Abstract: The present invention belongs to the technical field of biomedicine, and specifically relates to an extracellular cyclophilin inhibitor and the use thereof, wherein the structural general formula of the extracellular cyclophilin inhibitor of the present invention is as shown in formula (I). According to the present invention, a group capable of reacting with sulfhydryl of cysteine at a specific site on blood albumin is extracted by means of a side chain of a new cyclosporin derivative, and a drug conjugate is rapidly formed after same enters the body, which can effectively restrict the drug to the extracellular area and form targeted inhibition of extracellular cyclophilin, thereby achieving the aim of treating diseases associated therewith.

Abstract: An ion channel blocker for treatment and/or prevention of hepatic fibrosis is provided. Based on the fact that the activation of hepatic stellate cells is an important link in anti-hepatic fibrosis, it is found that gliclazide has the effect of inhibiting the activation of hepatic stellate cells by in vitro and in vivo experiments. Further exploration reveals that gliclazide mainly inhibits the activation of hepatic stellate cells by inhibiting autophagy pathways, and thus the gliclazide can be used to prepare medicaments for treatment and/or prevention of hepatic fibrosis.

Abstract: A silicon carbon composite material includes a carbon matrix and a silicon material, the carbon matrix has a cross-linked porous structure internally, and the silicon material is at least partially distributed in the cross-linked porous structure. A value of flexibility C1 of the silicon carbon composite material satisfies 0.4?C1?2. C1 is a factor by which a compression deformation variable of the silicon carbon composite material is scaled to be equal to its rebound deformation variable, representing flexibility of the silicon carbon composite material. When the C1 value satisfies 0.4?C1?2, the silicon carbon composite material has good flexibility, reducing overall impact of expansion stress of silicon on the silicon carbon composite material, and allowing for a certain degree of contractility of the carbon matrix framework, so that residual stress can be received and released, thereby maintaining overall stability of the silicon carbon composite material.

Abstract: Disclosed is a GNSS receiver, including a state monitoring sensor and a processor. The state monitoring sensor is configured to monitor a state of the GNSS receiver, and generate a first triggering signal according to the state of the GNSS receiver. The processor is configured to switch from a resting operating state to a wake-up operating state according to the first triggering signal, and transmit position information about the GNSS receiver to a remote server at a preset frequency. Further disclosed is a GNSS device.

Abstract: Disclosed are use of an organic acid-containing leaching agent in leaching from an ion-adsorption type rare earth ore and method for leaching full-phase rare earth. A leaching agent containing a reducing organic acid or its compound leaching agent with a chemical leaching agent is used, and H+ or H+-cations in chemical leaching agent undergoes ion exchange so as to leach out an ion-exchangeable phase rare earth. Organic acid anions could complex with rare earth ions to reduce re-adsorption of rare earth ions onto clay minerals. The reducing organic acid could also realize dissolution and leaching of easily dissolved colloidal sediment phase rare earths and mineral phase rare earths. Rare earths that are difficult to dissolve are reduced by the reducing organic acid to form low-valent rare earth ions and leached out, thereby achieving simultaneous enhanced leaching of rare earths from ion-exchangeable phase, colloidal sediment phase, and mineral phase.

Abstract: The invention discloses a method and system for detecting and repairing sun glint in UAV optical RGB ocean image, introduces a sun glint attention module, and constructs a semantic segmentation network model based on attention mechanism. The sun glint region is segmtioned by semantic segmentation network model based on attention mechanism, and the optical flow field of high-resolution UAV optical RGB ocean image is extracted by RAFT optical flow estimation network. sun glint region and optical flow field are used for optical flow propagation to repair the sun glint in UAV optical RGB ocean images and restore the real benthic image features.

Abstract: Lipid nanoparticle (LNP) encapsulating self-amplifying mRNA, compositions, and methods of using the novel nucleic acid constructs and compositions are disclosed. LNP constructs include novel ionizable lipid. Novel sa-mRNA constructs encode a modified SARS-COV-2 spike protein, wherein the polynucleotide has been truncated to not include nucleotides encoding a SARS-COV-2 transmembrane domain and short cytosolic domain amino acids and immunomodulators. Sa-mRNAs are useful in for use as a therapeutic, diagnostic and/or prophylactic agent to mammalian cells or organs.

Abstract: Embodiments of this disclosure provide a method and apparatus for compiling a neural network model, and a method and an apparatus for training an optimization model. The method includes: obtaining a to-be-compiled neural network model; determining an intermediate instruction sequence corresponding to the to-be-compiled neural network model based on the to-be-compiled neural network model; processing the intermediate instruction sequence by using a pre-trained instruction sequence optimization model, to obtain a target optimization parameter corresponding to the intermediate instruction sequence; determining an optimization instruction sequence corresponding to the intermediate instruction sequence based on the target optimization parameter; and converting the optimization instruction sequence into an executable instruction sequence, to obtain a target instruction sequence that is executable by a neural network processor corresponding to the to-be-compiled neural network model.

Abstract: This disclosure relates to a lithium-ion battery with an enhanced electrode structure and methods for forming such an electrode structure. The electrode may comprise a metal current collector and a multi-layered active material coated thereon, which includes a discrete graphite-rich and a discrete silicon-rich layer. The silicon-rich layer is positioned between and in direct contact with the metal current collector and the graphite-rich layer.

