Abstract: Provided is an isolated antigen-binding protein, wherein the drug is used for the treatment of tumor, and the isolated antigen-binding protein comprises a PD-L1 binding moiety and an OX40 binding moiety, wherein: the OX40 binding moiety is capable of recognizing and/or binding amino acid residues G70 and/or F71 in a human OX40 extracellular domain; and the PD-L1 binding moiety is capable of recognizing and/or binding amino acid residues I54, Y56, E58, Q66 and/or R113 in an N-terminal IgV domain of human PD-L1. Further provided is a use of the isolated antigen-binding protein in preparing a drug, wherein the drug is used for the treatment of tumors.

Abstract: Devices, systems, and methods for palette mode coding are described. An exemplary method for video processing includes performing a conversion between a block of a video and a bitstream representation of the video. The bitstream representation is processed according to a format rule that specifies a first indication of usage of a palette mode and a second indication of usage of an intra block copy (IBC) mode are signaled dependent of each other.

Abstract: Techniques for video processing, including video coding, video decoding and video transcoding are described. One example method includes performing a conversion between a video picture that includes one or more tiles and one or more rectangular slices and a bitstream of the video according to a rule. The rule specifies that, for iteratively determining information about the one or more rectangular slices, a variable indicating a tile index is updated only for slices having indices that are smaller than a value equal to a number of slices in the video picture minus 1.

Abstract: A carrier structure is provided, in which at least one positioning area is defined on a chip-placement area of a package substrate, and at least one alignment portion is disposed on the positioning area. Therefore, the precision of manufacturing the alignment portion is improved by disposing the positioning area on the chip-placement area, such that the carrier structure can provide a better alignment mechanism for the chip placement operation.

Abstract: The present disclosure relates to a nitrogen-doped porous carbon material and a preparation method and use thereof. In the present disclosure, the preparation method of a nitrogen-doped porous carbon material includes the following steps: conducting carbonization on a biomass material to obtain a carbon source; and mixing the carbon source with a potassium 4-aminobenzoate aqueous solution, and drying and conducting calcination in a protective atmosphere sequentially to obtain the nitrogen-doped porous carbon material. In the preparation method, the potassium 4-aminobenzoate is used as a nitrogen source as well as an activator for preparing the nitrogen-doped porous carbon material. Nitrogen doping is simultaneously completed during the activation, and the nitrogen-doped porous carbon material can be prepared through one-step calcination.

Abstract: The present invention relates to the field of biomedicine, and in particular to a use of goji glycopeptide in the preparation of a drug for preventing and/or treating amyotrophic lateral sclerosis. Experimental results prove the use of goji glycopeptide in the preparation of a drug for preventing and/or treating amyotrophic lateral sclerosis.

Abstract: The present disclosure relates to compounds of Formula (1), which inhibit Gal-3, and include pharmaceutically acceptable salts, compositions comprising such compounds, and methods making and using such compounds and compositions.

Abstract: A method of video processing includes determining a refined prediction sample P?(x,y) at a position (x,y) in a video block by modifying a prediction sample P(x,y) at the position (x,y) with a first gradient component Gx(x, y) in a first direction estimated at the position (x,y) and a second gradient component Gy(x, y) in a second direction estimated at the position (x,y) and a first motion displacement Vx(x,y) estimated for the position (x,y) and a second motion displacement Vy(x,y) estimated for the position (x,y), where x and y are integer numbers, and performing a conversion between the video block and a bitstream representation of the video block using a reconstructed sample value Rec(x,y) at the position (x,y) that is obtained based on the refined prediction sample P?(x,y) and a residue sample value Res(x,y).

Abstract: An example method of video processing includes determining, for a conversion between a block of a chroma component of a video and a bitstream representation of the video, whether or how to apply a filtering process to an edge of the block based on a first quantization information for a first video region comprising samples on one side of the edge and/or a second quantization information for a second video region comprising samples on the other side of the edge according to a rule that is based on a coding mode applicable to the block for coding the samples on the one side or the samples on the other side of the edge. The rule specifies that multiple QP offsets at different video unit levels are used to determine the first quantization information or the second quantization information. The method also includes performing the conversion based on the determining.

Abstract: A method of video processing is described. The method includes: deriving, for a conversion between a current block of a video and a coded representation of the video, a prediction block for the current block that is determined according to a tool in which weights are used to determine a weighted sum of two initial prediction blocks used to determine the prediction block; and performing the conversion using the prediction block; wherein the deriving includes: applying the weights to two intermediate prediction samples that respectively belong to the two initial prediction blocks to derive a final prediction sample; and performing a right shift operation for the final prediction sample, wherein the right shift operation is pbSample>> (shift1+3)), wherein pbSample represents the final prediction sample, shift1 is set equal to Max(2, 14?bitDepth); and determining the prediction block based on the final prediction sample.

