Abstract: A building construction robot is provided. The building construction robot includes a vehicle body, a feeding assembly is arranged in the vehicle body, a mounting frame is fixedly connected to one end of the vehicle body, and the mounting frame is located at a discharge end close to the feeding assembly. One end of a vibrating assembly is fixedly connected to one end of a top of the vehicle body, and the other end of the vibrating assembly passes through a middle part of the mounting frame. A leveling assembly is arranged at one end, away from the vehicle body, of the mounting frame, a measuring part is arranged at a top of the mounting frame, and a moving part is arranged at a bottom of the vehicle body.

Abstract: The present application provides a biological active peptide from seawater pearl, the sequence of which is Ile-Pro-Ser-Thr-Thr-Pro-Phe-Pro-Ser-Thr-Thr-Val-Ala-Thr-Thr-Thr-Met, and the name of which is SCOL polypeptide. The biological active peptide can improve an ACE2 enzyme activity to 3.76 times, and can be applied in preparation of a drug improving an ACE2 activity, treating hypertension, anti-heart failure, anti-tissue fibrosis, anti-inflammation, and type 2 diabetes mellitus and the complication thereof, and relieving neuropathic pain. The biological active peptide can be specifically bound to the ACE2, effectively inhibits the 65% binding between novel coronavirus S protein and the ACE2, can be applied in preparation of an anti-coronavirus infection drug as an inhibitor, and specifically applied in preparation of anti-novel coronavirus drug.

Abstract: A control circuit of a BMS, a battery management system, and an electric vehicle are provided. The control circuit of the BMS may include: a charge-discharge switching module, a freewheel module, and a control module, where the charge-discharge switching module is connected between a battery and a load; the freewheel module is connected in parallel with the load; the control module is connected to the charge-discharge switching module and the freewheel module, respectively, and configured to generate a first control signal and a second control signal; the charge-discharge switching module is configured to be turned off in response to the first control signal; and the freewheel module is activated in response to the second control signal when the charge-discharge switching module is turned off.

Abstract: The invention provides compositions and methods for treating, reducing or preventing cytokine storm, for example, in connection with a viral infection (e.g., by SARS-CoV-2), drug treatment or therapy, trauma or an inflammatory disease, or a related disease and disorder.

Abstract: The present disclosure provides a method and system for quantifying a degree of blending of virgin and aged asphalt in HRAM. The method includes the following steps: first, constructing a relational equation between the microscale modulus of recycled asphalt in a fully blended state and the content of the aged asphalt; measuring the microscale modulus of the recycled asphalt, the microscale modulus of the aged asphalt, the microscale modulus of the virgin asphalt, and the content of the aged asphalt in the HRAM in situ; inputting the dates above into the relational equation to obtain the microscale modulus of the recycled asphalt in the fully blended state; and based on the microscale modulus of the recycled asphalt measured in situ and the microscale modulus of the recycled asphalt in the fully blended state, obtaining the degree of blending of the virgin and aged asphalt in the HRAM.

Abstract: A method of foaming and shaping a thermoplastic sheet comprising a poly(phenylene ether), a polyetherimide, or a combination thereof includes foaming the thermoplastic sheet with supercritical carbon dioxide to form a foamed thermoplastic sheet, and shaping the foamed thermoplastic sheet to form a shaped foamed thermoplastic sheet. The shaping step includes compressing the foamed thermoplastic sheet between a first metal plate and a secondi metal plate, each of which has a grooved surface facing the thermoplastic sheet. The first metal plate and the second metal plate are connected by a flexible, compressible linkage capable. When the flexible, compressible linkage is in its uncompressed state, only the second (lower) metal plate is in contact with the shaped foamed thermoplastic sheet. When the flexible, compressible linkage is in its compressed state, both the first (upper) and second (lower) metal plates are in contact with the shaped foamed thermoplastic sheet.

Abstract: Disclosed are a light emitting diode element, a manufacturing method thereof, and a light emitting apparatus. In the light emitting diode element, a surface of a first bond layer formed on an epitaxial structure is a smooth surface without height difference. Further, a surface roughness thereof may be less than 10 nm. Therefore, when the substrate and epitaxial structure are bonded, the two bond layers are plane-to-plane bonded, and no defect such as voids occurs to ensure the bonding strength. Thereby, the bonding stability between the substrate and the epitaxial structure is ensured, and the yield of the device is improved. At the same time, there is no similar defect such as voids, which facilitates to reduce the voltage of the device and improve the photoelectric efficiency of the device.

Abstract: The disclosure provides compositions and methods relating to aromatic-cationic peptides. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof. For example, the peptides may be administered to subjects in need of a mitochondrial-targeted antioxidant.

Abstract: The present disclosure provides a magnetic nano-drug with double targeting vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR), and a preparation method and application thereof, and belongs to the technical field of biomedicine. The magnetic nano-drug of the present disclosure includes aminated ZnFe2O4 hollow porous magnetic nano-particles, lactate dehydrogenase-silk fibroin (LDH-SF), ethylene dichloride (EDC), and n-hydroxy succinimide (NHS). A mass ratio of the aminated ZnFe2O4 hollow porous magnetic nano-particles to the EDC to the NHS to the LDH-SF is (5-10):(1-5):(1-6):(1-8).

Abstract: A recombinant collagen and a preparation method and use thereof, and in particular, a full-length collagen a1 chain produced through recombinant expression, and a preparation method and use thereof are provided. When a variant (which is denoted as a1 (I) M1) of a human type I collagen a1 chain (a1 (I) chain) and a variant (which is denoted as a1 (II) M6) of a human type II collagen a1 chain (a1 (II) chain) constructed in the present disclosure are produced through recombinant expression in Pichia pastoris, a main degradation product (a main degradation band) in substantially the same proportion as a target product (a target band) of a full-length a1 chain occurring during the recombinant expression of native full-length a1 (I) chain and a1 (II) chain is eliminated, and a yield of the target product is improved.

