Patents by Inventor Lewis Whitehead

Lewis Whitehead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CTPS1 INHIBITORS AND USES THEREOF
    Publication number: 20230077316
    Abstract: The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of CPTS1, and the treatment of CPTS1-mediated disorders.
    Type: Application
    Filed: October 22, 2021
    Publication date: March 9, 2023
    Inventors: Kevin D. KREUTTER, Lewis Whitehead, Angela V. West, Steven K. Albanese, Andreas Verras, Shaughnessy Robinson, Neelu Kaila, Sebastien Campos, Kevin Demarco
  • SUBSTITUTED 1,3-PHENYL HETEROARYL DERIVATIVES AND THEIR USE IN THE TREATMENT OF DISEASE
    Publication number: 20220306617
    Abstract: The invention relates to heterocyclic compounds of the formula (I) in which all of the variables are as defined in the specification; capable of modulating the ctivity of TMEM16a. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including COPD, bronchiectasis, asthma, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, cystic fibrosis, primary ciliary dyskinesia, respiratory tract infections (acute and chronic; viral and bacterial), lung carcinoma.
    Type: Application
    Filed: August 24, 2020
    Publication date: September 29, 2022
    Inventors: Claire ADCOCK, Jake AXFORD, Ying HOU, Hyungchul KIM, Yiping SHEN, Nichola SMITH, Catherine Fooks SOLOVAY, Moo Je SUNG, Megan LIGHTFOOT, Alessandro MAZZACANI, Emily STANLEY, Lewis WHITEHEAD
  • MACROCYCLIC COMPOUNDS AND THEIR USE IN THE TREATMENT OF DISEASE
    Publication number: 20220071971
    Abstract: The invention relates to heterocyclic compounds of the formula (I), in which all of the variables are as defined in the specification; capable of modulating the activity of CFTR. The invention further provides a method for manufacturing compounds of the invention, and its therapeutic uses. The invention further provides methods to their preparation, to their medical use, in particular to their use in the treatment and management of diseases or disorders including Cystic fibrosis and related disorders.
    Type: Application
    Filed: December 18, 2019
    Publication date: March 10, 2022
    Inventors: Mihai Azimioara, Badry Bursulaya, Songchun Jiang, Casey Jacob Nelson MATHISON, Victor Ivanovich NIKULIN, Truc Ngoc NGUYEN, Barun OKRAM, Sejal PATEL, Dean Paul PHILLIPS, Lewis WHITEHEAD, Baogen WU, Shanshan YAN, Xuefeng ZHU
  • AMINOTHIAZOLES AND THEIR USES
    Publication number: 20170015704
    Abstract: The present application describes organic compounds of Formula (I) and pharmaceutical compositions thereof, and their use for the treatment, prevention and/or amelioration of diseases, particularly bacterial infections.
    Type: Application
    Filed: September 22, 2016
    Publication date: January 19, 2017
    Applicant: Novartis AG
    Inventors: Simon Bushell, Matthew J. Lamarche, Jennifer Leeds, Lewis Whitehead
  • Aminothiazoles and their uses
    Patent number: 9492496
    Abstract: The present application describes organic compounds of Formula (I) and pharmaceutical compositions thereof, and their use for the treatment, prevention and/or amelioration of diseases, particularly bacterial infections.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: November 15, 2016
    Assignee: Novartis AG
    Inventors: Simon Bushell, Matthew J. Lamarche, Jennifer Leeds, Lewis Whitehead
  • POLYCYCLIC HERG ACTIVATORS
    Publication number: 20160108025
    Abstract: The present invention provides a compound of formula I, in which R1, R2, X and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: December 30, 2015
    Publication date: April 21, 2016
    Inventors: Gregory Raymond Bebernitz, Emma Cody, Tajesh Patel, Ming Qian, Lewis Whitehead, Thomas Zabawa, Frederic Zecri
  • Polycyclic HERG activators
    Patent number: 9255093
    Abstract: The present invention provides a compound of formula I, in which R1, R2, X and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Grant
    Filed: April 16, 2015
    Date of Patent: February 9, 2016
    Assignee: NOVARTIS AG
    Inventors: Gregory Raymond Bebernitz, Emma Cody, Tajesh Patel, Ming Qian, Lewis Whitehead, Thomas Zabawa, Frederic Zecri
  • POLYCYCLIC HERG ACTIVATORS
    Publication number: 20150299181
    Abstract: The present invention provides a compound of formula I, in which R1, R2, X and R3 are defined in the Summary of the Invention, or a pharmaceutically acceptable salt thereof; a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
    Type: Application
    Filed: April 16, 2015
    Publication date: October 22, 2015
    Inventors: Gregory Raymond BEBERNITZ, Emma CODY, Tajesh PATEL, Ming QIAN, Lewis WHITEHEAD, Thomas ZABAWA, Frederic ZECRI
  • AMINOTHIAZOLES AND THEIR USES
    Publication number: 20140315790
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
    Type: Application
    Filed: April 17, 2013
    Publication date: October 23, 2014
    Inventors: Simon Bushell, Matthew J, LaMarche, Michael A. Patane, Lewis Whitehead
  • AMINOTHIAZOLES AND THEIR USES
    Publication number: 20140274878
    Abstract: The present application describes organic compounds of Formula (I) and pharmaceutical compositions thereof, and their use for the treatment, prevention and/or amelioration of diseases, particularly bacterial infections.
