Patents by Inventor Li-Chien Hsu
Li-Chien Hsu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8753663Abstract: Drug eluting coating compositions are composed of at least one therapeutic agent dispersed in modified, biologically active binders. The therapeutic agents included in the coating composition are paclitaxel, sirolimus, tacrolimus, everolimus, actinomycin-D, dexamethasone, mycophenolic acid, cyclosporins, estradiol, and derivatives and analogs thereof. These therapeutic agents are applied to the surface of the medical device by a modified, biologically active binders. By using these biologically active binders, the therapeutic agents can be applied to at least one surface of a medical implant without using inert polymer carriers.Type: GrantFiled: October 20, 2008Date of Patent: June 17, 2014Assignee: Biotegra, Inc.Inventor: Li-Chien Hsu
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Patent number: 8357386Abstract: A drug coating for a medical device comprises one or more drug composite layers. The drug composite layer comprises one or more therapeutic agents dispersed within one or more modified bioactive binders. The modified bioactive binders are hydrophobic compounds bonded to bioactive binders, and the modified bioactive binders are not inert polymers.Type: GrantFiled: April 28, 2005Date of Patent: January 22, 2013Assignee: BIOTEGRA, Inc.Inventor: Li-Chien Hsu
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Publication number: 20090043388Abstract: Drug eluting coating compositions are composed of at least one therapeutic agent dispersed in modified, biologically active binders. The therapeutic agents included in the coating composition are paclitaxel, sirolimus, tacrolimus, everolimus, actinomycin-D, dexamethasone, mycophenolic acid, cyclosporins, estradiol, and derivatives and analogs thereof. These therapeutic agents are applied to the surface of the medical device by a modified, biologically active binders. By using these biologically active binders, the therapeutic agents can be applied to at least one surface of a medical implant without using inert polymer carriers.Type: ApplicationFiled: October 20, 2008Publication date: February 12, 2009Applicant: BIOVENTION HOLDINGS LTD.Inventor: Li-Chien Hsu
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Patent number: 7468191Abstract: The present invention provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and below the boiling temperature of the FC immiscible hydrophilic liquid, and adding FC to the mixture of step (a) and agitating at the elevated temperature to disperse droplets of FC in the FC immiscible hydrophilic liquid to form the FC emulsion. The invention also provides another method of making an FC emulsion, which does not require a solid emulsifying agent.Type: GrantFiled: May 8, 2006Date of Patent: December 23, 2008Assignee: TherOx, Inc.Inventors: Li-Chien Hsu, Jeffrey L. Creech, Paul J. Zalesky, Margaret A. Kivinski
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Patent number: 7438925Abstract: Drug eluting coating compositions are composed of at least one therapeutic agent dispersed in modified, biologically active binders. The therapeutic agents included in the coating composition are paclitaxel, sirolimus, tacrolimus, everolimus, actinomycin-D, dexamethasone, mycophenolic acid, cyclosporins, estradiol, and derivatives and analogs thereof. These therapeutic agents are applied to the surface of the medical device by a modified, biologically active binders. By using these biologically active binders, the therapeutic agents can be applied to at least one surface of a medical implant without using inert polymer carriers.Type: GrantFiled: April 26, 2003Date of Patent: October 21, 2008Assignee: Biovention Holdings Ltd.Inventor: Li-Chien Hsu
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Patent number: 7357937Abstract: A stable FC emulsion is described. The FC emulsion of the present invention comprises a continuous FC immiscible hydrophilic liquid phase and a dispersed phase comprising FC suspended as droplets within the continuous phase. The emulsion further comprises an emulsifying agent and a stabilizing agent. The stabilizing agent of the present invention reduces the ability of the FC droplets to move within the continuous phase. The present invention also provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and below the boiling temperature of the FC immiscible hydrophilic liquid, and adding FC to the mixture of step (a) and agitating at the elevated temperature to disperse droplets of FC in the FC immiscible hydrophilic liquid to form the FC emulsion.Type: GrantFiled: September 24, 2002Date of Patent: April 15, 2008Assignee: TherOx, Inc.Inventors: Li-Chien Hsu, Jeffrey L. Creech, Paul J. Zalesky, Margaret A. Kivinski
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Patent number: 7198179Abstract: A packaged gas-solubilized product is described. The gas-solubilized product contains a first gas with a first pressure. The product is placed into a flexible inner container made of a gas-impermeable material. The inner container is hermetically disposed inside an outer container. A space formed between the inner and the outer containers is charged with a second gas with an initial charging pressure. The initial charging pressure is higher than the pressure of the first gas contained in the product. Additionally, a product dispenser in a fluid connection with the product contained in the internal container is included. The present invention also provides a method of packaging a gas-solubilized product to prevent a change in the concentration of the gas dissolved in the product during its storage and dispensing.Type: GrantFiled: February 25, 2003Date of Patent: April 3, 2007Assignee: TherOx, Inc.Inventors: John S. Gilkerson, Jeffrey L. Creech, Li-Chien Hsu, Gregory P. Watson
