Abstract: A solid dispersion, a preparation method therefor, and a solid formulation comprising same. The solid dispersion comprises compound A and a pharmaceutically acceptable matrix polymer, wherein the pharmaceutically acceptable matrix polymer includes an enteric high-molecular polymer and a non-enteric high-molecular polymer, and the compound A is 1-{(6-[(1-methyl)-4-pyrazolyl]-imidazo[1,2-a]pyridine)-3-sulfonyl}-6-[(1-methyl)-4-pyrazolyl]-1-hydro-pyrazolo[4,3-b]pyridine. The solid dispersion can significantly improve the solubility and dissolution stability of the compound A, prolong the supersaturation maintenance time of a drug, and further improve the bioavailability of the drug. The in vivo bioavailability of a solid formulation prepared from the solid dispersion meets the requirement of oral administration of the compound A.

Abstract: Certain aspects of the present disclosure generally relate to electronic components and, more particularly, to radio frequency front-end (RFFE) circuitry. One example apparatus may include a controller configured to: determine a first calibration point and a second calibration point for an amplifier, wherein the first calibration point is associated with a first supply voltage for the amplifier, and wherein the second calibration point is associated with a second supply voltage for the amplifier; and determine an operating point for the amplifier by interpolating based on the first calibration point and the second calibration point, the operating point being associated with a third supply voltage. The apparatus may also include an interface configured to control a power supply to provide the third supply voltage associated with the operating point for the amplifier.

Abstract: Improved systematic inversion methodology applied to formation testing data interpretation with spherical, radial and/or cylindrical flow models is disclosed. A method of determining a flow line parameter includes determining a diverse set of flow models and selecting at least one flow model from the diverse set of flow models representative, at least in part, of a formation tester tool, at least one formation, at least one fluid, and at least one flow of the at least one fluid. The method further includes lowering the formation testing tool into the at least one formation to intersect with the formation at least one formation and sealing a probe of the formation tester placed in fluid communication with the at least one formation. The method further includes initiating flow from the at least one formation and utilizing the at least one selected flow model to predict the flow line parameter.

Abstract: A smart oral cleaner includes a tooth-cleaning component, the tooth-cleaning component includes a first wall body and a second wall body, a hollow structure is formed between the first wall body and the second wall body, the second wall body is recessed towards the first wall body, the second wall body has a first wall surface and a second wall surface arranged opposite to one another, the first wall surface and the second wall surface are provided with jet holes, the second wall body has a shape adapted to a shape of a tooth, and an end surface of the tooth-cleaning component is in a shape of a slope-shaped depression.

Abstract: A smart oral cleaner includes a tooth-cleaning component, the tooth-cleaning component includes a first wall body and a second wall body, a hollow structure is formed between the first wall body and the second wall body, the second wall body is recessed towards the first wall body, the second wall body has a first wall surface and a second wall surface arranged opposite to one another, the first wall surface and the second wall surface are provided with jet holes, the second wall body has a shape adapted to a shape of a tooth, and an end surface of the tooth-cleaning component is in a shape of a slope-shaped depression.

Abstract: An electronic device and a method for reducing power consumption of signal transmission in the electronic device are provided. The electronic device may include a source circuit, a destination circuit, at least one transmission wire and at least one resonance wire, wherein the at least one transmission wire is coupled between at least one output terminal of the source circuit and at least one input terminal of the destination circuit, and the at least one resonance wire is coupled to the at least one input terminal of the destination circuit and is routed along the at least one transmission wire. In specific, the source circuit is configured to output an oscillation signal having an oscillation frequency, the destination circuit is configured to receive the oscillation signal, wherein the at least one transmission wire is configured to transmit the oscillation signal from the source circuit to the destination circuit.

Abstract: Improved systematic inversion methodology applied to formation testing data interpretation with spherical, radial and/or cylindrical flow models is disclosed. A method of determining a parameter of a formation of interest at a desired location comprises directing a formation tester to the desired location in the formation of interest and obtaining data from the desired location in the formation of interest. The obtained data relates to a first parameter at the desired location of the formation of interest. The obtained data is regressed to determine a second parameter at the desired location of the formation of interest. Regressing the obtained data comprises using a method selected from a group consisting of a deterministic approach, a probabilistic approach, and an evolutionary approach.

Abstract: Provided is an isolated antigen-binding protein, wherein the drug is used for the treatment of tumor, and the isolated antigen-binding protein comprises a PD-L1 binding moiety and an OX40 binding moiety, wherein: the OX40 binding moiety is capable of recognizing and/or binding amino acid residues G70 and/or F71 in a human OX40 extracellular domain; and the PD-L1 binding moiety is capable of recognizing and/or binding amino acid residues I54, Y56, E58, Q66 and/or R113 in an N-terminal IgV domain of human PD-L1. Further provided is a use of the isolated antigen-binding protein in preparing a drug, wherein the drug is used for the treatment of tumors.

Abstract: A telemetry system is disclosed for use in a wellbore extending from the surface. The telemetry system includes fiber optic cable locatable in the wellbore, the fiber optic cable including at least one optical fiber. The telemetry system also includes a telemetry device operable to transmit an optical telemetry signal over the fiber optic cable. An optical detector operably connected to the optical fiber and includes a single-photon detector operable to receive the optical telemetry signal transmitted over the optical fiber.

Abstract: Gas bubble migration can be managed in liquids. In one example, a system can execute wellbore-simulation software to simulate changes in gas dissolution in a liquid over time. This may involve dividing the wellbore into segments spanning from the well surface to the downhole location, each segment spanning a respective depth increment between the well surface and the downhole location. Next, for each time, the system can determine a respective multiphase-flow regime associated with each segment of the plurality of segments based on a simulated pressure level, a simulated temperature, a simulated pipe eccentricity, and a simulated fluid velocity at the segment. The system can also determine how much of the gas is dissolved in the liquid at each segment based on the respective multiphase-flow regime at the segment. The system can display a graphical user interface representing the gas dissolution in the liquid over time.

