Abstract: The instant invention discloses methods and compositions for the treatment of cancer. The invention relates methods and compositions for specifically targeting free radical accumulation as a means of preferentially eliminating neoplastic cells. The combination of an SOD inhibitor (2-methoxyestrdiol) with free radical-producing agents results in a means of eliminating tumor cells through the accumulation of intracellular superoxide anion.

Abstract: The present invention relates to an optical network including a bridge for selectively transferring information from an optical channel carried on a first WDM optical waveguide to at least two optical channels on a second WDM optical waveguide. The first and second optical waveguides carry WDM optical signals each having plural optical channels. A bridge is interposed between the first and second optical waveguides which includes an optical add-drop multiplexer optically communicating with each waveguide. At least one optical channel having first and second data bits streams is dropped from the first waveguide. The first and second data bit streams are respectively encoded on two different optical channels which are then added to the second optical waveguide.

Abstract: The present invention relates to an optical network including a bridge for selectively transferring information from an optical channel carried on a first WDM optical waveguide to at least two optical channels on a second WDM optical waveguide. The first and second optical waveguides carry WDM optical signals each having plural optical channels. A bridge is interposed between the first and second optical waveguides which includes an optical add-drop multiplexer optically communicating with each waveguide. At least one optical channel having first and second data bits streams is dropped from the first waveguide. The first and second data bit streams are respectively encoded on two different optical channels which are then added to the second optical waveguide.

Abstract: Disclosed is a method for the comprehensive analysis of nucleic acid samples and a detector composition for use in the method. The method, referred to as Binary Encoded Sequence Tags (BEST), involves generation of a set of nucleic acid fragments; adding an adaptor to the ends containing recognition site for cleavage at a site offset from the recognition site; cleaving the fragment to generate fragments having a plurality sticky ends; indexing of the fragments into sets based on the sequence of sticky ends. The fragments are indexed by adding a offset adaptor to newly generated ends. A different adaptor will be coupled to each different sticky end. The resulting fragments—which will have defined ends, be of equal lengths (in preferred embodiment), and a central sequence derived from the source nucleic acid molecule—are binary sequence tags. The binary sequence tags can be used and further analyzed in numerous ways.

Abstract: The present invention provides a flexible WDM optical communication system in which each optical channel of the WDM optical communication signal can simultaneously accept multiple data formats. In one embodiment, the WDM optical system includes an optical waveguide having an optical add-drop multiplexer to selectively add and/or drop one or more optical channels to/from the WDM signal carried on the waveguide. A first source of data imparts information onto a first optical channel in a packet format while a second source of data imparts information onto the first optical channel in a time division multiplexed format. Other data sources having other data formats may also be included. An optical network interface electrically communicates with the data sources, placing the data from these sources onto the first optical channel which is generated from an optical source such as a laser. An optical path carries the optical channel from the optical source to the optical add-drop multiplexer.

Abstract: The present invention relates to a bidirectional optical network including a bridge for selectively transferring information from an optical channel carried on a first bidirectional WDM optical waveguide to at least two optical channels on a second bidirectional WDM optical waveguide. The first and second bidirectional optical waveguides each carry two counter-propagating WDM optical signals each having plural channels. A bridge is interposed between the first and second bidirectional optical waveguides which includes an optical add-drop multiplexer optically communicating with each bidirectional waveguide. At least one optical channel having first and second data bits streams is dropped from the first bidirectional waveguide. The first and second data bit streams are respectively encoded on two different optical channels which are then added to the second bidirectional optical waveguide.

Abstract: The present invention provides a flexible WDM optical communication system in which each optical channel of the WDM optical communication signal can simultaneously accept multiple data formats. In one embodiment, the WDM optical system includes an optical waveguide having an optical add-drop multiplexer to selectively add and/or drop one or more optical channels to/from the WDM signal carried on the waveguide. A first source of data imparts information onto a first optical channel in a packet format while a second source of data imparts information onto the first optical channel in a time division multiplexed format. Other data sources having other data formats may also be included. An optical network interface electrically communicates with the data sources, placing the data from these sources onto the first optical channel which is generated from an optical source such as a laser. An optical path carries the optical channel from the optical source to the optical add-drop multiplexer.

