Patents by Inventor Leyi Gong

Leyi Gong has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Benzotriazole kinase modulators
    Publication number: 20080103142
    Abstract: Compounds of formula I modulate jnk and cdk: or a pharmaceutically acceptable salt thereof, where R, R1, R2, R3, and m are defined herein.
    Type: Application
    Filed: September 7, 2007
    Publication date: May 1, 2008
    Inventors: David Goldstein, Leyi Gong, Christophe Michoud, Wylie Palmer, Achyutharao Sidduri
  • Glucocorticoid receptor modulators as antiinflammatory agents
    Patent number: 7348322
    Abstract: The present invention relates to compounds of formula I: wherein A, X, R1, R2 and R3 are as defined herein and pharmaceutically acceptable salts thereof. The invention also relates to methods of using the compounds of formula I and pharmaceutical compositions comprising the compounds of formula I.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: March 25, 2008
    Assignee: Roche Palo Alto LLC
    Inventors: Leyi Gong, Counde O'Yang, Yun-chou Tan
  • Propionamide compounds as antiinflammatory agents
    Publication number: 20070135500
    Abstract: The present invention relates to compounds of formula I: wherein R1, R2 and R3 are as defined herein and pharmaceutically acceptable salts thereof The invention also relates to methods of using the compounds of formula I and pharmaceutical compositions comprising the compounds of formula I.
    Type: Application
    Filed: December 8, 2006
    Publication date: June 14, 2007
    Inventors: Leyi Gong, Counde O'Yang, Yun-chou Tan
  • Glucocorticoid receptor modulators as antiinflammatory agents
    Publication number: 20070135427
    Abstract: The present invention relates to compounds of formula I: wherein A, X, R1, R2 and R3 are as defined herein and pharmaceutically acceptable salts thereof. The invention also relates to methods of using the compounds of formula I and pharmaceutical compositions comprising the compounds of formula I.
    Type: Application
    Filed: December 8, 2006
    Publication date: June 14, 2007
    Inventors: Leyi Gong, Counde O'Yang, Yun-chou Tan
  • Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists
    Publication number: 20060194790
    Abstract: Compounds having the formula (I), Ar—F-(E)-(CR3R4)—(CHR5)m-(T)-(Q)-Ar1, are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridge of one to two bridgehead carbon atoms; Ar and Ar1 are aryl or heteroaryl; F is alkylene, alkenylene, or a bond; E is —C(?O)N(R10)—, —SO2N(R10)—, —N(R11)C(?O)N(R10O)—, —N(R11)SO2N(R10)—, —N(R11)C(?S)N(R10)—, —N(R11)C(?O)—, —N(R11)SO2—, —N(R12)C(?O)CH(R13)—, or CH(R13)C(?O)N(R12)—; Q is —C(?O)— or C1-2alkylene; and R3, R4, R5, R9, R10, R11, R12, and R13 are defined as set forth in the specification.
    Type: Application
    Filed: April 26, 2006
    Publication date: August 31, 2006
    Inventor: Leyi Gong
  • Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists
    Publication number: 20060189596
    Abstract: Compounds having the formula (1), are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridge of one to two bridgehead carbon atoms; Ar and Ar1 are aryl or heteroaryl; F is alkylene, alkenylene, or a bond; E is —C(?O)N(R10)—, —SO2N(R10)—, —N(R11)C(?O)N(R10)—, —N(R11)SO2N(R10)—, —N(R11)C(?S)N(R10)—, —N(R11)C(?O)—, —N(R11)SO2—, —N(R12)C(?O)CH(R13)—, or CH(R13)C(?O)N(R12)—; Q is —C(?O)— or C1-2alkylene; and R3, R4, R5, R9, R10, R11, R12, and R13 are defined as set forth in the specification.