Abstract: The present invention relates to the field of medical biology, and discloses a single domain antibody and derivative proteins thereof against CTLA4. In particular, the present invention discloses a CTLA4 binding protein and the use thereof, especially the use for treating and/or preventing CTLA4 relevant diseases such as tumor.

Abstract: A gain equalizer and a method for controlling a tunable gain of the gain equalizer are provided. The gain equalizer includes a common source stage and a switch array. The common source stage is configured to apply the tunable gain to an input signal, in order to generate an amplified signal. The common source stage includes input transistors and cascode transistors, wherein the cascode transistors are respectively coupled to the input transistors. The input transistors are configured to receive the input signal via gate terminals of the input transistors, respectively, and the cascode transistors are configured to output the amplified signal via drain terminals of the cascode transistors, respectively. In addition, the switch array is coupled between respective source terminals of the cascode transistors, wherein the tunable gain is controlled according to an equivalent impedance of the switch array.

Abstract: A variable gain low noise amplifier (LNA) and a method for controlling a gain of the variable gain LNA are provided. The variable gain LNA may include a first transistor, a first degeneration inductor, a second transistor and a second degeneration inductor, wherein the first degeneration inductor is coupled to a source terminal of the first transistor, and the second degeneration inductor is coupled to a source terminal of the second transistor. Gate terminals of the first transistor and the second transistor are configured to receive an input signal. The first transistor and the first degeneration inductor belong to a first branch of the variable gain LNA, and the second transistor and the second degeneration inductor belong to a second branch of the variable gain LNA. More particularly, a gain of the variable gain LNA is determined by controlling whether to turn off the second branch.

Abstract: An electronic device and a method for reducing power consumption of signal transmission in the electronic device are provided. The electronic device may include a source circuit, a destination circuit, at least one transmission wire and at least one resonance wire, wherein the at least one transmission wire is coupled between at least one output terminal of the source circuit and at least one input terminal of the destination circuit, and the at least one resonance wire is coupled to the at least one input terminal of the destination circuit and is routed along the at least one transmission wire. In specific, the source circuit is configured to output an oscillation signal having an oscillation frequency, the destination circuit is configured to receive the oscillation signal, wherein the at least one transmission wire is configured to transmit the oscillation signal from the source circuit to the destination circuit.

Abstract: A telemetry system is disclosed for use in a wellbore extending from the surface. The telemetry system includes fiber optic cable locatable in the wellbore, the fiber optic cable including at least one optical fiber. The telemetry system also includes a telemetry device operable to transmit an optical telemetry signal over the fiber optic cable. An optical detector operably connected to the optical fiber and includes a single-photon detector operable to receive the optical telemetry signal transmitted over the optical fiber.

Abstract: This disclosure presents a process for communications in a borehole containing a fluid or drilling mud, where a conventional mud pulser can be utilized to transmit data to a transducer. The transducer, or a communicatively coupled computing system, can perform pre-processing steps to correct the received data using an average of a moving time window of the received data, and then normalize the corrected data. The corrected data can then be utilized as inputs into a machine learning mud pulse recognition network where the data can be classified and an ideal or clean pulse waveform can be overlaid the corrected data. The overlay and the corrected data can be fed into a conventional decoder or decoded by the disclosed process. The decoded data can then be communicated to another system and used as inputs, such as to a well site controller to enable adjustments to well site operation parameters.

Abstract: The invention discloses a strontium ferrite-based sacrificial mortar and its preparation method, the strontium ferrite-based sacrificial mortar mainly comprises 720-1000 parts of sulphoaluminate cement, 100-300 parts of strontium ferrite, 600-650 parts of quartz sand, 400-450 parts of water and 0.01-35 parts of superplasticizer. The preparation process is simple, and the strontium ferrite-based sacrificial mortar can be prepared by using a conventional forced single horizontal shaft concrete mixer. The obtained mortar has excellent working performance, compressive strength and corrosion resistance. It can be used in the current third and future fourth generation nuclear power plant core catchers, and has obvious engineering application value.

Abstract: A downhole telemetry method and system are disclosed. In some embodiment, a method includes driving a pulser device based on an input data stream, wherein driving the pulser device includes generating modulated pressure pulses including modulated pulse shapes within a fluid telemetry medium. In some embodiments in which bi-modulation is utilized, the method further includes driving the pulser device including modulating pressure pulses including pulse position modulating pressure pulses.

Abstract: Disclosed is a metal-semiconductor contact structure based on two-dimensional (2D) semimetal electrodes, including a semiconductor module and a metal electrode module, where the semiconductor module is a 2D semiconductor material, and the metal electrode module is a 2D semimetal material with no dangling bonds on its surface; the 2D semiconductor material and the 2D semimetal material are interfaced with a Van der Waals interface with a surface roughness of 0.01-1 nanometer (nm) and no dangling bonds on the surface, the 2D semiconductor material and the 2D semimetal material are spaced less than 1 nm apart.

Abstract: A formation test probe and a formation test system and method for implementing a self-drilling probe are disclosed. In some embodiments, a test probe includes a body having a channel therethrough to a frontside port, and further includes drill-in tubing disposed within the channel and having a front tip that is extensible from the frontside port. An exciter is disposed within the body in contact with the drill-in tubing and operably configured to induce resonant vibration in the drill-in tubing during a drill-in phase of a formation test cycle.