Patents by Inventor Lewis Reuben Canning

Lewis Reuben Canning has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Metal chelating compounds having an SNNN donor set
    Patent number: 6004531
    Abstract: Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have formula (a) and (b), where A, A'=--SZ or Y, B.dbd.O or S, Y.dbd. (c), Z.dbd.H or a thiol protecting group, m=2 or 3, n=2 or 3, q=0 or 1, R.dbd.H or unsubstituted or substituted hydrocarbon and pharmaceutically acceptable salts, provided that at least one CR.sub.2 group represents CO and forms, together with an adjacent N atom, a --CONR-- amide group.
    Type: Grant
    Filed: August 26, 1997
    Date of Patent: December 21, 1999
    Assignee: Nycomed Amersham plc
    Inventors: Colin Mill Archer, Gary Robert Bower, Harjit Kaur Gill, Anthony Leonard Mark Riley, Anthony Eamon Storey, Lewis Reuben Canning, David Vaughan Griffiths
  • Radiometal complexes that localise in hypoxic tissue
    Patent number: 5997843
    Abstract: Methods of imaging and radiotherapy of hypoxic tissues are provided using radiometal complexes not substituted by a hypoxia-localizing moiety.
    Type: Grant
    Filed: April 9, 1996
    Date of Patent: December 7, 1999
    Assignee: Amersham International PLC
    Inventors: Colin Mill Archer, James Frederick Burke, Lewis Reuben Canning, Barbara Edwards, Adam Charles King
  • Metal-oxime chelates for use as radiopharmaceutical agents
    Patent number: 5993774
    Abstract: Novel metal chelating compounds, and radiometal, e.g., technetium-99m complexes thereof. The compounds can be used to radiolabel small biologically active species with minimal effect on their biodistribution and activity. The compounds have formula (a) or (b): ##STR1## where Z is (CR.sub.2).sub.n or (CR).sub.n, n is 2 or 3, X is a ligand comprising S, N or O, each R is H or C1-C20 substituted or unsubstituted hydrocarbon group, provided that 1-3 CR.sub.2 groups represent a CO (amide) moiety, and provided that 1-3 R may each comprise a targeting group and/or a protein reactive functionality.
    Type: Grant
    Filed: May 9, 1995
    Date of Patent: November 30, 1999
    Assignee: Amersham International plc
    Inventors: Colin Mill Archer, Lewis Reuben Canning, Harjit Kaur Gill, Anthony Leonard Mark Riley
  • Thioether-containing metal chelating compounds
    Patent number: 5932707
    Abstract: Ligands for radiopharmaceutical use are capable of chelating radiometal species and of being bound to biological targeting molecules. The ligands have the formula (a) and (b), where A, A'=--SZ or Y, B=O or S, Y=(c), Z=H or a thiol protecting group, m=2 or 3, n=2 or 3, q=0 or 1, R=H or unsubstituted or substituted hydrocarbon and pharmaceutically acceptable salts, provided that at least one CR.sub.2 group represents CO and forms, together with an adjacent N atom; a --CONR-- amide group.
    Type: Grant
    Filed: July 7, 1997
    Date of Patent: August 3, 1999
    Assignee: Nycomed Amersham plc
    Inventors: Colin Mill Archer, Gary Robert Bower, Harjit Kaur Gill, Anthony Leonard Mark Riley, Anthony Eamon Storey, Lewis Reuben Canning, David Vaughan Griffiths