Abstract: A device for modelling physiological and pathophysiological states of the brain is provided. The device comprises a hydrogel with micropattern channels having a length, width and depth. The micropattern channels comprise cells selected from the group consisting of neurons, astrocytes, microglia, oligodendrocytes, neuronal organoids, cancer cells, cancer spheroids, brain tumoral cells and combinations thereof.

Abstract: An integrated circuit device having functional circuitry driven by a clock signal includes onboard clock generation circuitry. The clock generation circuitry includes an input configured to accept a frequency reference signal, at least one variable loading capacitor coupled to the input for converting the crystal resonator signal into a calibrated clock signal, and calibration circuitry configured to calibrate the at least one variable loading capacitor based on a reference voltage. The input configured to accept a frequency reference signal may be configured to accept a crystal resonator signal.

Abstract: A display panel and a display terminal are provided. The display panel includes a first substrate, a second substrate, a liquid crystal layer, and an optical adjustment layer. The second substrate is spaced apart from and opposite to the first substrate, and a plurality of protrusions are provided on the surface of the second substrate away from the first substrate. The liquid crystal layer is between the first substrate and the second substrate. The optical adjustment layer is provided on the side of the second substrate away from the first substrate, the optical adjustment layer is provided with a plurality of grooves, and the grooves are fitted with corresponding protrusions. A refractive index of the second substrate is smaller than a refractive index of the optical adjustment layer.

Abstract: The present invention relates to a compound having a benzo seven-membered ring structure, and a preparation method therefor, and use thereof. The compound has a structure as represented by formula (I). Provided is use of the compound having the structure and prepared with the preparation method of the present invention, enantiomers, diastereomers, racemates and mixtures thereof of the compound, as well as chemically acceptable salts, crystalline hydrates and solvent mixtures of the compound and the enantiomers, diastereomers, racemates and mixtures thereof of the compound in the preparation of drugs for treating BET Bromodomain BRD4 activity or expression level related diseases.

Abstract: The present disclosure relates to a power factor correction circuit, a control method, and an electrical appliance. The power factor correction circuit may include: a power regulation branch, including a first switching unit, a second switching unit and a branch sampling resistor connected in series sequentially; an inductive branch, connected between an AC power source and a power regulation branch; a rectifier branch, including a first rectifier unit and a second rectifier unit, the rectifier branch may include a main line sampling resistor; a capacitance branch; a control circuit sampling a branch current flowing through each of the branch sampling resistors and a main line current flowing through the main line sampling resistor respectively, and controlling the switching of each power regulation branch sequentially. With the branch sampling resistor and the main line sampling resistor, the overall cost of the power factor correction circuit may be reduced.

Abstract: Disclosed are a method and control device for adjusting an opening size of a sampling window of a biopsy surgical device. The biopsy surgical device includes a motor, an outer cutter tube and an inner cutter tube. The outer cutter tube includes a sampling window on a side of the front end. The motor drives the inner cutter tube to move axially through a transmission mechanism, changing the axial relative position of the inner cutter tube and the sampling window. The method includes: obtaining an input instruction that includes a set value of an sampling window opening length; determining an axial movement distance of the inner cutter tube according to the current position of the inner cutter tube and the set value; calculating the number of rotations of the motor corresponding to the axial movement distance; and controlling the motor to rotate until the sampling window reaches the opening length.

Abstract: An integrated circuit device having functional circuitry driven by a clock signal includes onboard clock generation circuitry. The clock generation circuitry includes an input configured to accept a frequency reference signal, at least one variable loading capacitor coupled to the input for converting the crystal resonator signal into a calibrated clock signal, and calibration circuitry configured to calibrate the at least one variable loading capacitor based on a reference voltage. The input configured to accept a frequency reference signal may be configured to accept a crystal resonator signal.

Abstract: An integrated circuit device having functional circuitry driven by a clock signal includes onboard clock generation circuitry. The clock generation circuitry includes an input configured to accept a frequency reference signal, at least one variable loading capacitor coupled to the input for converting the crystal resonator signal into a calibrated clock signal, and calibration circuitry configured to calibrate the at least one variable loading capacitor based on a reference voltage. The input configured to accept a frequency reference signal may be configured to accept a crystal resonator signal.

