors of FosB/?FosB expression and/or VCAM-1 expression and/or ERK1/2 phosphorylation.
    Type: Application
    Filed: March 12, 2021
    Publication date: February 15, 2024
    Inventor: Levon Michael KHACHIGIAN
  • Agent for targeting c-Jun mRNA
    Patent number: 8686128
    Abstract: The present invention provides a method of preventing or reducing restenosis, neointima formation, graft failure, atherosclerosis, angiogenesis and/or solid tumor growth in a subject. The method comprises administering to the subject a prophylactically effective dose of a nucleic acid which decreases the level of c-Jun mRNA, c-Jun mRNA translation or nuclear accumulation or activity of c-Jun. It is preferred that the nucleic acid is a DNAzyme that targets c-Jun mRNA.
    Type: Grant
    Filed: July 12, 2012
    Date of Patent: April 1, 2014
    Inventor: Levon Michael Khachigian
  • Inhibiting cellular proliferation by expressing yin yang-1
    Patent number: 7541343
    Abstract: The present invention provides a method of preventing or reducing cellular proliferation. The method involves administering to cells a composition which increases the level of YY1 protein, in particular YY1 mRNA, in the cells.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: June 2, 2009
    Assignee: Newsouth Innovations Pty Limited
    Inventor: Levon Michael Khachigian
  • Catalytic molecules
    Patent number: 7355035
    Abstract: The present invention relates to DNAzymes which are targeted against mRNA molecules encoding EGR-1 (also known as Egr-1 and NGFI-A). The present invention also relates to compositions including these DNAzymes and to methods of treatment involving administration of the DNAzymes.
    Type: Grant
    Filed: January 11, 2000
    Date of Patent: April 8, 2008
    Assignee: Unisearch Limited
    Inventors: David G. Atkins, Andrew R. Baker, Levon Michael Khachigian
  • Inhibition of proliferation of cells
    Publication number: 20040072768
    Abstract: The present invention provides a method of screening for compounds which inhibit the proliferation of cells, the method comprising determining the ability of a putative compound to inhibit induction of Egr-1, decrease expression of Egr-1 or decrease the nuclear accumulation or activity of the Egr-1 gene product.
    Type: Application
    Filed: January 9, 2001
    Publication date: April 15, 2004
    Inventor: Levon Michael Khachigian
  • Treatment of cancer
    Publication number: 20030203864
    Abstract: The present invention relates to a method for the treatment of tumours, the method comprising inhibiting angiogenesis in a subject in need thereof chracterised in that angigenesis in inhibited by administering to the subject an agent which inhibist induction of EGR, an agent which decreases the nuclerar accumulation or activity of EGR. The present invention also relates to a method of acreening for agents which inhibits angiogenesis.
    Type: Application
    Filed: April 26, 2002
    Publication date: October 30, 2003
    Inventor: Levon Michael Khachigian
  • Inhibition of proliferation of cells
    Patent number: 6200960
    Abstract: The present invention provides a method of inhibiting the proliferation of cells. The method comprises inhibiting induction or decreasing expression of Egr-1 or decreasing the nuclear accumulation or activity of the Egr-1 gene product. The present invention also provides a method of reducing the incidence of restenosis in a subject. The method comprises administering to the subject an agent which inhibits induction or decreases expression of Egr-1 or decreases the nuclear accumulation or activity of the Egr-1 gene product.
    Type: Grant
    Filed: April 13, 1999
    Date of Patent: March 13, 2001
    Assignee: Unisearch Limited
    Inventor: Levon Michael Khachigian