Patents by Inventor Lewis H. Lambert, Jr.

Lewis H. Lambert, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products
    Patent number: 6849598
    Abstract: Improved therapeutic compositions having enhanced anti-microbial activity comprising a bactericidal/permeability-increasing (BPI) protein product and an bactericidal-activity enhancing polyoxyethylene block copolymer surfactant (poloxamer) surfactant or a bacterial and fungal growth-inhibiting enhancing poloaxamer surfactant, optionally with EDTA, and methods for treating bacterial infection by administering such compositions, alone or concurrently with antibiotics.
    Type: Grant
    Filed: October 24, 2000
    Date of Patent: February 1, 2005
    Assignee: XOMA
    Inventor: Lewis H. Lambert, Jr.
  • Treatment of Mycobacterial diseases by administration of bactericidal/permeability-increasing protein products
    Patent number: 6620785
    Abstract: The present invention relates to methods for treating a subject suffering from infection with Mycobacteria, such as M. leprae or M. tuberculosis comprising administering to the subject a composition comprising a bactericidal/permeability-inducing (BPI) protein product alone or in combination with administration of an anti-Mycobacterial antibiotic.
    Type: Grant
    Filed: February 13, 2001
    Date of Patent: September 16, 2003
    Assignee: Xoma Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Anti-chlamydial methods and materials
    Patent number: 6583116
    Abstract: The present invention relates to methods for treating chlamydial infection comprising administering to a subject suffering from a chlamydial infection a bactericidal permeability-inducing (BPI) protein product.
    Type: Grant
    Filed: October 30, 2000
    Date of Patent: June 24, 2003
    Assignee: Xoma Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Anti-protozoan methods and materials
    Patent number: 6440936
    Abstract: The present invention relates to methods for treating protozoan infections comprising administering to a subject suffering from protozoan infection, a bacteriocidal/permeability-inducing (BPI) protein product.
    Type: Grant
    Filed: June 8, 2001
    Date of Patent: August 27, 2002
    Assignee: Xoma Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Anti-protozoan methods and materials
    Patent number: 6271203
    Abstract: The present invention relates to methods for treating protozoan infections comprising administering to a subject suffering from protozoan infection, a bacteriocidal/permeability-inducing (BPI) protein product.
    Type: Grant
    Filed: October 12, 1999
    Date of Patent: August 7, 2001
    Assignee: Xoma Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Treatment of mycobacterial diseases by administration of bactericidal/permeability-increasing protein products
    Patent number: 6214789
    Abstract: The present invention relates to methods for treating a subject suffering from infection with Mycobacteria, such as M. leprae or M. tuberculosis comprising administering to the subject a composition comprising a bactericidal/permeability-inducing (BPI) protein product alone or in combination with administration of an anti-Mycobacterial antibiotic.
    Type: Grant
    Filed: April 1, 1996
    Date of Patent: April 10, 2001
    Assignee: Xoma Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Uses of BPI protein products
    Patent number: 6162788
    Abstract: The present invention relates to methods for treating chlamydial infection comprising administering to a subject suffering from a chlamydial infection a bactericidal/permeability-inducing (BPI) protein product.
    Type: Grant
    Filed: March 29, 1999
    Date of Patent: December 19, 2000
    Assignee: Xoma Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
    Patent number: 6140306
    Abstract: The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bacterial infections improves the therapeutic effectiveness of the antibiotic, including increasing antibiotic susceptibility of gram-negative bacteria and reversing resistance of the bacteria to antibiotics.
    Type: Grant
    Filed: June 3, 1996
    Date of Patent: October 31, 2000
    Assignee: Xoma Corporation
    Inventors: Lewis H. Lambert, Jr., Roger G. Little, II
  • Anti-gram-positive bacterial methods and materials
    Patent number: 6054431
    Abstract: The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.
    Type: Grant
    Filed: July 20, 1998
    Date of Patent: April 25, 2000
    Assignee: XOMA Corporation
    Inventors: Arnold Horwitz, Lewis H. Lambert, Jr., Roger G. Little, II
  • Anti-protozoan methods and materials
    Patent number: 6013629
    Abstract: The present invention relates to methods for treating protozoan infections comprising administering to a subject suffering from protozoan infection, a bacteriocidal/permeability-inducing (BPI) protein product.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: January 11, 2000
    Assignee: XOMA Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Therapeutic compositions comprising bactericidal/permeability-increasing (BPI) protein products
    Patent number: 5912228
    Abstract: Improved therapeutic compositions having enhanced anti-microbial activity comprising a bactericidal/permeability-increasing (BPI) protein product and an bactericidal-activity enhancing polyoxyethylene block copolymer surfactant (poloxamer) surfactant or a bacterial and fungal growth-inhibiting enhancing poloxamer surfactant, optionally with EDTA, and methods for treating bacterial infection by administering such compositions, alone or concurrently with antibiotics.
    Type: Grant
    Filed: January 12, 1996
    Date of Patent: June 15, 1999
    Assignee: XOMA Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Anti-chlamydial uses of BPI protein products
    Patent number: 5888973
    Abstract: The present invention relates to methods for treating chlamydial infection comprising administering to a subject suffering from a chlamydial infection a bactericidal/permeability-inducing (BPI) protein product.
    Type: Grant
    Filed: August 9, 1996
    Date of Patent: March 30, 1999
    Assignee: XOMA Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Anti-gram-positive bacterial methods and materials
    Patent number: 5783561
    Abstract: The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.
    Type: Grant
    Filed: November 25, 1996
    Date of Patent: July 21, 1998
    Assignee: XOMA Corporation
    Inventors: Arnold Horwitz, Lewis H. Lambert, Jr., Roger G. Little, II
  • Anti-protozoan methods
    Patent number: 5646114
    Abstract: The present invention relates to methods for treating protozoan infections comprising administering to a subject suffering from protozoan infection, a bacteriocidal/permeability-inducing (BPI) protein product.
    Type: Grant
    Filed: July 11, 1994
    Date of Patent: July 8, 1997
    Assignee: XOMA Corporation
    Inventor: Lewis H. Lambert, Jr.
  • Anti-gram-positive bacterial methods and materials
    Patent number: 5578572
    Abstract: The present invention relates to methods of treating gram-positive bacterial infections by administration of a BPI protein product alone, or in combination with an antibiotic. BPI protein product alone has a bactericidal or growth inhibitory effect on selected gram-positive organisms. BPI protein product also increases the susceptibility of gram-positive organisms to antibiotics and can even reverse resistance of gram-positive organisms to antibiotic.
    Type: Grant
    Filed: January 13, 1995
    Date of Patent: November 26, 1996
    Assignee: Xoma Corporation
    Inventors: Arnold Horwitz, Lewis H. Lambert, Jr., Roger G. Little, II
  • Method of treating gram-negative bacterial infection by administration of bactericidal/permeability-increasing (BPI) protein product and antibiotic
    Patent number: 5523288
    Abstract: The present invention relates to methods and compositions for treating gram-negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bacterial infections improves the therapeutic effectiveness of the antibiotic, including increasing antibiotic susceptibility of gram-negative bacteria and reversing resistance of the bacteria to antibiotics.
    Type: Grant
    Filed: September 22, 1994
    Date of Patent: June 4, 1996
    Assignee: Xoma Corporation
    Inventors: Jonathan Cohen, Ada H. C. Kung, Lewis H. Lambert, Jr., Roger G. Little, II