Patents by Inventor Li-Hsien Wang
Li-Hsien Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20180271071Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: ApplicationFiled: June 6, 2018Publication date: September 27, 2018Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Li-Hsien Wang, Anthony T. Dore, IV, Sean Stevens, Andrew J. Murphy
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Patent number: 10004211Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: GrantFiled: November 14, 2016Date of Patent: June 26, 2018Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Anthony T. Dore, Jr., Sean Stevens, Andrew J. Murphy
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Patent number: 9888693Abstract: The dumpling wrapping device contains a filling provision member, two wrapping members, and two shaping members. The filling provision member distributes dumpling fillings to feed two production lines of dumplings, each involving a wrapping member and a shaping member. Two pairs of rotors in the filling provision member drives dumpling fillings towards the wrapping members through two tubes. The wrapping members wrap the dumpling fillings from the tubes with dough. The dough wrapped fillings are pressed by the shaping members into dumplings of desired shape and size. Positioning members are configured under the shaping members so that the shaping members can be conveniently replaced and cleaned.Type: GrantFiled: September 3, 2015Date of Patent: February 13, 2018Assignee: ANKO FOOD MACHINE CO., LTD.Inventors: Li Hsien Wang, Ge Wei Chao, Sung Yang Chen
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Publication number: 20180000056Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R? gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human C IL-4R? locus.Type: ApplicationFiled: September 15, 2017Publication date: January 4, 2018Applicant: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Yingzi Xue, Andrew J. Murphy, Sean Stevens
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Publication number: 20170311580Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R?, gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human CIL-4R? locus.Type: ApplicationFiled: July 14, 2017Publication date: November 2, 2017Applicant: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Yingzi Xue, Andrew J. Murphy, Sean Stevens
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Patent number: 9743647Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R? gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human C IL-4R? locus.Type: GrantFiled: July 6, 2015Date of Patent: August 29, 2017Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Yingzi Xue, Andrew Murphy, Sean Stevens
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Patent number: 9622460Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: GrantFiled: June 9, 2016Date of Patent: April 18, 2017Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Anthony T. Dore, Jr., Sean Stevens, Andrew J. Murphy
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Publication number: 20170064967Abstract: The dumpling wrapping device contains a filling provision member, two wrapping members, and two shaping members. The filling provision member distributes dumpling fillings to feed two production lines of dumplings, each involving a wrapping member and a shaping member. Two pairs of rotors in the filling provision member drives dumpling fillings towards the wrapping members through two tubes. The wrapping members wrap the dumpling fillings from the tubes with dough. The dough wrapped fillings are pressed by the shaping members into dumplings of desired shape and size. Positioning members are configured under the shaping members so that the shaping members can be conveniently replaced and cleaned.Type: ApplicationFiled: September 3, 2015Publication date: March 9, 2017Inventors: LI HSIEN WANG, GE WEI CHAO, SUNG YANG CHEN
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Publication number: 20170055506Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: ApplicationFiled: November 14, 2016Publication date: March 2, 2017Applicant: Regeneron Pharmaceuticals, Inc.Inventors: Li-Hsien Wang, Anthony T. Dore, JR., Sean Stevens, Andrew J. Murphy
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Patent number: 9565841Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R? gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human C IL-4R? locus.Type: GrantFiled: May 7, 2015Date of Patent: February 14, 2017Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Yingzi Xue, Andrew Murphy, Sean Stevens
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Publication number: 20160278352Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: ApplicationFiled: June 9, 2016Publication date: September 29, 2016Applicant: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Anthony T. Dore, JR., Sean Stevens, Andrew J. Murphy