Abstract: An underwater sonar device and an underwater detecting system. The underwater sonar device comprises a main body, a propeller, a detector and a hydrofoil assembly. The main body is an axisymmetric structure. The propeller, the detector, and the hydrofoil assembly are disposed on the main body. The detector is configured to detect and image an underwater target. The propeller is configured to drive the main body to move along a longitudinal direction and a vertical direction, and control a pitch angle, a roll angle, and a yaw angle of the main body. The hydrofoil assembly is disposed at a back of the main body, and is configured to adjust an included angle between the hydrofoil assembly and the longitudinal direction of the main body automatically based on water resistance on the hydrofoil assembly to keep the sonar device navigating at a fixed depth.

Abstract: A method for processing a video includes performing a conversion between a current block of visual media data and a corresponding coded representation of the visual media data. The conversion of the current block includes determining whether a use of one or both of a bi-directional optical flow (BIO) technique or a decoder-side motion vector refinement (DMVR) technique to the current block is enabled or disabled. Determining the use of the BIO technique or the DMVR technique is based on a cost criterion associated with the current block.

Abstract: A riding mowing device includes a seat used for a user to sit on and including a seat cushion and a backrest; a frame for supporting the seat; a cutting assembly including a cutting deck and a mowing element for mowing grass, where the mowing element is at least partially accommodated in the cutting deck, and the cutting assembly is mounted to the frame; a traveling assembly for driving the riding mowing device to travel; a control circuit board for controlling at least the cutting assembly and the traveling assembly; and a power supply assembly for supplying power to at least the cutting assembly and the traveling assembly. At least part of the control circuit board is disposed between the seat and the power supply assembly.

Abstract: Embodiments of the present disclosure provide a method for point cloud coding. The method comprises: obtaining, during a conversion between a current frame of a point cloud sequence and a bitstream of the point cloud sequence, a compensated reference frame of the current frame by performing motion compensation on a reference frame of the current frame based on a set of rotation matrixes comprising at least one fixed rotation matrix or a plurality of rotation matrixes; and performing the convention based on the compensated reference frame. Compared with the conventional solution, the proposed method can advantageously improve coding efficiency.

Abstract: Embodiments of the present disclosure provide a method for point cloud coding. The method comprises: classifying, during a conversion between a current frame of a point cloud sequence and a bitstream of the point cloud sequence, a target point in the current frame into a first set of classes based on a second set of thresholds, the number of thresholds in the second set being larger than the number of classes in the first set; and performing the conversion based on the classification. Compared with the conventional solution, the proposed method can advantageously improve the accuracy of global motion estimation and coding quality.

Abstract: The present disclosure provides an anti-tumor polypeptide Bax-BH3, a fluorescent polymeric nanomicelle, a preparation method and use thereof, belonging to the technical field of medicines. The anti-tumor polypeptide Bax-BH3 has an amino acid sequence set forth in SEQ ID No: 1; the fluorescent polymeric nanomicelle includes the anti-tumor polypeptide Bax-BH3 and a polymer carrier; and the polymer carrier is a block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)). In the present disclosure, the anti-tumor polypeptide Bax-BH3 has desirable biocompatibility and biological activity; and the fluorescent polymeric nanomicelle encapsulates the anti-tumor polypeptide Bax-BH3 by the block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)), with high encapsulation rate and drug loading, and good release performance.

Abstract: A method for automatic metadata tag identification for videos is described. Content features are extracted from a video into respective data structures. The extracted content features are from at least two different feature modalities. The respective data structures are encoded into a common data structure using an encoder of a recurrent neural network (RNN) model. The common data structure is decoded using a decoder of the RNN model to identify content platform metadata tags to be associated with the video on a social content platform. Decoding is based on group tag data for users of the social content platform that identifies groups of the users and corresponding group metadata tags of interest for the groups of users.

Abstract: This disclosure provides a method, a computing system, and a computer program product for managing prefetching of pages in a database system. The method comprises obtaining shared information associated with page access, wherein the shared information associated with the page access includes information associated with the page access from a plurality of computing nodes. The method further comprises determining whether to prefetch a number of pages into a global buffer pool based at least on the shared information associated with the page access using a sequential prefetching method.

Abstract: The invention relates generally to recombinant human sialidases and recombinant sialidase fusion proteins, wherein the sialidase optionally contains one or more mutations compared to wild-type human sialidase, e.g., a substitution, deletion, or addition of at least one amino acid. The invention also provides antibody conjugates including a sialidase and an antibody or a portion thereof. The invention further relates to methods of using the sialidase fusion proteins or antibody conjugates for treating cancer.

Abstract: A method of video processing includes performing a conversion between a current video block of a second color component of a video and a bitstream of the video using a cross-component prediction with multiple-parameter model (CCPMPM) in which samples of the current video block are predictively coded in the bitstream using a linear combination of samples of a first color component multiplied by linear coefficients and/or one or more offsets. The bitstream conforms to a format rule. The linear coefficients of the CCPMPM are determined using a first rule. The samples of the first color component are determined using a second rule.