Patents by Inventor Lex Cowsert

Lex Cowsert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20050101553
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of calreticulin. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding calreticulin. Methods of using these compounds for modulation of calreticulin expression and for treatment of diseases associated with expression of calreticulin are provided.
    Type: Application
    Filed: October 30, 2001
    Publication date: May 12, 2005
    Inventors: C. Bennett, Lex Cowsert
  • Publication number: 20050095710
    Abstract: Compounds, compositions and methods are provided for modulating the expression of PTP1B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTP1B. Methods of using these compounds for modulation of PTP1B expression and for treatment of diseases associated with expression of PTP1B are provided.
    Type: Application
    Filed: December 9, 2004
    Publication date: May 5, 2005
    Applicant: ISIS Pharmaceuticals, Inc.
    Inventors: Lex Cowsert, Jacqueline Wyatt, Susan Freier, Brett Monia, Madeline Butler, Robert McKay
  • Publication number: 20050074878
    Abstract: Antisense compounds, compositions and methods are provided for modulating the expression of PTPN2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding PTPN2. Methods of using these compounds for modulation of PTPN2 expression and for treatment of diseases associated with expression of PTPN2 are provided.
    Type: Application
    Filed: May 15, 2002
    Publication date: April 7, 2005
    Inventors: Lex Cowsert, Susan Freier
  • Publication number: 20050033524
    Abstract: Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is provided or selected, and a library of candidate nucleobase sequences is generated in silico according to defined criteria. A “virtual” oligonucleotide chemistry is chosen and a library of virtual oligonucleotide compounds having the selected nucleobase sequences is generated. These virtual compounds are reviewed and compounds predicted to have particular properties are selected. The selected compounds are robotically synthesized and are preferably robotically assayed for a desired physical, chemical or biological activity. Active compounds are thus generated and, at the same time, preferred sequences and regions of the target nucleic acid that are amenable to oligonucleotide or sequence-based modulation are identified.
    Type: Application
    Filed: August 27, 2003
    Publication date: February 10, 2005
    Inventors: Lex Cowsert, Brenda Baker, John McNeil, Susan Freier, Henri Sasmor, Douglas Brooks, Cara Ohashi, Jacqueline Wyatt, Alexander Borchers, Timothy Vickers