Abstract: Compounds having the following formula I or a stereoisomer or pharmaceutically-acceptable salt thereof, where all substituents are as defined herein, are inhibitors of USP1 useful for treating diseases including, among others, treating proliferative, metabolic, allergic, autoimmune and inflammatory diseases.

Abstract: In accordance with an embodiment, a method includes: mapping, based on an attribute of a protocol data unit (PDU) set, a PDU in the PDU set to one or more transmission paths, wherein each transmission path of the one or more transmission paths has a different characteristic; and sending the PDU in the PDU set on the one or more transmission paths, where a quantity of the one or more transmission paths is less than or equal to a quantity of attribute values of a same type of attribute of the PDU set.

Abstract: A reflective quality of service QoS method and an apparatus are provided, to implement uplink layered QoS, and implement more refined uplink QoS management. The method includes: A terminal device determines to enable a first reflective QoS manner, and determines a first rule in the first reflective QoS manner. The first rule includes a QoS rule and/or a QoS flow to data radio bearer DRB mapping rule. The terminal device identifies classification information of a packet in the first reflective QoS manner, where the classification information is for distinguishing between packets in a same internet protocol IP flow.

Abstract: A communication method and apparatus includes: A communication device determines at least one first packet in first duration. The at least one first packet belongs to a same PDU set, the first duration is determined based on a first interval or burst duration, the first interval is a time interval at which the communication device obtains two adjacent PDU sets in time domain, and the burst duration is duration of one PDU set. Then, the communication device sends the at least one first packet.

Abstract: A communication method and apparatus are provided, to resolve a problem that a terminal device cannot perform normal communication on other accesses due to an operation performed on common parameters over some accesses of the terminal device. The method includes: When the terminal device on a first access is switched from a first PLMN to a second PLMN, if a state of the terminal device on a second access is that the terminal device is registering with the first PLMN or has registered with the first PLMN, the terminal device determines not to delete a first mobility management parameter on the first access. If a state of the terminal device on a second access is that the terminal device has not registered with the first PLMN, the terminal device determines to delete a first mobility management parameter on the first access.

Abstract: The method of treating obesity and targeting adipose tissue in a patient may use injection of a polycationic polymer, such as polyamidoamine (PAMAM) generation 3 (P-G3) or a PCL-g-PAMAM Denpol, that when delivered intraperitoneally, selectively targets visceral adiposity due to its high charge density. P-G3 treatment of obese mice inhibits visceral adiposity, increases energy expenditure, prevents obesity, and alleviates associated metabolic dysfunctions. The extracellular matrix of adipose tissue is enriched with glycosaminoglycans, the known biomacromolecules with the strongest negative charge. P-G3 uncouples adipocyte lipid synthesis and storage from adipocyte development, creating adipocytes with normal functions but that are deficient in hypertrophic growth. The visceral fat distribution of P-G3 is further enhanced by modifying P-G3 with cholesterol to form lipophilic nanoparticles, effective in treating obesity.

Abstract: This application discloses a TSN time synchronization method and apparatus. One example method includes: a first apparatus receives a first TSN time synchronization message from a second apparatus; the first apparatus determines that the first TSN time synchronization message does not carry a first time, where the first time is a system time of a wireless communication system when the second apparatus receives the first TSN time synchronization message; and the first apparatus locally obtains a bridge residence time, write the bridge residence time into the first TSN time synchronization message, and send the first TSN time synchronization message.

Abstract: A communication method and apparatus. A user plane network element perform refined differentiated processing on different data packets to adapt to and meet different user requirements and network conditions. A first user plane network element receives a first data packet, where the first data packet carries first indication information. The first user plane network element processes the first data packet based on the first indication information. The first indication information includes one or more of the following: synchronous transmission indication information, packet discard indication information, data type indication information, charging indication information, statistics indication information, or priority indication information.

Abstract: A security context update method and a communication apparatus are provided. The method is performed by a terminal, and includes: storing a security context of first access and a security context of second access when the first access of the terminal and the second access of the terminal enter a deregistered state. The first access is one of 3GPP access and non-3GPP access, the second access is the other of the 3GPP access and the non-3GPP access, and the first access and the second access are different. According to the method, when the terminal supports multiple records for multiple registration, storage occasions of NAS security contexts corresponding to the 3GPP access and the non-3GPP access are provided.

Abstract: A thin film transistor includes a base, a first electrode, an active pattern, a gate insulating layer, a gate and a second electrode. The active pattern includes a first semiconductor pattern, a second semiconductor pattern and a third semiconductor pattern. A material of one of the first semiconductor pattern and the third semiconductor pattern includes a semiconductor material and N-type doped ions, and a material of another of the first semiconductor pattern and the third semiconductor pattern includes the semiconductor material and P-type doped ions. An orthogonal projection of the gate on the base is non-overlapping with an orthogonal projection of the active pattern on the base.

