Patents by Inventor Lewis A. Chodosh
Lewis A. Chodosh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200166510Abstract: The present invention provides compositions and methods for detecting and isolating disseminated tumor cells (DTCs) from breast cancer in a bone marrow aspirate of a subject. The invention further provides methods of treating breast cancer in the subject.Type: ApplicationFiled: June 8, 2018Publication date: May 28, 2020Inventors: Lewis Chodosh, Elizabeth Chislock
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Publication number: 20140234321Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the role of HUNK in tumor metastasis, primary tumor development, and the prediction of tumor behavior.Type: ApplicationFiled: February 7, 2014Publication date: August 21, 2014Applicant: The Trustees of The University of PennsylvaniaInventors: Lewis A. CHODOSH, Gerald Wertheim, Thomas W. Yang
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Publication number: 20120173160Abstract: Methods for quantitatively assessing the status of a biological event in a testing sample comprise computing a pair-wise energy score for each analyte pair for the biological event based on a testing magnitude value and a relative correlation value for the analyte pair, computing an energy-paired score for the biological event in the testing sample by combining the pair-wise energy score for each analyte pair, and optionally computing a significance level of the energy-paired score. Systems to implement such methods comprise computer readable medium, processors, or hardware to carry out these steps. The energy-paired score provides an estimation of how likely the biological event in the testing sample is up-regulated or down-regulated, which could aid in therapy, drug discovery, prognostic evaluation, or characterization of diseases.Type: ApplicationFiled: September 20, 2011Publication date: July 5, 2012Applicant: The Trustees of the University of PennsylvaniaInventors: Lewis Chodosh, Zhandong Liu, Tien-Chi Pan
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Patent number: 8029989Abstract: Provided is a prognostic molecular marker for breast cancer recurrence. Expression of Snail, a zinc finger transcriptional repressor gene, is correlated to the risk of breast cancer recurrence, and to the likelihood of recurrence-free survival in subjects diagnosed with breast cancer. Further provided are methods of identifying therapeutic compositions for treating breast cancer to reduce recurrence associated with high expression of Snail, and methods of controlling Snail expression for research and therapeutic purposes.Type: GrantFiled: August 25, 2006Date of Patent: October 4, 2011Assignee: The Trustees of the University of PennsylvaniaInventor: Lewis A. Chodosh
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Patent number: 7741111Abstract: This invention relates generally to a novel CaM multi-functional protein kinase, which has been named Pregnancy Up-Regulated, Nonubiquitous CaM Kinase (PNCK), and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; as well as to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo that are based upon that correlation.Type: GrantFiled: March 13, 2006Date of Patent: June 22, 2010Assignee: The Trustees of the University of PennsylvaniaInventors: Lewis A. Chodosh, Heather P. Gardner
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Publication number: 20090232819Abstract: Provided is a prognostic molecular marker for breast cancer recurrence. Expression of Snail, a zinc finger transcriptional repressor gene, is correlated to the risk of breast cancer recurrence, and to the likelihood of recurrence-free survival in subjects diagnosed with breast cancer. Further provided are methods of identifying therapeutic compositions for treating breast cancer to reduce recurrence associated with high expression of Snail, and methods of controlling Snail expression for research and therapeutic purposes.Type: ApplicationFiled: August 25, 2006Publication date: September 17, 2009Inventor: Lewis A. Chodosh
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Publication number: 20090170797Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the role of HUNK in tumor metastasis, primary tumor development, and the prediction of tumor behavior.Type: ApplicationFiled: September 22, 2005Publication date: July 2, 2009Inventors: Lewis A. Chodosh, Gerald Wertheim, Thomas W. Yang
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Publication number: 20090098100Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo, that are based upon that correlation; and to the regulation of pregnancy-induced changes in the mammary tissue that occur in response to estrogen and progesterone.Type: ApplicationFiled: April 7, 2008Publication date: April 16, 2009Inventors: Lewis A. Chodosh, Heather Gardner
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Patent number: 7368113Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo, that are based upon that correlation; and to the regulation of pregnancy-induced changes in the mammary tissue that occur in response to estrogen and progesterone.Type: GrantFiled: May 4, 2005Date of Patent: May 6, 2008Assignee: The Trustees of the University of PennsylvaniaInventors: Lewis A. Chodosh, Heather Gardner
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Publication number: 20070259419Abstract: This invention relates generally to a novel CaM multi-functional protein kinase, which has been named Pregnancy Up-Regulated, Nonubiquitous CaM Kinase (PNCK), and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; as well as to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo that are based upon that correlation.Type: ApplicationFiled: March 13, 2006Publication date: November 8, 2007Applicant: The Trustees of the University of PennsylvaniaInventors: Lewis Chodosh, Heather Gardner
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Patent number: 7119185Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo, that are based upon that correlation; and to the regulation of pregnancy-induced changes in the mammary tissue that occur in response to estrogen and progesterone.Type: GrantFiled: December 21, 2001Date of Patent: October 10, 2006Assignee: Trustees of the University of PennsylvaniaInventors: Lewis A. Chodosh, Heather P. Gardner
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Patent number: 7041495Abstract: This invention relates generally to a novel CaM multi-functional protein kinase, which has been named Pregnancy Up-Regulated, Nonubiquitous CaM Kinase (PNCK), and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; as well as to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo that are based upon that correlation.Type: GrantFiled: December 21, 2001Date of Patent: May 9, 2006Assignee: The Trustees of the University of PennsylvaniaInventors: Lewis A. Chodosh, Heather P. Gardner
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Publication number: 20050265985Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo, that are based upon that correlation; and to the regulation of pregnancy-induced changes in the mammary tissue that occur in response to estrogen and progesterone.Type: ApplicationFiled: May 4, 2005Publication date: December 1, 2005Inventors: Lewis Chodosh, Heather Gardner
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Publication number: 20050186668Abstract: This invention relates generally to a novel serine/threonine protein kinase, specifically to hormonally up-regulated, neu-tumor-associated kinase (HUNK); and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo, that are based upon that correlation; and to the regulation of pregnancy-induced changes in the mammary tissue that occur in response to estrogen and progesterone.Type: ApplicationFiled: December 21, 2001Publication date: August 25, 2005Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Lewis Chodosh, Heather Gardner
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Publication number: 20050186667Abstract: This invention relates generally to a novel CaM multi-functional protein kinase, which has been named Pregnancy Up-Regulated, Nonubiquitous CaM Kinase (PNCK), and to the nucleotide sequence encoding it. The kinase is temporally expressed during postnatal mammary development in a spatially heterogeneous manner in certain subsets of cells, and overexpressed in a subset of primary breast cancers. The invention further relates to an analysis of a correlation between carcinogenesis and postnatal development, particularly mammary development, especially associated with parity; as well as to methods of using the kinase, or gene encoding it, as markers, prognostic tools, screening tools and therapies, in vitro and in vivo that are based upon that correlation.Type: ApplicationFiled: December 21, 2001Publication date: August 25, 2005Applicant: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAInventors: Lewis Chodosh, Heather Gardner