Abstract: Disclosed herein are compounds and compositions useful in the treatment of GLS1 mediated diseases, such as cancer, having the structure of Formula I: Methods of inhibition GLS1 activity in a human or animal subject are also provided.

Abstract: A radioactivity dose calibrator system measures the quantity of radioactive material contained in a sample-vial or syringe without removing the vial or syringe from its primary radiation shield. The system comprises a first radiation detector, a second radiation detector, a transportable, shielded radioactive material sample-holder, a signal-processing circuit and a video display.

Abstract: A radioactivity dose calibrator system measures the quantity of radioactive material contained in a sample-vial or syringe without removing the vial or syringe from its primary radiation shield. The system comprises a first radiation detector, a second radiation detector, a transportable, shielded radioactive material sample-holder, a signal-processing circuit and a video display.

Abstract: A capacitive transducer which converts impulses of absorbed energy into impulses of electronic charge, combined with a unity-gain, non-inverting amplifier and an integrating capacitor which is substantially smaller than the transducer capacitance, further combined with a transconductance amplifier, comprises a simple and compact radiation detector probe. The detector probe, connected to a signal-receiving assembly through a shielded cable, comprises a useful apparatus for detecting and amplifying weak impulses of energy absorbed from X-ray photons, gamma-ray photons, or nuclear charged particles.

Abstract: A cyclotron and associated magnet coil and coil fabricating process. The cyclotron (10) includes a return yoke (12) defining a cavity (28) therein. A plurality of wedge-shaped regions called "hills" (29) are disposed in the return yoke (12), and voids called "valleys" (34) are defined between the hills (29). A single, substantially circular magnet coil (40) surrounds and axially spans the hills (29) and the valleys (34). The cyclotron magnet coil fabricating process includes the steps of securing a first end portion of a continuous length of sheet conductor to a substantially circular base, and positioning a first end portion of a length of insulator material coated on opposite sides with a thermosetting resin between the first end portion of the sheet conductor and the base.