Abstract: Described herein are methods of preventing cancer, treating cancer, inhibiting tumor growth, predicting patient outcomes, optimizing dosage, and monitoring the efficacy of treatment. In particular, certain microRNAs and messenger RNAs are useful indicators of response to NSAID chemoprevention and therapy of patients having Lynch syndrome or hereditary non-polyposis colorectal cancer.

Abstract: A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their fluorescence. Secreted proteins identifying tumors with specific degrees of malignancy are isolated to determine if they can serve as markers of cancer progression.

Abstract: A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their fluorescence. Secreted proteins identifying tumors with specific degrees of malignancy are isolated to determine if they can serve as markers of cancer progression.

Abstract: Methods are provided herein to determine if a subject is a candidate for treatment with an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR). The method includes determining the presence of at least one polymorphism in the HMGCR gene in a sample from a subject. The presence of at least one polymorphism indicates that the subject is a candidate for treatment with a statin, for example to decrease risk of or treat cancer, cardiovascular disease, diabetes, obesity, inflammatory disease, or auto-immune disease.

Abstract: Compositions, kits, and methods are provided for assessing alterations in gene expression in heterozygous carriers of mutant genes associated with cancer.

Abstract: A method for inducing ER? expression in cancer cells in a subject affected with cancer cells which are ER? (?) is disclosed. The method involves administering to the subject an effective amount of a PPAR? antagonist alone or in combination with anti-estrogen therapy.

Abstract: A method is described to identify secreted proteins identified with stages of malignancy of cancer. The proteins are initially identified by trapping them with a fluorescent protein containing vector that can insert in any gene. The secreted proteins are initially identified by their fluorescence. Secreted proteins identifying tumors with specific degrees of malignancy are isolated to determine if they can serve as markers of cancer progression.

Abstract: This invention relates to cells that demonstrate characteristics of tissue macrophages (CCTM), including all substances obtained therefrom, such CCTM are induced from human fibroblasts (HF) by the Snyder-Theilen feline sarcoma virus (ST:FeSV(FeLV)) and are used for the treatment of immunodeficient states. A method for the de novo induction of cells that demonstrate characteristics of tissue macrophages (CCTM) from human fibroblasts (HF), said method comprising isolating and converting HF cultures from human organs, most conveniently skin, performing transformation assays on said HF cultures by transducing with said ST:FeSV(FeLV)-derived DNA sequences, including the corresponding gene products, to demonstrate conversion of HF to CCTM, and to establish the objects and advantages for the production and use of CCTM and CCTM-associated substances in molecular immunotherapy, somatic cell therapy, and gene therapy.

Abstract: The present invention relates to an improved viral transformation/neodifferentiation assay for determining predisposition to cancer. The invention is based on the association between retroviral transformation/neodifferentiation and a predisposition to cancer. The level of lipogenic enzymes is measured in cultured human fibroblast cells after transformation/neodifferentiation with Kirsten murine sarcoma virus in the presence of glucocorticosteroids to monitor the extent of conversion of the human skin fibroblasts to fully mature adipocytes.