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Publication number: 20060204533Abstract: A drug delivery composition includes a polymer, and one or more drugs and a bioactive polyelectrolyte complex dispersed within the polymer where the polyelectrolyte complex regulate the release of the drugs from the polymer. The bioactive polyelectrolyte complex comprises a polyelectrolyte and an oppositely charged component, wherein the polyelectrolyte and/or the oppositely charged component is bioactive.Type: ApplicationFiled: March 14, 2006Publication date: September 14, 2006Applicant: BIOTEGRA, INC.Inventors: Li-Chien Hsu, Sun-De Tong
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Publication number: 20060193799Abstract: The present invention provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and below the boiling temperature of the FC immiscible hydrophilic liquid, and adding FC to the mixture of step (a) and agitating at the elevated temperature to disperse droplets of FC in the FC immiscible hydrophilic liquid to form the FC emulsion. The invention also provides another method of making an FC emulsion, which does not require a solid emulsifying agent.Type: ApplicationFiled: May 8, 2006Publication date: August 31, 2006Applicant: TherOx, Inc.Inventors: Jeffrey Creech, Li-Chien Hsu, Margaret Kivinski, Paul Zalesky
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Publication number: 20060193878Abstract: The present invention provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and below the boiling temperature of the FC immiscible hydrophilic liquid, and adding FC to the mixture of step (a) and agitating at the elevated temperature to disperse droplets of FC in the FC immiscible hydrophilic liquid to form the FC emulsion. The invention also provides another method of making an FC emulsion, which does not require a solid emulsifying agent.Type: ApplicationFiled: May 8, 2006Publication date: August 31, 2006Applicant: TherOx, Inc.Inventors: Jeffrey Creech, Li-Chien Hsu, Margaret Kivinski, Paul Zalesky
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Publication number: 20050191333Abstract: A drug coating for a medical device comprises one or more drug composite layers. The drug composite layer comprises one or more therapeutic agents dispersed within one or more modified bioactive binders. The modified bioactive binders are hydrophobic compounds bonded to bioactive binders, and the modified bioactive binders are not inert polymers.Type: ApplicationFiled: April 28, 2005Publication date: September 1, 2005Inventor: Li-Chien Hsu
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Publication number: 20040166064Abstract: A packaged gas-solubilized product is described. The gas-solubilized product contains a first gas with a first pressure. The product is placed into a flexible inner container made of a gas-impermeable material. The inner container is hermetically disposed inside an outer container. A space formed between the inner and the outer containers is charged with a second gas with an initial charging pressure. The initial charging pressure is higher than the pressure of the first gas contained in the product. Additionally, a product dispenser in a fluid connection with the product contained in the internal container is included. The present invention also provides a method of packaging a gas-solubilized product to prevent a change in the concentration of the gas dissolved in the product during its storage and dispensing.Type: ApplicationFiled: February 25, 2003Publication date: August 26, 2004Inventors: John S. Gilkerson, Jeffrey L. Creech, Li-Chien Hsu, Gregory P. Watson
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Publication number: 20040057906Abstract: A stable FC emulsion is described. The FC emulsion of the present invention comprises a continuous FC immiscible hydrophilic liquid phase and a dispersed phase comprising FC suspended as droplets within the continuous phase. The emulsion further comprises an emulsifying agent and a stabilizing agent. The stabilizing agent of the present invention reduces the ability of the FC droplets to move within the continuous phase. The present invention also provides a method of making a FC emulsion. The method comprises mixing an FC immiscible hydrophilic liquid and a solid emulsifying agent by agitation at a temperature elevated above the phase transition temperature of the emulsifying agent and below the boiling temperature of the FC immiscible hydrophilic liquid, and adding FC to the mixture of step (a) and agitating at the elevated temperature to disperse droplets of FC in the FC immiscible hydrophilic liquid to form the FC emulsion.Type: ApplicationFiled: September 24, 2002Publication date: March 25, 2004Inventors: Li-Chien Hsu, Jeffrey L. Creech, Paul J. Zalesky, Margaret A. Kivinski
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Publication number: 20040037886Abstract: Drug eluting coating compositions are composed of at least one therapeutic agent dispersed in modified, biologically active binders. The therapeutic agents included in the coating composition are paclitaxel, sirolimus, tacrolimus, everolimus, actinomycin-D, dexamethasone, mycophenolic acid, cyclosporins, estradiol, and derivatives and analogs thereof. These therapeutic agents are applied to the surface of the medical device by a modified, biologically active binders. By using these biologically active binders, the therapeutic agents can be applied to at least one surface of a medical implant without using inert polymer carriers.Type: ApplicationFiled: April 26, 2003Publication date: February 26, 2004Inventor: Li-Chien Hsu