Abstract: An integrated circuit device, having functional circuitry driven by a clock signal, includes a first clock path for accepting an external clock signal where the first clock path includes first biasing circuitry configured to controllably pass the external clock signal, a second clock path for accepting an external frequency reference signal where the second clock path includes internal clock generation circuitry configured to generate an internal clock signal from the external frequency reference signal and second biasing circuitry configured to controllably pass the external frequency reference signal to the internal clock generation circuitry, and selector circuitry configured to select, based on user input, a clock output to drive the functional circuitry of the integrated circuit device. The clock output is selected from between (i) an output of the first clock path, and (ii) an output of the second clock path.

Abstract: An integrated circuit device, having functional circuitry driven by a clock signal, includes a first clock path for accepting an external clock signal where the first clock path includes first biasing circuitry configured to controllably pass the external clock signal, a second clock path for accepting an external frequency reference signal where the second clock path includes internal clock generation circuitry configured to generate an internal clock signal from the external frequency reference signal and second biasing circuitry configured to controllably pass the external frequency reference signal to the internal clock generation circuitry, and selector circuitry configured to select, based on user input, a clock output to drive the functional circuitry of the integrated circuit device. The clock output is selected from between (i) an output of the first clock path, and (ii) an output of the second clock path.

Abstract: An integrated circuit device having functional circuitry driven by a clock signal includes onboard clock generation circuitry. The clock generation circuitry includes an input configured to accept a frequency reference signal, at least one variable loading capacitor coupled to the input for converting the crystal resonator signal into a calibrated clock signal, and calibration circuitry configured to calibrate the at least one variable loading capacitor based on a reference voltage. The input configured to accept a frequency reference signal may be configured to accept a crystal resonator signal.

Abstract: The present disclosure relates to a power factor correction circuit, a control method, and an electrical appliance. The power factor correction circuit may include: a power regulation branch, including a first switching unit, a second switching unit and a branch sampling resistor connected in series sequentially; an inductive branch, connected between an AC power source and a power regulation branch; a rectifier branch, including a first rectifier unit and a second rectifier unit, the rectifier branch may include a main line sampling resistor; a capacitance branch; a control circuit sampling a branch current flowing through each of the branch sampling resistors and a main line current flowing through the main line sampling resistor respectively, and controlling the switching of each power regulation branch sequentially. With the branch sampling resistor and the main line sampling resistor, the overall cost of the power factor correction circuit may be reduced.

Abstract: The present invention relates to a compound having a benzo seven-membered ring structure, and a preparation method therefor, and use thereof. The compound has a structure as represented by formula (I). Provided is use of the compound having the structure and prepared with the preparation method of the present invention, enantiomers, diastereomers, racemates and mixtures thereof of the compound, as well as chemically acceptable salts, crystalline hydrates and solvent mixtures of the compound and the enantiomers, diastereomers, racemates and mixtures thereof of the compound in the preparation of drugs for treating BET Bromodomain BRD4 activity or expression level related diseases.

Abstract: Methods for treating a neurological disorder, such as a traumatic spinal cord injury or traumatic brain injury, or a disorder such as Parkinson's disease or multiple sclerosis are provided. Such methods include administering a therapeutically effective amount of Gsx1 protein (such as a Gsx1-cell penetrating peptide fusion protein), or a nucleic acid molecule encoding such a protein (for example as part of a viral vector), thereby treating the neurological disorder.

Abstract: An intra frame bit rate allocation method being performed by a computer device comprising at least one processor, includes when a current frame of picture is an intra frame in a specified frame sequence, pre-encoding the current frame of picture; calculating a corresponding intra frame encoding cost and an inter frame encoding cost of the pre-encoding; and allocating an intra frame bit rate according to the calculated intra frame encoding cost and the inter frame encoding cost.

Abstract: A wind power converter device is provided. The wind power converter device includes grid side converters, generator side converters and a DC bus module. Each of the grid side converters includes grid side outputs electrically coupled to a grid and a first and a second DC inputs. Each two of the neighboring grid side converters are connected in series at the second and the first DC inputs. Each of the generator side converters includes generator side inputs electrically coupled to a generator device and a first and a second DC outputs. Each two of the neighboring generator side converters are coupled in series at the second and the first DC outputs. The DC bus module is electrically coupled between the grid side converters and the generator side converters.