Abstract: The present invention relates methods for treating thyroid cancer, renal cell carcinoma or hepatocellar carcinoma comprising orally administering to a patient in need of such therapy a therapeutic amount of cabozantinib lauryl sulfate salt, preferably in a capsule form. The method allows the administration of the therapeutic amount of cabozantinib lauryl sulfate salt in a fed state or a fasted state and the administration does not exhibit a food effect.

Abstract: The present invention relates methods for treating thyroid cancer, renal cell carcinoma or hepatocellar carcinoma comprising orally administering to a patient in need of such therapy a therapeutic amount of cabozantinib lauryl sulfate salt, preferably in a capsule form. The method allows the administration of the therapeutic amount of cabozantinib lauryl sulfate salt in a fed state or a fasted state and the administration does not exhibit a food effect.

Abstract: The present invention relates methods for treating chronic myeloid leukemia and/or lymphoblastic leukemia by orally administering to a patient in need of such a therapeutic amount of dasatinib lauryl sulfate salt, preferably in a tablet, capsule or suspension form. The method allows the administration of the therapeutic amount of dasatinib lauryl sulfate salt a fed state or a fasted state and the administration does not exhibit a food effect.

Abstract: A combustion method is disclosed, which includes the steps of mixing fuel and an oxidizer into a mixture, wherein fuel originates from a fuel manifold and the oxidizer originates from an oxidizer manifold, and combusting the mixture in a combustion chamber, the fuel manifold, the oxidizer manifold, and the combustion chamber forming parts of an injector assembly wherein each of the fuel and oxidizer manifolds communicates with the combustion chamber via a plurality of dedicated radially disposed Tesla valves around the combustion chamber each via a corresponding port with only one Tesla valve between the fuel manifold and the corresponding port on the combustion chamber and with only one Tesla valve between the oxidizer manifold and the corresponding port on the combustion chamber, wherein the plurality of Tesla valves substantially eliminate reverse flow of exhaust gases from the combustion chamber back to the fuel manifold or the oxidizer manifold.

Abstract: The present invention relates to cabozantinib lauryl sulfate salt and methods of use.

Abstract: The present invention relates to capsules comprising dasatinib lauryl sulfate salt.

Abstract: A combustion method is disclosed, which includes the steps of mixing fuel and an oxidizer into a mixture, wherein fuel originates from a fuel manifold and the oxidizer originates from an oxidizer manifold, and combusting the mixture in a combustion chamber, the fuel manifold, the oxidizer manifold, and the combustion chamber forming parts of an injector assembly wherein each of the fuel and oxidizer manifolds communicates with the combustion chamber via a plurality of dedicated radially disposed Tesla valves around the combustion chamber each via a corresponding port with only one Tesla valve between the fuel manifold and the corresponding port on the combustion chamber and with only one Tesla valve between the oxidizer manifold and the corresponding port on the combustion chamber, wherein the plurality of Tesla valves substantially eliminate reverse flow of exhaust gases from the combustion chamber back to the fuel manifold or the oxidizer manifold.

Abstract: A hydrogen-free carbon film polymer lubricating material and a preparation method and use thereof are disclosed. In the method, a graphite target is used as the target material, and a magnetron sputtering deposition is performed on a surface of the polymer substrate, thereby physically depositing and forming a hydrogen-free carbon film on the surface of the polymer substrate, thereby obtaining a hydrogen-free carbon film polymer lubricating material.

Abstract: A rotating detonation engine (RDE) is disclosed which includes a housing, an injector assembly disposed within the housing, the injector assembly includes a fuel manifold, an oxidizer manifold, and a combustion chamber, fuel from the fuel manifold and an oxidizer from the oxidizer manifold are combined and combusted in the combustion chamber, each of the fuel and oxidizer manifolds communicates with the combustion chamber via a plurality of Tesla valves each via a corresponding port, wherein the plurality of Tesla valves substantially eliminate reverse flow of exhaust gases from the combustion chamber back to the fuel manifold or the oxidizer manifold.

Abstract: The present invention relates to a stable varenicline solid oral dosage form.

Abstract: The present invention relates to cabozantinib lauryl sulfate salt and methods of use.

Abstract: A hydrogen-free carbon film polymer lubricating material and a preparation method and use thereof are disclosed. In the method, a graphite target is used as the target material, and a magnetron sputtering deposition is performed on a surface of the polymer substrate, thereby physically depositing and forming a hydrogen-free carbon film on the surface of the polymer substrate, thereby obtaining a hydrogen-free carbon film polymer lubricating material.

Abstract: The present disclosure relates to a structural coating and preparation method and use thereof. The structural coating provided in the present disclosure includes a titanium transition layer and platinum-hafnium composite structure layers laminated in sequence on a surface of a substrate; the number of the platinum-hafnium composite structure layer is ?3; the platinum-hafnium composite structure layer includes a hafnium layer and a platinum layer laminated in sequence.

Abstract: A rotating detonation engine (RDE) is disclosed which includes a housing, an injector assembly disposed within the housing, the injector assembly includes a fuel manifold, an oxidizer manifold, and a combustion chamber, fuel from the fuel manifold and an oxidizer from the oxidizer manifold are combined and combusted in the combustion chamber, each of the fuel and oxidizer manifolds communicates with the combustion chamber via a plurality of Tesla valves each via a corresponding port, wherein the plurality of Tesla valves substantially eliminate reverse flow of exhaust gases from the combustion chamber back to the fuel manifold or the oxidizer manifold.

Abstract: The present invention relates to kinase inhibitor C8-C16 aliphatic sulfate salts, compositions containing kinase inhibitor C8-C16 aliphatic sulfate salts and uses thereof.

Abstract: The present invention relates to capsules comprising dasatinib lauryl sulfate salt.

Abstract: The present invention relates to polymorphic forms of dasatinib lauryl sulfate salt.

Abstract: The present invention relates to polymorphic forms of dasatinib lauryl sulfate salt.

Abstract: The present invention relates to kinase inhibitor C8-C16 aliphatic sulfate salts, compositions containing kinase inhibitor C8-C16 aliphatic sulfate salts and uses thereof.