Patents by Inventor Lewis Makings

Lewis Makings has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optical molecular sensors for cytochrome P450 activity
    Patent number: 8153828
    Abstract: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods. The optical probe of the invention is a compound having the generic structure Y-L-Q, wherein Q is a chemical moiety that gives rise to optical properties in its hydroxy or hyrdoxylate, phenol or phenoxide form that are different from the optical properties that arise from its ether form.
    Type: Grant
    Filed: July 7, 2009
    Date of Patent: April 10, 2012
    Assignee: Life Technologies Corporation
    Inventors: Lewis Makings, Gregor Zlokarnik
  • Modulators of muscarinic receptors
    Patent number: 7820817
    Abstract: The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.
    Type: Grant
    Filed: May 31, 2005
    Date of Patent: October 26, 2010
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis Makings, Dennis Hurley, Miguel Gracia-Guzman Blanco, Daniele Bergeron, Akiko Nakatani
  • Modulators of Muscarinic Receptors
    Publication number: 20100105693
    Abstract: The present invention relates to substituted piperazine compounds that are useful modulators of muscarinic receptors. The present invention also provides compositions comprising such compounds, and methods for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: January 5, 2010
    Publication date: April 29, 2010
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Lewis Makings, Dennis Hurley, Miguel Gracia-Guzman Blanco, Daniele Bergeron, Akiko Nakatani
  • Muscarinic modulators
    Publication number: 20080090826
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: March 28, 2006
    Publication date: April 17, 2008
    Inventors: Ioana Drutu, Miguel Blanco, Lewis Makings, Gabriel Raffai, Valentin Zunic
  • Modulators of muscarinic receptors
    Publication number: 20080015179
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: December 22, 2006
    Publication date: January 17, 2008
    Inventors: Lewis Makings, Miguel Blanco, Dennis Hurley, Ioana Drutu, Gabriel Raffai, Daniele Bergeron, Akiko Nakatani, Andreas Termin, Alina Silina
  • OPTICAL MOLECULAR SENSORS FOR CYTOCHROME P450 ACTIVITY
    Publication number: 20070072256
    Abstract: The invention provides a compound, useful as an optical probe or sensor of the activity of at least one cytochrome P450 enzyme, and methods of using the compound to screen candidate drugs, and candidate drugs identified by these methods.
    Type: Application
    Filed: September 12, 2006
    Publication date: March 29, 2007
    Inventors: Lewis MAKINGS, Gregor ZLOKARNIK
  • Muscarinic modulators
    Publication number: 20070054911
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: March 28, 2006
    Publication date: March 8, 2007
    Inventors: Ioana Drutu, Miguel Blanco, Lewis Makings, Gabriel Raffai, Valentin Zunic
  • Modulators of muscarinic receptors
    Publication number: 20070043023
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: February 22, 2006
    Publication date: February 22, 2007
    Inventors: Lewis Makings, Miguel Blanco, Dennis Hurley, Ioana Drutu, Gabriel Raffai, Daniele Bergeron, Akiko Nakatani, Andreas Termin, Alina Silina
  • Modulators of muscarinic receptors
    Publication number: 20060287303
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: November 29, 2005
    Publication date: December 21, 2006
    Inventors: Dennis Hurley, Daniele Bergeron, Ioana Drutu, Miguel Blanco, Lewis Makings, Akiko Nakatani, Gabriel Raffai, Alina Silina
  • Modulators of muscarinic receptors
    Publication number: 20060270653
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: November 29, 2005
    Publication date: November 30, 2006
    Inventors: Ioana Drutu, Dennis Hurley, Upul Bandarage, Daniele Bergeron, Paul Charifson, Robert Davies, Miguel Blanco, Lewis Makings, Akiko Nakatani, Gabriel Raffai
  • Modulators of muscarinic receptors
    Publication number: 20060079505
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: August 19, 2005
    Publication date: April 13, 2006
    Applicant: VERTEX PHARMACEUTICALS, INCORPORATED
    Inventors: Lewis Makings, Miguel Blanco, Dennis Hurley, Ioana Drutu, Gabriel Raffai, Daniele Bergeron, Akiko Nakatani, Andreas Termin, Alina Silina
  • Modulators of muscarinic receptors
    Publication number: 20060019962
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: May 31, 2005
    Publication date: January 26, 2006
    Inventors: Lewis Makings, Dennis Hurley, Miguel Blanco, Daniele Bergeron, Akiko Nakatani
  • Modulators of ATP-Binding Cassette transporters
    Publication number: 20050176789
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including CF Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: September 7, 2004
    Publication date: August 11, 2005
    Inventors: Sara Hadida Ruah, Mark Miller, Ashvani Singh, Thomas Cleveland, Lewis Makings, Matthew Hamilton, Peter Grootenhuis
  • Modulators of muscarinic receptors
    Publication number: 20050171141
    Abstract: The modulator compounds described herein modulate muscarinic receptors and are useful for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: December 7, 2004
    Publication date: August 4, 2005
    Inventors: Peter Grootenhuis, Miguel Garcia-Guzman Blanco, Lewis Makings, Philip Martin Londo
  • Phenyl-piperazine derivatives as modulators of muscarinic receptors
    Publication number: 20050137211
    Abstract: The present invention relates to modulators of muscarinic receptors. The present invention also provides compositions comprising such modulators, and methods therewith for treating muscarinic receptor mediated diseases.
    Type: Application
    Filed: September 27, 2004
    Publication date: June 23, 2005
    Inventors: Miguel Blanco, Daniele Bergeron, Peter Grootenhuis, Dennis Hurley, Akiko Nakatani, Lewis Makings, Daniel DiSepio, Gabriel Raffai
  • Modulators of ATP-binding cassette transporters
    Publication number: 20050113423
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: March 12, 2004
    Publication date: May 26, 2005
    Inventors: Frederick VanGoor, Sara Ruah, Ashvani Singh, Eric Olson, Lewis Makings, Jesus Gonzalez, James Rader, Fred Chambers, Mark Miller, Peter Grootenhuis, Yahua Liu
  • Compounds useful as promoters of SMN2
    Publication number: 20050065173
    Abstract: The present invention relates to compounds useful as promoters of the SMN2 gene. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of Spinal Muscular Atrophy.
    Type: Application
    Filed: June 16, 2004
    Publication date: March 24, 2005
    Inventors: Jill Jarecki, Xiaocun Chen, Dennis Hurley, Lewis Makings, Mark Miller, Brian Pollok, Jeffrey Stack, Michael Whitney
  • Modulators of ATP-Binding Cassette transporters
    Publication number: 20050059687
    Abstract: The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator (“CFTR”), compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.
    Type: Application
    Filed: June 7, 2004
    Publication date: March 17, 2005
    Inventors: Lewis Makings, Ashavini Singh, Mark Miller, Sarah Ruah, Peter Grootenhuis, Matthew Hamilton, Anna Hazlewood, Liming Huang
  • Modulators of VR1 receptor
    Publication number: 20050004133
    Abstract: The present invention relates to compounds useful as modulators of the vanilloid receptor, and also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
    Type: Application
    Filed: June 4, 2004
    Publication date: January 6, 2005
    Inventors: Lewis Makings, Peter Grootenhuis, Dennis Hurley, Roger Tung, Andreas Termin