    Type: Application
    Filed: May 30, 2014
    Publication date: September 18, 2014
    Applicant: NOVARTIS AG
    Inventors: Simon Bushell, Matthew J. Lamarche, Jennifer Leeds, Lewis Whitehead
  • AMINIOTHIAZOLES AND THEIR USES
    Publication number: 20130231275
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
    Type: Application
    Filed: April 17, 2013
    Publication date: September 5, 2013
    Applicant: Novartis AG
    Inventors: Simon Bushell, Matthew J. Lamarche, Jennifer Leeds, Lewis Whitehead
  • Aminothiazoles and their uses
    Patent number: 8426356
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
    Type: Grant
    Filed: December 12, 2008
    Date of Patent: April 23, 2013
    Assignee: Novartis AG
    Inventors: Simon Bushell, Matthew J. LaMarche, Jennifer Leeds, Lewis Whitehead
  • 5-phenylthiazole derivatives and use as PI3 kinase inhibitors
    Patent number: 8129541
    Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Grant
    Filed: December 17, 2009
    Date of Patent: March 6, 2012
    Assignee: Novartis AG
    Inventors: Ian Bruce, Peter Finan, Catherine LeBlanc, Clive McCarthy, Lewis Whitehead, Nicola Press, Graham Charles Bloomfield, Judy Hayler, Louise Kirman, Mrinalini Sachin Oza, Lena Shukla
  • EFTU inhibitors or aminothiazoles and their uses
    Patent number: 7851439
    Abstract: Organic compounds that are useful for the treatment, prevention and/or amelioration of diseases are described.
    Type: Grant
    Filed: May 30, 2007
    Date of Patent: December 14, 2010
    Assignee: Novartis AG
    Inventors: Simon Bushell, Matthew LaMarche, Michael J. Patane, Lewis Whitehead
  • AMINOTHIAZOLES AND THEIR USES
    Publication number: 20100267757
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
    Type: Application
    Filed: July 1, 2010
    Publication date: October 21, 2010
    Inventors: Matthew J. LaMarche, Simon Bushell, Michael A. Patane, Lewis Whitehead
  • 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS
    Publication number: 20100093690
    Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Application
    Filed: December 17, 2009
    Publication date: April 15, 2010
    Inventors: Ian Bruce, Peter Finan, Catherine LeBlanc, Clive McCarthy, Lewis Whitehead, Nicola Press, Graham Charles Bloomfield, Judy Hayler, Louise Kirman, Mrinalini Sachin Oza, Lena Shukla
  • 5-phenylthiazole derivatives and use as Pi3 kinase inhibitors
    Patent number: 7687637
    Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Grant
    Filed: February 27, 2003
    Date of Patent: March 30, 2010
    Assignee: Novartis AG
    Inventors: Ian Bruce, Peter Finan, Catherine Leblanc, Clive McCarthy, Lewis Whitehead, Nicola Press, Graham Charles Bloomfield, Judy Hayler, Louise Kirman, Mrinalini Sachin Oza, Lena Shukla
  • Aminothiazoles and their Uses
    Publication number: 20090156628
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases particularly bacterial infections.
    Type: Application
    Filed: December 12, 2008
    Publication date: June 18, 2009
    Inventors: Simon Bushell, Matthew J. LaMarche, Jennifer Leeds, Lewis Whitehead
  • EFTU INHIBITORS OR AMINOTHIAZOLES AND THEIR USES
    Publication number: 20080221142
    Abstract: The present application describes organic compounds that are useful for the treatment, prevention and/or amelioration of diseases.
    Type: Application
    Filed: May 30, 2007
    Publication date: September 11, 2008
    Inventors: Matthew J. LaMarche, Simon Bushell, Michael A. Patane, Lewis Whitehead
  • 5-phenylthiazole derivatives and use as pi3 kinase inhibitors
    Publication number: 20050119320
    Abstract: Compounds of formula I in free or salt form, wherein R1, R2, R3, R4 and R5 have the meanings as indicated in the specification, are useful for treating diseases mediated by phosphatidylinositol 3-kinase. Pharmaceutical compositions that contain the compounds and processes for preparing the compounds are also described.
    Type: Application
    Filed: February 27, 2003
    Publication date: June 2, 2005
    Inventors: Ian Bruce, Peter Finan, Catherine Leblanc, Clive McCarthy, Lewis Whitehead, Nicola Press, Graham Bloomfield, Judy Hayler, Louise Kirman, Mrinalini Oza, Lena Shukla