Abstract: Embodiments provided herein, provide for variant IgG Fc polypeptides, dimeric molecules, pharmaceutical compositions, and methods that can be used to target at cells to modulate the activity of the same to treat disorders, such as autoimmune disorders or cancers.

Abstract: Embodiments of the presently-disclosed subject matter include methods and systems for measuring a level of a neurotransmitter in a subject. Embodiments of the present methods comprise displaying a fixation point, a reward target, and a non-reward target, and measuring one or more saccade movement parameters for reward saccades and non-reward saccades. The saccade movement parameters can include velocity, amplitude, reaction time, or a combination thereof. The present methods can further include determining a reward modulation of the subject, the reward modulation being equal to a difference between the reward and the non-reward values for a respective saccade movement parameter. Some embodiments further include identifying the subject as including a deficiency of the neurotransmitter if there is a statistically measurable difference between the reward modulation of the subject and a reference reward modulation and/or if the non-reward and the reward saccade movement parameters are statistically equivalent.

Abstract: Techniques are described herein for optimizing communications in a network. At a router in a virtual private network, a packet is received from a device in a subnetwork protected by the router. The router examines the packet to determine a source address that identifies the device and a destination address that identifies a destination network device for the packet. The router also analyzes the packet to determine a size of the packet and determines whether or not the size of the packet is larger than a maximum transmission unit size. If the size of the packet is larger than the maximum transmission unit size, the router encapsulates the packet with a header that includes the destination address and a new source address that identifies the router.

Abstract: Techniques are presented for optimizing secure communications in a network. As disclosed herein, a key server is configured to provision a plurality of routers that are part of a virtual private network. The key server selects a counter value that is part of a security association and calculates a key value. The key server sends the key value, together with the security association, to the plurality of routers that are part of the virtual private network to enable them to exchange encrypted packets with each other in the virtual private network using the key value and the security association. The key server then increments the counter value to a value within a range of counter values capable of being predicted by the plurality of routers that received the key value.

Abstract: Techniques are presented herein for optimizing secure communications in a network. A router in a virtual private network determines whether or not it has successfully registered with a key server that provides cryptographic keys for routers in the virtual private network. The router stores state information that is indicative of whether or not the router has successfully registered with the key server.

Abstract: Techniques are described herein for optimizing communications in a network. At a router in a virtual private network, a packet is received from a device in a subnetwork protected by the router. The router examines the packet to determine a source address that identifies the device and a destination address that identifies a destination network device for the packet. The router also analyzes the packet to determine a size of the packet and determines whether or not the size of the packet is larger than a maximum transmission unit size. If the size of the packet is larger than the maximum transmission unit size, the router encapsulates the packet with a header that includes the destination address and a new source address that identifies the router.

Abstract: Techniques are presented for optimizing secure communications in a network. As disclosed herein, a key server is configured to provision a plurality of routers that are part of a virtual private network. The key server selects a counter value that is part of a security association and calculates a key value. The key server sends the key value, together with the security association, to the plurality of routers that are part of the virtual private network to enable them to exchange encrypted packets with each other in the virtual private network using the key value and the security association. The key server then increments the counter value to a value within a range of counter values capable of being predicted by the plurality of routers that received the key value.

Abstract: Techniques are described herein for optimizing communications in a network. At a router in a virtual private network, a packet is received from a device in a subnetwork protected by the router. The router examines the packet to determine a source address that identifies the device and a destination address that identifies a destination network device for the packet. The router also analyzes the packet to determine a size of the packet and determines whether or not the size of the packet is larger than a maximum transmission unit size. If the size of the packet is larger than the maximum transmission unit size, the router encapsulates the packet with a header that includes the destination address and a new source address that identifies the router.

Abstract: Techniques are presented for optimizing secure communications in a network. A first router receives from a second router an encrypted packet with an unknown security association. The first router examines the packet to determine whether the counter value is in a range of predicted counter values. Additionally, a key server is configured to provision routers that are part of a virtual private network. The key server selects a counter value that is part of a security association and calculates a key value. The key server sends the key value together with the security association to enable routers to exchange encrypted packets with each other in the virtual private network using the key value and the security association. The key server increments the counter value to a value within a range of counter values capable of being predicted by the routers.

Abstract: Techniques are presented herein for optimizing secure communications in a network. A router in a virtual private network determines whether or not it has successfully registered with a key server that provides cryptographic keys for routers in the virtual private network. The router stores state information that is indicative of whether or not the router has successfully registered with the key server.

Abstract: Techniques are presented herein for optimizing secure communications in a network. A router in a virtual private network determines whether or not it has successfully registered with a key server that provides cryptographic keys for routers in the virtual private network. The router stores state information that is indicative of whether or not the router has successfully registered with the key server.

Abstract: Techniques are presented for optimizing secure communications in a network. A first router receives from a second router an encrypted packet with an unknown security association. The first router examines the packet to determine whether the counter value is in a range of predicted counter values. Additionally, a key server is configured to provision routers that are part of a virtual private network. The key server selects a counter value that is part of a security association and calculates a key value. The key server sends the key value together with the security association to enable routers to exchange encrypted packets with each other in the virtual private network using the key value and the security association. The key server increments the counter value to a value within a range of counter values capable of being predicted by the routers.

Abstract: Techniques are presented herein for optimizing secure communications in a network. A router in a virtual private network determines whether or not it has successfully registered with a key server that provides cryptographic keys for routers in the virtual private network. The router stores state information that is indicative of whether or not the router has successfully registered with the key server.

Abstract: Techniques are described herein for optimizing communications in a network. At a router in a virtual private network, a packet is received from a device in a subnetwork protected by the router. The router examines the packet to determine a source address that identifies the device and a destination address that identifies a destination network device for the packet. The router also analyzes the packet to determine a size of the packet and determines whether or not the size of the packet is larger than a maximum transmission unit size. If the size of the packet is larger than the maximum transmission unit size, the router encapsulates the packet with a header that includes the destination address and a new source address that identifies the router.

Abstract: Embodiments of the presently-disclosed subject matter include methods and systems for measuring a level of a neurotransmitter in a subject. Embodiments of the present methods comprise displaying a fixation point, a reward target, and a non-reward target, and measuring one or more saccade movement parameters for reward saccades and non-reward saccades. The saccade movement parameters can include velocity, amplitude, reaction time, or a combination thereof. The present methods can further include determining a reward modulation of the subject, the reward modulation being equal to a difference between the reward and the non-reward values for a respective saccade movement parameter. Some embodiments further include identifying the subject as including a deficiency of the neurotransmitter if there is a statistically measurable difference between the reward modulation of the subject and a reference reward modulation and/or if the non-reward and the reward saccade movement parameters are statistically equivalent.