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Patent number: 9392777Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: GrantFiled: June 10, 2015Date of Patent: July 19, 2016Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Anthony T. Dore, Jr., Sean Stevens, Andrew J. Murphy
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Patent number: 9221894Abstract: Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity Fc?R locus, and wherein the mouse is capable of expressing a functional FcR?-chain. Genetically modified mice are described, including mice that express low affinity human Fc?R genes from the endogenous Fc?R locus, and wherein the mice comprise a functional FcR?-chain. Genetically modified mice that express up to five low affinity human Fc?R genes on accessory cells of the host immune system are provided.Type: GrantFiled: October 7, 2014Date of Patent: December 29, 2015Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Lynn Macdonald, Naxin Tu, Cagan Gurer, Li-Hsien Wang, Sean Stevens, Andrew J. Murphy
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Publication number: 20150320022Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R? gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human C IL-4R? locus.Type: ApplicationFiled: July 6, 2015Publication date: November 12, 2015Inventors: Li-Hsien Wang, Yingzi Xue, Andrew Murphy, Sean Stevens
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Publication number: 20150320021Abstract: Non-human animals comprising a human or humanized IL-4 and/or IL-4R? nucleic acid sequence are provided. Non-human animals that comprise a replacement of the endogenous IL-4 gene and/or IL-4R? gene with a human IL-4 gene and/or IL-4R? gene in whole or in part, and methods for making and using the non-human animals, are described. Non-human animals comprising a human or humanized IL-4 gene under control of non-human IL-4 regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4-encoding sequence with human IL-4-encoding sequence at an endogenous non-human IL-4 locus. Non-human animals comprising a human or humanized IL-4R? gene under control of non-human IL-4R? regulatory elements is also provided, including non-human animals that have a replacement of non-human IL-4R?-encoding sequence with human or humanized IL-4R?-encoding sequence at an endogenous non-human C IL-4R? locus.Type: ApplicationFiled: May 7, 2015Publication date: November 12, 2015Inventors: Li-Hsien Wang, Yingzi Xue, Andrew Murphy, Sean Stevens
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Publication number: 20150272092Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: ApplicationFiled: June 10, 2015Publication date: October 1, 2015Applicant: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Anthony T. Dore, JR., Sean Stevens, Andrew J. Murphy
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Patent number: 9125386Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: GrantFiled: September 19, 2014Date of Patent: September 8, 2015Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Anthony T. Dore, Jr., Sean Stevens, Andrew J. Murphy
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Patent number: 9078418Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: GrantFiled: September 19, 2014Date of Patent: July 14, 2015Assignee: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Anthony T. Dore, Jr., Sean Stevens, Andrew J. Murphy
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Publication number: 20150024412Abstract: Genetically modified non-human animals and methods and compositions for making and using them are provided, wherein the genetic modification comprises a deletion of the endogenous low affinity Fc?R locus, and wherein the mouse is capable of expressing a functional FcR?-chain. Genetically modified mice are described, including mice that express low affinity human Fc?R genes from the endogenous Fc?R locus, and wherein the mice comprise a functional FcR?-chain. Genetically modified mice that express up to five low affinity human Fc?R genes on accessory cells of the host immune system are provided.Type: ApplicationFiled: October 7, 2014Publication date: January 22, 2015Inventors: Lynn Macdonald, Naxin Tu, Cagan Gurer, Li-Hsien Wang, Sean Stevens, Andrew J. Murphy
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Publication number: 20150013022Abstract: Mice that comprise a replacement of endogenous mouse IL-6 and/or IL-6 receptor genes are described, and methods for making and using the mice. Mice comprising a replacement at an endogenous IL-6R? locus of mouse ectodomain-encoding sequence with human ectodomain-encoding sequence is provided. Mice comprising a human IL-6 gene under control of mouse IL-6 regulatory elements is also provided, including mice that have a replacement of mouse IL-6-encoding sequence with human IL-6-encoding sequence at an endogenous mouse IL-6 locus.Type: ApplicationFiled: September 19, 2014Publication date: January 8, 2015Applicant: REGENERON PHARMACEUTICALS, INC.Inventors: Li-Hsien Wang, Anthony T. Dore, JR., Sean Stevens, Andrew J. Murphy