Patents by Inventor Li-Fan Lu

Li-Fan Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
    Publication number: 20190170729
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Application
    Filed: August 22, 2018
    Publication date: June 6, 2019
    Inventors: Randolph J. NOELLE, Li-Fan Lu, Sergio Quezada, David Gondek
  • Method for modulating inflammatory responses
    Patent number: 8679501
    Abstract: The present invention is a method for inhibiting Treg cell functional activities by blocking Treg cell-mediated mast cell activation. It has been found IL-9 produced by Treg cells activates mast cells, which in turn mediate an amplification loop critical for graft tolerance and immune responses to tumors. Thus, a method for enhancing an immune response to a vaccine, such as a cancer vaccine, is also provided as is a method for increasing cell and humoral immunity in a subject.
    Type: Grant
    Filed: November 1, 2006
    Date of Patent: March 25, 2014
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Cory L. Ahonen
  • REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
    Publication number: 20140004537
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF.
    Type: Application
    Filed: May 22, 2013
    Publication date: January 2, 2014
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Regulatory T cell mediator proteins and uses thereof
    Patent number: 8465740
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: June 18, 2013
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate CD4+ and CD8+ T cell immunity
    Patent number: 8236304
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: August 7, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • REGULATORY T CELL MEDIATOR PROTEINS AND USES THEREOF
    Publication number: 20120195894
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF.
    Type: Application
    Filed: December 15, 2011
    Publication date: August 2, 2012
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Use of PD-L3 proteins and PD-L3 specific antibodies or antibody fragments to regulate D4+ and CD8+ T cell immunity
    Patent number: 8097249
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNF. Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Grant
    Filed: April 24, 2006
    Date of Patent: January 17, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Regulatory T Cell Mediator Proteins and Uses Thereof
    Publication number: 20080287358
    Abstract: The present invention relates to novel regulatory T cell proteins. One protein, designated PD-L3, resembles members of the PD-L1 family, and co-stimulates ?CD3 proliferation of T cells in vitro. A second, TNF-like, protein has also been identified as being upregulated upon ?CD3/?GITR stimulation. This protein has been designated Treg-sTNE Proteins, antibodies, activated T cells and methods for using the same are disclosed.
    Type: Application
    Filed: April 24, 2006
    Publication date: November 20, 2008
    Inventors: Randolph J. Noelle, Li-Fan Lu, Sergio Quezada, David Gondek
  • Method for Modulating Inflammatory Responses
    Publication number: 20080220006
    Abstract: The present invention is a method for inhibiting Treg cell functional activities by blocking Treg cell-mediated mast cell activation. It has been found IL-9 produced by Treg cells activates mast cells, which in turn mediate an amplification loop critical for graft tolerance and immune responses to tumors. Thus, a method for enhancing an immune response to a vaccine, such as a cancer vaccine, is also provided as is a method for increasing cell and humoral immunity in a subject.
    Type: Application
    Filed: November 1, 2006
    Publication date: September 11, 2008
    Inventors: Randolph J. Noelle, Li-Fan Lu, Cory L. Ahonen