Abstract: Disclosed is a method for the comprehensive analysis of nucleic acid samples and a detector composition for use in the method. The method, referred to as Fixed Address Analysis of Sequence Tags (FAAST), involves generation of a set of nucleic acid fragments having a variety of sticky end sequences; indexing of the fragments into sets based on the sequence of sticky ends; associating a detector sequence with the fragments; sequence-based capture of the indexed fragments on a detector array; and detection of the fragment labels. Generation of the multiple sticky end sequences is accomplished by incubating the nucleic acid sample with one or more nucleic acid cleaving reagents. The indexed fragments are captured by hybridization and coupling, preferably by ligation, to a probe. The method allows a complex sample of nucleic acid to be quickly and easily cataloged in a reproducible and sequence-specific manner.

Abstract: A flash card management apparatus has a progression of compartments that govern or direct which cards are reviewed at a given drill session. When the progression is ordered by card capacities, a given card will come up for review possibly at each drill session for the first few sessions, and then come up for review with ever decreasing frequency thereafter. The use of the management apparatus will assure that each card will be not only periodically reviewed, but also reviewed a fixed number of times before it is put on the side.

Abstract: A composition of a hydrocarbon in water colloidal dispersion including hydrocarbon particles having a mean softening point exceeding 95° C., a water soluble dispersion agent and water, process and apparatus for the production thereof are disclosed. These dispersions have a median particle size below about 4.5 microns and 90% of the hydrocarbon particles have a size less than about 60 microns. These dispersions are storage stable, stable towards transportation, and can be pumped without destabilizing.

Abstract: Equine rhinovirus 1 (ERhV1) is a respiratory pathogen of horses which has an uncertain taxonomic status. The nucleotide sequence of the ERhV1 genome and amino acid sequence have been substantially determined (FIG. 2). The predicted polyprotein was encoded by 6,741 nucleotides and possessed a typical picornavirus proteolytic cleavage pattern, including a leader polypeptide. The genomic structure and predicted amino acid sequence of ERhV1 were more similar to those of foot-and-mouth disease viruses (FMDV), the only members of the aphthovirus genus, than other picornaviruses. Nucleotide sequences coding for the complete polyprotein, the polymerase, and VP1 were analyzed separately. The phylogenetic trees confirmed that ERhV1 was more closely related to aphthoviruses than to other picornaviruses. Virion proteins and virus-like particles are described and probes, primers, antigens, vectors, diagnostics and tests developed.

Abstract: A pancake cooking apparatus has an elongate and preferably open-ended griddle and a batter scraper by which a mass of batter is spread from one end of the griddle to the other. Thickness uniformity is realized by structures for keeping the scraper's edge and the griddle's cooking surface spaced a fixed distance apart during the batter spreading step. The pancake cooking apparatus at times includes a plurality of side-by-side griddles for high-volume manual cooking operations. A method for cooking uniformly thin, rectangular pancakes uses the cooking apparatus.

Abstract: A desktop paper shredder including a housing in which a pair of shafts are rotationally mounted. The housing is provided with an entrance that corresponds to and is aligned with the shafts. A paper trash container is removably disposed at the lower portion of the housing. The shafts are driven by a driving device and meshed with each other such that their rotations are opposite to each other. Each shaft is further provided with a spiral groove in which a plurality of sets of shredding blades are disposed therein. Each of the sets of shredding blades is spaced from the next set of shredding blades by a spacing collar on which is provided a paper trash stopper. The external end portion of each paper trash stopper is fixedly attached to the configuring tab within the housing. The perimeter of each shredding blade is further provided with a plurality of knives. Each shredding blade is further provided with a projecting tab that rests in a selected spiral groove.

Abstract: A circuit for detecting timing errors and for selecting the correct clock edge for mid-point data sampling, includes a rising edge sampling device for sampling an input data signal at a rising edge of an input clock and generating a first interim data signal. A falling edge sampling device samples the input data signal at a falling edge of the input clock and generates a second interim data signal. An error signal generation devise, arranged in each of the rising edge and falling edge sampling devices, generates an error signal if designated setup time and hold time requirements are not met. The error signal is one of an error-rise or error-fall signal. A state machine receives the first and second interim signals and the error signal. The state machine automatically outputs the first interim data signal to a logic device if the error-fall signal is detected, and outputs the second interim data signal to the logic device if the error-rise signal is detected.