Abstract: The present disclosure provides engineered WNT agonists and methods of treating gastrointestinal disorders with modulators of the WNT signaling pathway.

Abstract: In an embodiment a lamp includes a light source having a light source circuit board and a light emitting element arranged on the light source circuit board, a driver configured to drive the light source and having a driving circuit board and a driving electronic element arranged on the driving circuit board, a connector connectable to a power source, wherein the driver is connected to the connector such as to be spatially separated from the light source and a heat sink inside which the light source and the connector are fixedly attached in such a manner that the light source and the driver are radially surrounded by the heat sink, wherein the connector includes a supporting column configured to support the driving circuit board and a retainer configured to hold the driving circuit board.

Abstract: The present invention provides Wnt pathway agonists and related compositions, which may be used in any of a variety of therapeutic methods for the treatment of diseases.

Abstract: An LED light bulb includes a bulb shell, a bulb base, a stem, conductive supports, an LED filament, and a supporting arm. The bulb base is connected to the bulb shell. The stem is connected to the bulb base. The conductive supports are connected to the stem. The LED filament includes a filament body and two conductive electrodes. The conductive electrodes are at two ends of the filament body and connected to the conductive supports. The filament body is around the stem. The supporting arm is connected to the stem and the filament body. In a height direction of the LED light bulb, H is a distance from a bottom to a top of the bulb shell. A first height difference is defined between the two conductive electrodes and is from 0 to 1/10H. The filament body is curved to form a highest point and a lowest point. A second height difference is defined between the highest point and the lowest point. The first height difference is less than the second height difference.

Abstract: An LED filament, comprising: an enclosure; a linear array of LED devices; and an electrical connector, wherein: the enclosure includes an optically transmissive binder; and the linear of LED devices is conformally wrapped around by the enclosure to be operable to emit light when energized through the electrical connector.

Abstract: An LED light bulb includes a bulb shell, a bulb base, a stem, conductive supports, an LED filament, and a supporting arm. The bulb base is connected to the bulb shell. The stem is connected to the bulb base. The conductive supports are connected to the stem. The LED filament includes a filament body and two conductive electrodes. The conductive electrodes are at two ends of the filament body and connected to the conductive supports. The filament body is around the stem. The supporting arm is connected to the stem and the filament body. In a height direction of the LED light bulb, H is a distance from a bottom to a top of the bulb shell. A first height difference is defined between the two conductive electrodes and is from 0 to 1/10H. The filament body is curved to form a highest point and a lowest point. A second height difference is defined between the highest point and the lowest point. The first height difference is less than the second height difference.

Abstract: An LED lamp bulb, comprising: an LED lamp substrate (5) having at least one LED light source (51) mounted thereon; and an electrical isolation assembly (6a) disposed on the LED lamp substrate (5), wherein, the electrical isolation assembly (6a) electrically isolates the LED lamp substrate's charged part from outside of the LED lamp substrate (5). The LED lamp bulb can protect user from contacting the charged part inside the lamp housing (7) when the LED lamp bulb is broken and thereby avoid electric shock accidents. In addition, the directions of the light emitted by the LED light sources (51) can be changed to achieve different kinds of lighting effects.

Abstract: An LED light bulb, comprising: a bulb shell with a lower part and an upper part opposite to the lower part; a bulb base connected with the bulb shell; a heat dissipating element connected with the lower part of the bulb shell and the bulb base, wherein the height of the heat dissipating element is L1 and the maximum height from the heat dissipating element to the upper part of the bulb shell is L2, and the ratio of L1 to L2 is from 1/30 to 1/3; and an LED filament with a plurality of LED chips electrically connected to each other disposed in the bulb shell, two conductive supports, disposed in the bulb shell, a driving circuit, electrically connected with the two conductive supports and the bulb base, a stem disposed in the bulb shell, the LED filament is connected with the stem through the conductive supports.

Abstract: An LED light bulb comprises an LED filament configured for emitting omnidirectional light. The filament comprises a linear array of LED chips operably interconnected to emit light upon energization, a conductive electrode electrically connected with the linear array of LED chips, and a light conversion coating enclosing the linear array of the LED chip and the electrode. The light conversion coating includes a top layer and a base layer conformally interconnected to form a unitary enclosure. The top layer is coated on a first side of the linear array of LED chips and the electrode. The base layer is coated on a second side of the linear array of LED chips and the electrode. A first LED chip in the linear array of LED chips is guided by the unitary enclosure to a different angle in relation to a second LED chip in the linear array of the LED chips.

Abstract: An LED light bulb includes a bulb shell, a bulb base, a stem, conductive supports, an LED filament, and a supporting arm. The bulb base is connected to the bulb shell. The stem is connected to the bulb base. The conductive supports are connected to the stem. The LED filament includes a filament body and two conductive electrodes. The conductive electrodes are at two ends of the filament body and connected to the conductive supports. The filament body is around the stem. The supporting arm is connected to the stem and the filament body. In a height direction of the LED light bulb, H is a distance from a bottom to a top of the bulb shell. A first height difference is defined between the two conductive electrodes and is from 0 to 1/10H. The filament body is curved to form a highest point and a lowest point. A second height difference is defined between the highest point and the lowest point. The first height difference is less than the second height difference.