    Type: Application
    Filed: April 26, 2006
    Publication date: August 24, 2006
    Inventor: Leyi Gong
  • Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists
    Patent number: 7081531
    Abstract: Compounds having the formula (I), Ar—(F)-(E)-(CR3R4)—(CHR5)m-(T)-(Q)-Ar1, are useful as CCR-3 receptor antagonists, wherein T is a bridged heterocyclyl group having one N atom and a bridge of one to two bridgehead carbon atoms; Ar and Ar1 are aryl or heteroaryl; F is alkylene, alkenylene, or a bond; E is —C(?O)N(R10)—, —SO2N(R10)—, —N(R11)C(?O)N(R10)—, —N(R11)SO2N(R10)—, —N(R11)C(?S)N(R10)—, —N(R11)C(?O)—, —N(R11)SO2—, —N(R12)C(?O)CH(R13)—, or CH(R13)C(?O)N(R12)—; Q is —C(?O)— or C1-2alkylene; and R3, R4, R5, R9, R10, R11, R12, and R13 are defined as set forth in the specification.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: July 25, 2006
    Assignee: Roche Palo Alto LLC
    Inventor: Leyi Gong
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6984637
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 21, 2003
    Date of Patent: January 10, 2006
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Piperidinyl and piperazinyl compounds substituted with bicyclo-heterocyclylalkyl groups useful as CCR3 receptor antagonists
    Publication number: 20050090504
    Abstract: Compounds having the Formula (I), are useful as CCR3 receptor antagonists, wherein Ar is aryl or heteroaryl; Q is —C(?O)— or C1-2alkylene; X is N(+)R9a, or N; Y is CR9b, or N; R2 is hydrogen or alkyl; R3 and R4 are as defined in the specification; Uc is a mono- or bicyclic group as defined in the specification; n is 0 or 1; and p is 0, 1, 2, 3 or 4.
    Type: Application
    Filed: October 25, 2004
    Publication date: April 28, 2005
    Inventors: Leyi Gong, Robert Wilhelm
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Publication number: 20040266782
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1
    Type: Application
    Filed: November 21, 2003
    Publication date: December 30, 2004
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Bridged bicyclic amine derivatives useful as CCR-3 receptor antagonists
    Publication number: 20040176416
    Abstract: Compounds having the formula (I),
    Type: Application
    Filed: February 26, 2004
    Publication date: September 9, 2004
    Inventor: Leyi Gong
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6770650
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 29, 2001
    Date of Patent: August 3, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Donald Roy Hirschfeld, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6683074
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: September 26, 2001
    Date of Patent: January 27, 2004
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Methods for increasing bone formation using inhibitors of glycogen synthase kinase-3 betta
    Publication number: 20030176484
    Abstract: This invention relates to the use of inhibitors of glycogen synthase kinase-3&bgr; to increase bone formation.
    Type: Application
    Filed: January 9, 2003
    Publication date: September 18, 2003
    Applicant: Syntex (U.S.A.) LLC
    Inventors: Patricia Ann Day-Lollini, Leyi Gong
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Publication number: 20030153577
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) 1
    Type: Application
    Filed: August 29, 2001
    Publication date: August 14, 2003
    Applicant: Roche Bioscience
    Inventors: Leyi Gong, Donald Roy Hirschfeld, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
    Publication number: 20020188018
    Abstract: This invention relates to inhibitors of glycogen synthase kinase-3&bgr;, methods of treating diseases characterized by an excess of Th2 cytokines, and to 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives of Formula (I): 1
    Type: Application
    Filed: May 6, 2002
    Publication date: December 12, 2002
    Inventors: Leyi Gong, Andrew Grupe, Gary Allen Peltz
  • 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3&bgr;
    Patent number: 6479490
    Abstract: This invention relates to inhibitors of glycogen synthase kinase-3&bgr;, methods of treating diseases characterized by an excess of Th2 cytokines, and to 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives of Formula (I): that are inhibitors of glycogen synthase kinase -3&bgr;, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: July 27, 2001
    Date of Patent: November 12, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Andrew Grupe, Gary Allen Peltz
  • 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives as inhibitors of glycogen synthase kinase-3beta
    Publication number: 20020052397
    Abstract: This invention relates to inhibitors of glycogen synthase kinase-3&bgr;, methods of treating diseases characterized by an excess of Th2 cytokines, and to 3-indolyl-4-phenyl-1H-pyrrole-2,5-dione derivatives of Formula (I): 1
    Type: Application
    Filed: July 27, 2001
    Publication date: May 2, 2002
    Inventors: Leyi Gong, Andrew Grupe, Gary Allen Peltz
  • Cyclic amine derivatives-CCR-3 receptor antagonists
    Patent number: 6339087
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonist, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: January 15, 2002
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm
  • Cyclic amine derivatives- CCR-3 receptor antagonists
    Patent number: 6323223
    Abstract: This invention relates to certain cyclic amine derivatives of Formula (I) that are CCR-3 receptor antagonists, pharmaceutical compositions containing them, methods for their use and methods for preparing these compounds.
    Type: Grant
    Filed: August 14, 1998
    Date of Patent: November 27, 2001
    Assignee: Syntex (U.S.A.) LLC
    Inventors: Leyi Gong, Denis John Kertesz, David Bernard Smith, Francisco Xavier Talamas, Robert Stephen Wilhelm