Abstract: The present disclosure provides liver-specific Wnt signal enhancing molecules, and related methods of using these molecules to increase Wnt signaling in liver tissues and treat liver diseases and disorders.

Abstract: Methods and compositions for treatment of dry-eye disorders are provided. In particular, the present disclosure provides methods and compositions for modulating WNT (Wingless and lnt-1) signaling in a subject to modulate regeneration of tear-producing acinar cells to treat aqueous-deficient type dry-eye diseases. Further disclosed are WNT signaling modulators used in the methods.

Abstract: A method for forming a semiconductor structure is provided. The method includes forming a first nanostructure and a second nanostructure over a substrate, forming a first interfacial layer on the first nanostructure and a second interfacial layer on the second nanostructure, forming a first gate dielectric layer on the first interfacial layer and a second gate dielectric layer on the second interfacial layer, forming a patterned mask layer on the second gate dielectric layer while exposing the first gate dielectric layer, and driving nitrogen into the first interfacial layer, thereby forming a nitrogen-doped interfacial layer.

Abstract: A filling and covering machine for centrifuge tubes with tethered caps includes a conveying device, a cap-flapping device, a filling device, and a cap-pressing device. The cap-flapping device has an upper planar surface and a cap-guiding member having a starting end portion, an ending end portion that is opposite to the starting end portion, and a guiding surface extending from the starting end portion to the ending end portion, and cooperates with the upper planar surface to define an included angle therebetween decreasing gradually from the starting end portion to the ending end portion to guide a cap of each of the centrifuge tubes with tethered caps toward a tube body thereof.

Abstract: An electronic paper display includes a surface cover plate, a lighting module, a first optical adhesive layer, an electronic paper display module and a second optical adhesive layer. A peripheral area of a bottom surface thereof is provided with a black bezel formed by an opaque or low-light-transmittance material. The bottom surface is disposed with a low-refractive-index transparent resin layer. The lighting module has a light guide plate and multiple point light sources. The point light sources are disposed outside an outer edge of the light guide plate. The lighting module is disposed under the surface cover plate. The first optical adhesive layer glues the surface cover plate and the lighting module. The electronic paper display module is disposed under the lighting module. The second optical adhesive layer glues the lighting module and the light guide plate of the lighting module.

Abstract: A method for designing a multi-objective primer pair is disclosed. The method includes inputting a DNA template fragment, a length of a forward primer, a length of a reverse primer, at least two objectives and optimal values for each of the at least two objectives to a computer system; generating, by the computer system, a plurality of primer pairs according to the DNA template fragment, the length of the forward primer and the length of the reverse primer; and calculating, by the computer system, numerical values of the at least two objectives of each of the plurality of primer pairs and inputting the numerical values of the at least two objectives of each of the plurality of primer pairs to a Pareto Chart tool to obtain at least one primer pair, and taking the primer pair as an optimal solution of the DNA template fragment.

Abstract: A lighting structure includes a surface cover plate, a lighting module, a light adjustment layer, an optical adhesive layer and an electronic paper display module. The surface cover plate has a visible area and a black bezel. The lighting module has a light guide plate and point light sources. The light adjustment layer has an optical thinning region and a frame-shaped adhesive. The optical thinning region is less than the light guide plate in refractive index. The surface cover plate and the lighting module are adhered by the frame-shaped adhesive. The optical thinning region is disposed on an upper surface of the light guide plate. The optical adhesive layer has a refractive index equal to or greater than a refractive index of the light guide plate. The electronic paper display module is disposed under the lighting module.

Abstract: A method for designing a multi-objective primer pair is disclosed. The method includes inputting a DNA template fragment, a length of a forward primer, a length of a reverse primer, at least two objectives and optimal values for each of the at least two objectives to a computer system; generating, by the computer system, a plurality of primer pairs according to the DNA template fragment, the length of the forward primer and the length of the reverse primer; and calculating, by the computer system, numerical values of the at least two objectives of each of the plurality of primer pairs and inputting the numerical values of the at least two objectives of each of the plurality of primer pairs to a Pareto Chart tool to obtain at least one primer pair, and taking the primer pair as an optimal solution of the DNA template fragment.

Abstract: The invention discloses a test circuit, a test method and an audio codec for testing a microphone module that includes a first microphone and a second microphone. The first microphone outputs the first data, and the second microphone outputs the second data. The test circuit includes a comparison circuit, a counter, and a decision circuit. The comparison circuit is configured to compare the first data with the second data and generate a comparison result. The counter is coupled to the comparison circuit and configured to generate a count value based on the comparison result. The decision circuit is coupled to the counter and configured to indicate, based on the count value and a threshold value, whether the microphone module has an error.

Abstract: The invention provides a switch device including a shell, an operating member, a spring, a movable conductor, a first pin, a second pin, two resistors, and two connecting conductors. The operating member is partially exposed out of the shell, and the movable conductor is displaced when the operating member is operated. One side of the shell is provided with the first pin and the spring, another side is provided with the second pin. The resistors are connected with the second pin and have different resistance values. The connecting conductors are arranged between the two pins. The first pin contacts with the movable conductor. The connecting conductors without disposal of any crossover part therebetween and respectively connected with the resistors. The connecting conductors are arranged at intervals along a displacement path of the movable conductor which contacted one connecting conductor before and after displacement and forming two conductive paths.