Abstract: The present disclosure provides an array substrate, an electronic device and a manufacturing method of the array substrate. The array substrate includes a base substrate, and a first transistor and a second transistor on the base substrate, a first electrode of the first transistor being connected to a second electrode of the second transistor; the array substrate further includes a photodiode including a first electrode, a second electrode, and a photosensitive layer between the first electrode and the second electrode, and the first electrode is electrically connected to a gate of the first transistor. In the arrangement, the first transistor and the second transistor are connected in series to form one control unit, and the uniformity and stability of the control unit are greatly improved.

Abstract: The present disclosure generally relates to compounds useful as immunomodulators. Provided herein are compounds, compositions comprising such compounds, and methods of their use. The disclosure further pertains to pharmaceutical compositions comprising at least one compound according to the disclosure that are useful for the treatment of various diseases, including cancer and infectious diseases.

Abstract: The present invention provides an electrostatic charge detecting packaging device comprising a carrier, multiple dies, and multiple electrostatic-charge-sensitive components; the carrier has a surface; the dies are mounted on the surface of the carrier; and the electrostatic-charge-sensitive components are mounted on the surface of the carrier; since an electrostatic voltage tolerance of each of the electrostatic-charge-sensitive components is lower than an electrostatic voltage tolerance of each of the dies, accumulated electrostatic charges are more likely to discharge towards the electrostatic-charge-sensitive components than towards the dies, and as such, by electrically testing whether the electrostatic-charge-sensitive components are functioning normally when packaging the dies, the present invention allows personnel to debug for knowing which packaging steps exactly cause more serious problems that lead to damaging electrostatic discharges in the dies.

Abstract: In a communication method, a session management function network element initiates a procedure of a first operation for a first session; the session management function network element receives a request to establish user-plane resources for the first session from an access and mobility management function network element in a process of performing the first operation; and the session management function network element determines a subsequent procedure based on the first operation.

Abstract: A cell selection method includes receiving, by an access stratum (AS) of a terminal device, first information from a non-access stratum (NAS) of the terminal device. The first information includes identity information of a first public land mobile network (PLMN) to be accessed by the terminal device. The cell selection method also includes determining, by the AS based on the first information, whether to camp on a first candidate cell. The first candidate cell supports the first PLMN. The first candidate cell satisfies a first camping condition. The first camping condition comprises a cell selection criterion and a service requirement. The service requirement is a preset threshold of a parameter reflecting signal quality of a cell.

Abstract: A communication method includes indicating, by a first device to a second device, that the first device is configured in a first mode, wherein a current protocol version of the first device is incompatible with a current protocol version of the second device. The communication method further includes receiving, by the first device, protocol information from the second device, wherein the protocol information is useable by the first device to update the current protocol version of the first device. The communication method further includes updating, by the first device, the current protocol version of the first device based on the protocol information.

Abstract: A communication method and apparatus are provided for transmitting packets of a data stream between user equipment. After receiving a first packet from a first user equipment, a user plane function (UPF) forwards the first packet to a second user equipment at a first moment, so that the first packet that arrives at the UPF before the first moment is not forwarded to the second user equipment until the first moment, to support deterministic sending and ensure that a time sensitive communication (TSC) packet is sent at a determined moment, so as to provide deterministic delay assurance for applications such as industrial control and telemedicine.

Abstract: This application discloses a method for configuring an EPS NAS security algorithm, and a related apparatus in the field of communication technologies. In the technical solution provided in this application, an access and mobility management function entity needs to determine whether a selected EPS NAS security algorithm has been successfully provided to a terminal device, and after determining that the selected EPS NAS security algorithm has not been successfully provided to the terminal device, the access and mobility management function entity provides the selected EPS NAS security algorithm to the terminal device again. According to the technical solution provided in this application, it is ensured that the access and mobility management function entity can successfully configure the EPS NAS security algorithm for the terminal device.

Abstract: Disclosed herein are compositions and methods for delivering adipose tissue browning agents and/or fat modulating agents.

Abstract: The invention relates to a multi-phase power supply regulator and a temperature balance control method thereof. The method comprises: providing a multi-phase power supply regulator which includes a controller and a plurality of power stages, transmitting a plurality of control signals to the plurality of power stages respectively by the controller. Each of the plurality of power stages includes a temperature sampling unit, wherein outputs of the temperature sampling units are connected in parallel and the plurality of power stages outputs a temperature detection signal. The invention determines one of the plurality of power stages comprising highest temperature by sequentially adjusting the control signals, the temperature of the power stage is reduced, and the temperatures of the multi-phase power supply regulator are balanced.