Abstract: A LED light bulb, consisting of: a bulb shell; a bulb base connected with the bulb shell; a driving circuit disposed in the bulb base; two conductive supports installed in the bulb shell and electrically connected to the driving circuit; a stem disposed in the bulb base; an LED filament module installed in the bulb shell and connected with the stem through the conductive support; at least one supporting arm comprising a hook end and a fixed end, the hook end extends radially from the stand for connecting with one of the connecting portions, and the fixed end is embedded into the stand.

Abstract: An LED light bulb, comprising: a bulb shell with a lower part and an upper part opposite to the lower part; a bulb base connected with the bulb shell; a heat dissipating element connected with the lower part of the bulb shell and the bulb base, wherein the height of the heat dissipating element is L1 and the maximum height from the heat dissipating element to the upper part of the bulb shell is L2, and the ratio of L1 to L2 is from 1/30 to 1/3; and an LED filament with a plurality of LED chips electrically connected to each other disposed in the bulb shell, two conductive supports, disposed in the bulb shell, a driving circuit, electrically connected with the two conductive supports and the bulb base, a stem disposed in the bulb shell, the LED filament is connected with the stem through the conductive supports.

Abstract: An LED light bulb comprises an LED filament configured for emitting omnidirectional light. The filament comprises a linear array of LED chips operably interconnected to emit light upon energization, a conductive electrode electrically connected with the linear array of LED chips, and a light conversion coating enclosing the linear array of the LED chip and the electrode. The light conversion coating includes a top layer and a base layer conformally interconnected to form a unitary enclosure. The top layer is coated on a first side of the linear array of LED chips and the electrode. The base layer is coated on a second side of the linear array of LED chips and the electrode. A first LED chip in the linear array of LED chips is guided by the unitary enclosure to a different angle in relation to a second LED chip in the linear array of the LED chips.

Abstract: An LED light bulb, comprising: a bulb shell; a bulb base connected with the bulb shell to defining a cavity inside the bulb shell, the cavity is filled with air selected from the group consisting of helium and hydrogen, the volume ratio of hydrogen to the overall volume of the cavity is from 5% to 50%; and an LED filament with a plurality of LED chips electrically connected to each other disposed in the bulb shell, at least two conductive supports, disposed in the bulb shell, a driving circuit, electrically connected with the two conductive supports and the bulb base, a stem disposed in the bulb shell, the LED filament is connected with the stem through the conductive supports, and a plurality of supporting arms, connected with and supporting the LED filament.

Abstract: A LED light bulb, consisting of: a bulb shell; a bulb base connected with the bulb shell; a driving circuit disposed in the bulb base; two conductive supports installed in the bulb shell and electrically connected to the driving circuit; a stem disposed in the bulb base; an LED filament module installed in the bulb shell and connected with the stem through the conductive support; at least one supporting arm comprising a hook end and a fixed end, the hook end extends radially from the stand for connecting with one of the connecting portions, and the fixed end is embedded into the stand.

Abstract: An LED filament configured to emit omnidirectional light includes a linear array of LED chips operably interconnected to emit light upon energization and a conductive electrode. The linear array of LED chips is electrically connected with the conductive electrode. A light conversion coating encloses the linear array of the LED chip and the conductive electrode. The light conversion layer includes a top layer and a base layer conformally interconnected to form a unitary enclosure. The top layer is coated on a first side of the linear array of LED chips and the conductive electrode. The base layer is coated on a second side of the linear array of LED chips and the conductive electrode.

Abstract: A lighting device comprises a holder for LED filaments. The holder has a first electrically conductive holding structure and a second electrically conductive holding structure. Each holding structure comprises an essentially longitudinal connection section and an attachment section essentially perpendicular to the connection section.

Abstract: An LED filament module and an LED light bulb are disclosed. The LED filament module includes one or more LED filaments, a first connecting portion, and a second connecting portion. The LED filaments are spaced from each other. Each of the LED filaments includes a first conductive electrode and a second conductive electrode opposite to the first conductive electrode. The first connecting portion is connected with the first conductive electrodes. The second connecting portion is connected with the second conductive electrodes. The LED filament module has a first type. The LED filaments, the first connecting portion, and the second connecting portion of the first type are in a three dimensional form. One or two between the first connecting portion and the second connecting portion of the first type has a torus shape.

Abstract: An LED filament, comprising: an enclosure; a linear array of LED devices; and an electrical connector, wherein: the enclosure includes an optically transmissive binder; and the linear of LED devices is conformally wrapped around by the enclosure to be operable to emit light when energized through the electrical connector.

Abstract: An LED filament, comprising: an enclosure; a linear array of LED devices; and an electrical connector, wherein: the enclosure includes an optically transmissive binder; and the linear of LED devices is conformally wrapped around by the enclosure to be operable to emit light when energized through the electrical connector.