Abstract: A protection structure includes a substrate, a signal wire pattern, a protective ring and micro-blocks. The substrate has a touch sensing pattern including sensing strings. The signal wire pattern has conductive wires. Each conductive wire electrically connects one of the sensing strings to a signal processor. The protective ring is formed at a peripheral zone of the substrate and around the touch sensing pattern. The micro-blocks are disposed in the protective ring and have electric conductivity. A gap is disposed between every adjacent two of the micro-blocks for insulation.

Abstract: The invention discloses a test circuit, a test method and an audio codec for testing a microphone module that includes a first microphone and a second microphone. The first microphone outputs the first data, and the second microphone outputs the second data. The test circuit includes a comparison circuit, a counter, and a decision circuit. The comparison circuit is configured to compare the first data with the second data and generate a comparison result. The counter is coupled to the comparison circuit and configured to generate a count value based on the comparison result. The decision circuit is coupled to the counter and configured to indicate, based on the count value and a threshold value, whether the microphone module has an error.

Abstract: This invention relates generally to compounds that are glucuronidase inhibitors. The glucuronidase inhibitors include phenoxy thiophene sulfonamides, and other compounds such as pyridine sulfonyls, benzene sulfonyls, thiophene sulfonyls, thiazole sulfonyls, thiophene carbonyls, and thiazole carbonyls. These compounds include nialamide, isocarboxazid, phenelzine, amoxapine, loxapine and mefloquine. Also compositions including one or more of such compounds for use in inhibiting glucuronidase and methods of using one or more of such compounds for selective inhibition of bacterial ?-glucoronidase. These compounds may be used as a co-drug in combination with the anticancer drug CPT-11. Also a method for screening compounds to determine their usefulness in reducing diarrhea associated with irinotecan chemotherapy.

Abstract: Disclosed are an LED light source, an LED light source manufacturing method, and their direct display device. The LED light source includes a base, at least an LED chip, an anti-vulcanization structure, a light excitation structure, an encapsulation structure and a protection structure. The LED light source can overcome catalyst poison or vulcanization of the light-emitting material effectively to improve product yield and reliability of the LED light source. In the meantime, the LED light source has the feature of a better light emission performance.

Abstract: Disclosed are an LED light source, an LED light source manufacturing method, and their direct display device. The LED light source includes a base, at least an LED chip, an anti-vulcanization structure, a light excitation structure, an encapsulation structure and a protection structure. The LED light source can overcome catalyst poison or vulcanization of the light-emitting material effectively to improve product yield and reliability of the LED light source. In the meantime, the LED light source has the feature of a better light emission performance.

Abstract: A touch sensor includes an insulative substrate; a first sensing layer, having first sensing strings arranged along a first axis, and a first interval being disposed between every two adjacent first sensing strings; and a second sensing layer, having line paths arranged along a second axis, and a second interval being disposed between every two adjacent line paths. A plurality of the line paths composes a second sensing string. Each second sensing string has an active unit and an inactive unit. The active unit is formed by one or more line paths connected by a crossing line. The line paths of the inactive units are connected to a ground line. The first sensing strings and the second sensing strings are separately orthogonally arranged on two opposite sides of the substrate. The second interval is less than the first interval in width.

Abstract: The invention includes a substrate, a touch sensor layer, an insulative film and a signal transmission layer. The touch sensor layer has sensing columns. Each sensing column has a first sensing electrode and second sensing electrodes. The first sensing electrode is connected to a first contact through a first transparent path. Each second sensing electrode is connected to a second contact through a second transparent path. The second contacts are arranged in the same order of the second sensing electrodes connected thereto. The insulative film covers the second contacts. The signal transmission layer has first signal wires, second signal wires and signal output terminals. Two end of each first signal wire are separately connected to the first contact and one of the signal output terminals. Each second signal wire connects the second contacts in a line and is connected to one of the signal output terminals.

Abstract: Disclosed are an LED light source, an LED light source manufacturing method, and their direct display device. The LED light source includes a base, at least an LED chip, an anti-vulcanization structure, a light excitation structure, an encapsulation structure and a protection structure. The LED light source can overcome catalyst poison or vulcanization of the light-emitting material effectively to improve product yield and reliability of the LED light source. In the meantime, the LED light source has the feature of a better light emission performance.

Abstract: Disclosed are an LED light source, an LED light source manufacturing method, and their direct display device. The LED light source includes a base, at least an LED chip, an anti-vulcanization structure, a light excitation structure, an encapsulation structure and a protection structure. The LED light source can overcome catalyst poison or vulcanization of the light-emitting material effectively to improve product yield and reliability of the LED light source. In the meantime, the LED light source has the feature of a better light emission performance.

Abstract: The invention includes a substrate, a touch sensor layer, an insulative film and a signal transmission layer. The touch sensor layer has sensing columns. Each sensing column has a first sensing electrode and second sensing electrodes. The first sensing electrode is connected to a first contact through a first transparent path. Each second sensing electrode is connected to a second contact through a second transparent path. The second contacts are arranged in the same order of the second sensing electrodes connected thereto. The insulative film covers the second contacts. The signal transmission layer has first signal wires, second signal wires and signal output terminals. Two end of each first signal wire are separately connected to the first contact and one of the signal output terminals. Each second signal wire connects the second contacts in a line and is connected to one of the signal output terminals.