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Patent number: 6340465Abstract: Biocompatible surfaces on medical devices, particularly those formed of synthetic materials, are produced by providing coating compounds having crosslinked regions capable of entrapping biocompatible molecules on the surfaces of medical devices in order to form a stable base layer. The crosslinked base layer is lubricious and is able to function as an entrapping or coupling site for additional biocompatible agents, which agents may be stably incorporated into its crosslinked lattice. Thus, the coatings of the present invention have enhanced lubricity and may also have antimicrobial, protein-repelling, and/or antithrombotic properties. The present invention thus discloses novel, stable, biocompatible coating compositions, devices coated with the compositions of the present invention, methods of making and applying such compounds, and methods of preparing and using devices and apparatus coated with such compositions.Type: GrantFiled: April 12, 1999Date of Patent: January 22, 2002Assignee: Edwards Lifesciences Corp.Inventors: Li-Chien Hsu, Can B. Hu
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Patent number: 6309660Abstract: Universal, biocompatible coating platforms for articles intended to contact physiological fluids or tissues and associated methods of production are disclosed. The coating platforms of the present invention are composed of a polyelectrolyte molecular film containing one or more biologically active compounds. The molecular film is further complexed with the surface of an article by a crosslinked interpenetrating network (IPN) made from at least one multifunctional molecule and at least one crosslinking agent. The IPN may entrap additional biologically active compounds within the coating platform, or additional biologically active compounds may be bound to its outer surface. The coating platform of the present invention is ideally suited for providing medical devices with anti-thrombogenic coatings.Type: GrantFiled: July 28, 1999Date of Patent: October 30, 2001Assignee: Edwards Lifesciences Corp.Inventors: Li-Chien Hsu, Can B. Hu, Sun-De Tong
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Patent number: 5541167Abstract: A composition for coating medical blood contacting surfaces comprises a mixture of an anticoagulant and a defoaming agent. The coating composition is applied by either dipping the device into a solution containing the mixture or by spraying the mixture onto the surface. Alternatively, the surface can be sequentially dip coated and/or sprayed with the individual components. In a preferred embodiment, the anticoagulant is a quaternary ammonium complex of heparin, preferably stearyldimethylbenzyl ammonium heparin, and the antifoaming agent is a mixture of polydimethylsiloxane and silicon dioxide.Type: GrantFiled: October 28, 1994Date of Patent: July 30, 1996Assignee: Baxter International Inc.Inventors: Li-Chien Hsu, Mark E. Loar
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Patent number: 5417969Abstract: Processes for forming a uniform, continuous coating of heparin covalently bonded to blood-contacting polyvinylchloride surfaces of a medical device are disclosed. These processes include coating the polyvinylchloride surfaces with an organic solvent solution of heparin complexed with an organic cation, and then exposing the coated surfaces to ionizing radiation to covalently bind the heparin moiety to the polyvinylchloride. The complex of the coating is formed from a heparin moiety and at least one cationic moiety selected from the group consisting of dimethylstearylamine, polyethyleneimine, benzalkonium, stearylkonium, and tridodecylmethylammonium; the complex is soluble in organic solvents and forms continuous and uniform coatings on polyvinylchloride. Advantageously, the heparin moiety can be bonded to the polyvinylchloride surfaces simultaneously with sterilizing the medical devices using ionizing radiation.Type: GrantFiled: November 18, 1993Date of Patent: May 23, 1995Assignee: Baxter International Inc.Inventors: Li-Chien Hsu, David P. Balding, Lawrence Farhat
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Patent number: 5047020Abstract: A non thrombogenic quaternary ammonium-heparin complex coating for a medical article comprising an amount of at least 50% by weight of one or more cationic quaternary ammonium organic salts having the following formula: ##STR1## Wherein R.sub.1 is an alkyl group having from about 14 to about 22 carbons;R.sub.2 is an alkyl group having from about 1 to about five carbons;R.sub.3 is an alkyl group having from about 1 to about five carbons.Type: GrantFiled: July 31, 1989Date of Patent: September 10, 1991Assignee: Baxter International Inc.Inventor: Li-Chien Hsu
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Patent number: 4871357Abstract: A non thrombogenic quarternary ammonium/heparin complex coating for a medical article is disclosed where the organic cationic salt is an alkylbenzyldimethyl ammonium ion present in an amount of at least 50% by weight and having the following formula: ##STR1## where R is a uniform alkyl group containing between 16 to 18 carbon atoms.Type: GrantFiled: September 14, 1987Date of Patent: October 3, 1989Assignee: Baxter International Inc.Inventors: Li-Chien Hsu, Sun D. Tong