Abstract: A cryogenic treatment system has a housing that includes a dispensing nozzle operably connected with a CO2 dispensing conduit that includes a valve for controlling the flow of CO2 therethrough. A connector fitting is adapted for operably connecting the CO2 dispensing conduit with the separate CO2 source, which is not mounted on the housing. A temperature sensor is operably mounted for monitoring the temperature of a treated area of the patient, and an accelerometer is operably mounted for monitoring movement of the housing. A computer controller is operably connected with the temperature sensor and the accelerometer for controlling the valve responsive to the temperature sensor and the accelerometer.