Abstract: The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or ?9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that ?9-nAChR has an activating protein 1 (AP1)-binding site, that the ?9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the ?9-nAChR promoter at the AP1-binding site, indicating that ER-induced ?9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.

Abstract: A biomedical diagnostic device includes a hydrophilic layer, hydrophobic layer, and at least one test pad. The hydrophilic layer includes an exposed introductory portion adapted to introduce a test fluid, and is stacked with the hydrophobic layer with multiple access holes. At least one test pad, each of which includes a distinguishing reaction medium, is disposed in the corresponding holes that extend to contact the hydrophilic layer. The relations within the device are as follows: hydrophilicity of any of the test pads>hydrophilicity of the hydrophilic layer>hydrophilicity of the hydrophobic layer.

Abstract: The invention found that overexpression and activation of ?9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of ?9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of ?9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.

Abstract: The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or ?9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that ?9-nAChR has an activating protein 1 (AP1)-binding site, that the ?9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the ?9-nAChR promoter at the AP1-binding site, indicating that ER-induced ?9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.

Abstract: This invention relates to methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.

Abstract: The invention found that overexpression and activation of ?9-nAChR are associated with tumorigenesis of breast cancer and create a number of small interfering RNAs to inhibit the expression of ?9-nAChR so as to inhibit breast cancer. Therefore, the invention provides small interfering RNAs (siRNAs) for inhibiting expression of ?9-nAChR so as to inhibit breast cancer, methods to prevent/inhibit/treat malignant progression of nicotine-derived-compound-induced breast cancer and method of determining malignant level of such breast cancer.

Abstract: This invention relates to methods of aiding smoking cessation and/or treating and/or preventing smoking addition or methods of treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer, which comprises administering to a subject an effective amount of a tea polyphenol. The invention uses catechins (such as epigallocatechin gallate (“EGCG”), epigallocatechin (“EGC”), epicatechin gallate (“ECG”), epicatechin (“EC”), gallocatechin gallate (“GCG”), gallocatechin (“GC”), catechin gallate (“CG”) and catechin (“C”)) in aiding smoking cessation and/or treating and/or preventing smoking addition or treating and/or preventing nicotine or nicotine-derived compounds or estrogen induced breast cancer.

Abstract: A graphical indicator provided on the surface of an object to represent index information includes a content part and a header part. The content part is spread with a plurality of micro-units and divided into a plurality of state zones. Each state zone is spread with one micro-unit and equally divided into multiple hypothetical sections. The micro-unit is placed in any of the hypothetical sections to form different candidate states. The header part is spread with a plurality of micro-units that are specifically arranged to provide header information used to recognize the graphical indicator.

Abstract: A graphical indicator provided on the surface of an object to represent index information includes a content part and a header part. The content part is spread with a plurality of micro-units and divided into a plurality of state zones. Each state zone is spread with one micro-unit and equally divided into multiple hypothetical sections. The micro-unit is placed in any of the hypothetical sections to form different candidate states. The header part is spread with a plurality of micro-units that are specifically arranged to provide header information used to recognize the graphical indicator.

Abstract: A graphical indicator provided on the surface of an object to represent index information includes a content part and a header part. The content part is spread with a plurality of micro-units and divided into a plurality of state zones. Each state zone is spread with one micro-unit and equally divided into multiple hypothetical sections. The micro-unit is placed in any of the hypothetical sections to form different candidate states. The header part is spread with a plurality of micro-units that are specifically arranged to provide header information used to recognize the graphical indicator.

Abstract: A graphical indicator provided on the surface of an object to represent index information includes a content part and a header part. The content part is spread with a plurality of micro-units and divided into a plurality of state zones. Each state zone is spread with one micro-unit and equally divided into multiple hypothetical sections. The micro-unit is placed in any of the hypothetical sections to form different candidate states. The header part is spread with a plurality of micro-units that are specifically arranged to provide header information used to recognize the graphical indicator.

Abstract: A graphical indicator provided on the surface of an object to represent index information includes a content part and a header part. The content part is spread with a plurality of micro-units and divided into a plurality of state zones. Each state zone is spread with one micro-unit and equally divided into multiple hypothetical sections. The micro-unit is placed in any of the hypothetical sections to form different candidate states. The header part is spread with a plurality of micro-units that are specifically arranged to provide header information used to recognize the graphical indicator.

Abstract: A decorative tree includes a trunk and a transmission structure fixedly mounted the trunk and including a pair of eyeballs, a pair of eyelids, a mouth plate and an electric motor. The transmission structure can make the decorative tree blink eyes and move mouth as desired thereby making the decorative tree look very interesting.