Abstract: A pancreatic postoperative diabetes prediction system based on supervised deep subspace learning. A deep convolutional neural network and the MITK software are used to obtain postoperative residual pancreas area, so as to taken as the region-of-interest. Traditional image radiomics features and deep semantic features are extracted from the residual pancreas area, and a high-dimensional image feature set is constructed. Clinical factors related to diabetes, including pancreatic excision rate, fat and muscle tissue components, demographic information and living habits are extracted, and a clinical feature set is constructed. Based on a supervised deep subspace learning network, image and clinical features are represented and fused in subspace in dimensionality reduction, while a prediction model is trained to mine sensitive features highly relevant to the prediction risk of a patient suffering postoperative diabetes mellitus with a high degree of automation and discriminative accuracy.

Abstract: Provided is a laundry treating device.

Abstract: A water-based adhesive applied to wood and bamboo includes a main agent composed of water-soluble polymer, synthetic rubber latex and natural latex and a curing agent selected from isocyanate or quaternary ammonium salt polymer. Wherein, the weight ratio of the main agent to the curing agent is between 200:1 and 1:1; the water-soluble polymer is polyvinyl alcohol and is about 2-30 weight percent of the total solids of the main agent; the synthetic rubber latex is about 2-60 weight percent of the total solids of the main agent; and the natural latex is about 5-90 weight percent of the total solids of the main agent. The present invention provides a formaldehyde-free adhesive and introduces natural and renewable raw materials to reduce dependence on petrochemical products and improve the sustainability of related industries.

Abstract: The present invention provides compounds and methods targeting human lymphotactins, including therapeutic antibodies, pharmaceutical compositions and methods of use thereof, useful in the field of immune-mediated diseases including ulcerative colitis, vitiligo, multiple sclerosis, alopecia areata, psoriasis, type 1 diabetes, and asthma.

Abstract: This application provides a multi-band low noise amplifier, including: an input end, a first input matching network, a second input matching network, a first amplifier, and a second amplifier. The input end is coupled to an antenna and is configured to receive an inter-band carrier aggregation signal, where the inter-band carrier aggregation signal includes a first carrier signal located in a first band and a second carrier signal located in a second band, and the first band is different from and does not overlap the second band. The first input matching network is coupled between the input end and the first amplifier and is configured to perform impedance matching for the first carrier signal. The second input matching network is coupled between the input end and the second amplifier and is configured to perform impedance matching for the second carrier signal.

Abstract: A MEMS speaker is provided, including only a substrate enclosing a cavity, a piezoelectric diaphragm disposed above the substrate and covering the cavity, and a flexible structure layer covering the piezoelectric diaphragm. Both the piezoelectric diaphragm and the flexible structure layer are complete sheet structures, a young modulus of the flexible structure layer is less than a young modulus of the piezoelectric diaphragm, and the young modulus of the flexible structure layer is in a range of 100 MPa to 50 GPa. The MEMS speaker in the present disclosure does away with a harder structure layer and adopts a softer flexible structure layer, which better enhances the displacement and has a more prominent acoustic performance.

Abstract: An electrochemical oxygen pump moves or pumps oxygen molecules with a unique anion conducting layer comprising an anion conducting polymer. These pumps can either be used as high precision oxygen flow meters or as oxygen filters. The system can be plumbed to have air as the inlet and the pump will selectively pump oxygen out, offering another way to remove oxygen from the air, along with distillation or pressure swing absorption.

Abstract: Embodiments of this application provide a communication method, a communication apparatus, and a communication system. A proxy client of a terminal device receives application data traffic from an application client of the terminal device; the proxy client determines first data traffic and second data traffic based on the application data traffic, and the first data traffic, the second data traffic, and the application data traffic include same data; and the proxy client sends the first data traffic to a proxy server by using a first session, and sends the second data traffic to the proxy server by using a second session, where the first session and the second session are redundant sessions for each other. In this solution, the proxy client and the proxy server implement redundant transmission of the application data traffic, to ensure correctness and reliability of data transmission, and help improve user experience.

Abstract: Embodiments herein relate to a temperature-sensing circuit for a semiconductor device. The circuit has a remote temperature-sensing element (RTSE) including a metal thermistor formed in a metal layer on the front side or backside of a substrate. The metal thermistor may be serpentine or spiral shaped. The RTSE communicates with a separate sense circuit at another location such as on the substrate. The RTSE can further include a thin film resistor (TFR) in an adjacent dielectric layer of the stack or within the sense circuit. The RTSE is driven alternately at opposing ends to cancel out the effects of power supply variations. An output voltage which represents a sensed temperature is obtained from a point between the metal thermistor and the TFR for processing by an analog-to-digital converter.

Abstract: A method, an apparatus, and an electronic device for providing product object information are disclosed. The method includes: providing an interactive content in a process of playing a live video content associated with a product object, the interactive content being generated according to a material associated with the product object, and the material being used to describe attributes of the product object; and providing a change process of the interactive content according to the material in a process of responding to interactive operation information inputted by a user, to enable a presentation of multiple attributes of the product object. Through the embodiments of the present disclosure, the product object information can be provided to consumers in a more comprehensive and intuitive manner, so as to help the users to make better shopping decisions.

Abstract: A memory device is provided. The memory device comprises a memory cell, a first power rail and a suppressing circuit. The memory cell is coupled to a word line. The first power rail transmits a first supply voltage. The suppressing circuit comprises a first transistor and a second transistor. The first transistor is diode-connected, coupled to the word line, and disposed at a first layer. The second transistor is diode-connected coupled between the first transistor and the first power rail, and disposed at a second layer under the first layer. The first transistor and the second transistor overlap with each other in a layout view.