Abstract: A BGA semiconductor package structure that is able to avoid high frequency interference has at least one non-ball mounting area on a bottom face of a substrate, wherein high frequency bump balls are mounted abreast on the non-ball mounting ball area. When the BGA package device is mounted on a PCB, the non-ball mounting area correspond the electric wires, such that the electric wires which are formed on the PCB are able to transmit high frequency signals and connect the high frequency bump balls. Thus, when the high frequency signals are transmitted via the electric wires, the high frequency signals do not affect other signals transmitted via other electric wires.