Abstract: A preparation method of a Lentinula edodes polysaccharide rich in ?-glucan includes: (1) extracting the Lentinula edodes polysaccharide to obtain a filtrate; (2) concentrating the filtrate to obtain a supernatant; (3) precipitating a crude Lentinula edodes polysaccharide from the supernatant using anhydrous ethanol to obtain a first precipitate; and (4) purifying the first precipitate to obtain the Lentinula edodes polysaccharide. The Lentinula edodes polysaccharide rich in the ?-glucan has stable quality, and its yield, polysaccharide content and ?-glucan content are significantly improved compared with water extraction and alcohol precipitation methods in the related art. In vitro pharmacological experiments prove that the Lentinula edodes polysaccharide rich in the ?-glucan has good anti-inflammatory activity and can be applied to preparation of drugs or health foods.

Abstract: A metal powder preparation system and method are provided. The metal powder preparation system includes a medium frequency smelting furnace, a homogeneous insulated quantitative pouring furnace, a precision-controlled liquid level temperature pouring ladle, and a plurality of groups of atomization mechanisms connected in sequence. The present application improves the preparation quality of the metal powder, so that the parameters such as the powder particle size, sphericity, fluidity, oxygen content, component distribution, and particle size distribution of the metal powder can all meet the requirements of high-quality metal additive manufacturing, achieving efficient and continuous preparation of the metal powder at the same time.

Abstract: The present disclosure provides a magnetic nano-drug with double targeting vascular endothelial growth factor (VEGF)-vascular endothelial growth factor receptor (VEGFR), and a preparation method and application thereof, and belongs to the technical field of biomedicine. The magnetic nano-drug of the present disclosure includes aminated ZnFe2O4 hollow porous magnetic nano-particles, lactate dehydrogenase-silk fibroin (LDH-SF), ethylene dichloride (EDC), and n-hydroxy succinimide (NHS). A mass ratio of the aminated ZnFe2O4 hollow porous magnetic nano-particles to the EDC to the NHS to the LDH-SF is (5-10):(1-5):(1-6):(1-8). The magnetic nano-drug according to the present disclosure can position a VEGF ligand through magnetic targeting of hollow zinc ferrite particles, use magnetic particles to regulate reprogramming of macrophages in an intervertebral disc so as to indirectly regulate down-regulation of the VEGF, and inhibit angiogenesis.

Abstract: The invention provides various novel compositions of berberine in combination with pharmacologically active organic acids, and related methods of their use in treating various diseases or disorders. The invention further provides various novel compounds prepared from berberine and pharmacologically active organic acids and prepared from ursodeoxycholic acid and pharmacologically active organic bases, and pharmaceutical compositions thereof, and methods of their preparation and therapeutic use in treating and/or preventing various diseases or disorders.

Abstract: The disclosure relates to a bioactive molecule conjugate, preparation methods and use thereof, particularly relates to a novel bioactive molecule conjugate obtained by improving coupling of the drug and the targeting moiety in an ADC or SMDC, as well as its preparation method and use in the manufacture of a medicament for the treatment of a disease associated with an abnormal cell activity.

Abstract: An ultra-wideband (UWB) ranging method comprises determining, by a first device, that the first device is within proximity of a second device. Responsive to the determination, the first device negotiates a value to use as a UWB session key for securing UWB communications with the second device. The negotiation occurs via a communication protocol different from a UWB communication protocol. The first device controls a UWB subsystem therein to encrypt information communicated via the UWB subsystem based on the negotiated value of the UWB session key instead of a default value for the UWB session key that is specified in the UWB communication protocol. The information facilitates determining the distance between the first device and the second device.

Abstract: The invention generally relates to solid forms of berberine ursodeoxycholate, and to pharmaceutical compositions, and methods of preparation and therapeutic use thereof. In particular, the invention relates to solid forms of berberine ursodeoxycholate and pharmaceutical compositions thereof useful in treating and/or preventing various diseases or disorders, including metabolic disorders, heart diseases, neurodegenerative diseases and liver diseases.

Abstract: The present disclosure provides compositions and methods for engineered cellular compositions and methods of immunotherapy utilizing the same. Compositions of the present disclosure for immune cell regulation comprise a chimeric antigen receptor polypeptide, a T cell receptor polypeptide, and combinations thereof.

Abstract: The present invention provides an engineered immune cell targeting BCMA and use thereof. In particular, the present invention provides a CAR specifically targeting BCMA, the CAR comprising an antigen-binding domain which is an S-derived scFv, an antibody heavy chain variable region as shown in SEQ ID NO: 9 and an antibody light chain variable region as shown in SEQ ID NO: 10. The present invention also provides a CAR-T cell comprising the CAR, a double CAR- and CAR-T cell comprising the S-derived scFv, and related use thereof. Compared to CAR-T cells constructed using other scFvs, the constructed CAR-T cell of the present invention has a better killing effect and tumor elimination capability.

Abstract: In some embodiments, the present disclosure provides an algorithm for a data-driven intelligent adaptive model of an automobile cab based on a biometric identification technology. The algorithm includes the following steps: acquiring driving posture data, the driving posture data including driver information, automobile man-computer parameter information, and seat position information; building a feature extraction model of the driving posture data and screening feature vectors playing a significant role in predicting a seat position by the feature extraction model; building a prediction model of a comfortable seat position by a back propagation (BP) neural network and inputting the screened feature vectors to perform training on the prediction model; and inputting specific feature vectors to obtain the seat position information and accordingly adjust the seat position.