Abstract: The present disclosure relates to compounds and compositions for inhibition of Bcr-Abl tyrosine kinases, methods of preparing said compounds and compositions, and their use in the treatment of various cancers, such as chronic myeloid leukemia (CML).

Abstract: The present disclosure provides a loudspeaker, which includes a frame, a first diaphragm supported on the frame, a first voice coil that drives the first diaphragm to vibrate and sound, a magnetic circuit system with a first magnetic gap, and a first circuit board set between the first diaphragm and the first voice coil. Compared with the related technology, the loudspeaker of the present disclosure guarantees the reliability of the bonding of the first circuit board, the first voice coil and the first diaphragm.

Abstract: The present disclosure discloses a sound device including a frame, a magnet system, a first vibration system and a second vibration system. The magnet system includes a first inner yoke, a main magnet, a side magnet, a first side yoke, and a connection portion. A first coil of the first vibration system is inserted in to a first magnetic gap. A first FPC of the first vibration system includes a first fixation portion, a first welding portion welded to the first coil, and a first elastic portion connecting the first fixation portion with the first welding portion; the first elastic portion is spaced apart from the first side yoke along a vibration direction; the first welding portion is fixed to a side of the first side yoke facing the first diaphragm. The sound device has better magnetic field performance and vibration performance.

Abstract: Provided herein are 7-((3,5-dimethoxyphenyl)amino)quinoxaline derivatives of the general Formula I; and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which X2 is N and Ring A, Ring B, Ring C, X1, X3, R1, L, and W have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, such as e.g. cancer, e g. bladder cancer, brain cancer, breast cancer, cholangiocarcinoma, head and neck cancer, lung cancer, multiple myeloma, rhabdomyosarcoma, urethral cancer and uterine cancer. The present description discloses the preparation of exemplary compounds as well as pharmacological data thereof (e.g. pages 276 to 308; examples 1 to 30; examples A to E; tables CA to EE). An exemplary compound is e.g. 1-(3-(4-(4-(7-((3,5-dimethoxy phenyl) amino)quinoxalin-2-yl)-1H-pyrazol-1-yl)piperidine-1-carbonyl) azetidin-1-yl)prop-2-en-1-one (e.g. example 1).

Abstract: A sound device include a frame, a first vibration system, and a magnetic circuit system. The first vibration system includes a first vibrating diaphragm and a first voice coil. The magnetic circuit system includes a magnetic yoke, a main magnetic steel set, and auxiliary magnetic steel sets. One side, away from the magnetic yoke body, of each of the magnetic yoke extending portions is recessed to form positioning holes. Positioning blocks protruded from the frame are one-to-one inserted into the positioning holes for positioning, and one side, away from the magnetic yoke body, of each of the magnetic yoke extending portions at least partially abuts against the frame, so that the magnetic circuit system and the frame are assembled and positioned along a first direction and a second direction of the magnetic yoke. The sound device is easy to assemble and has excellent acoustic performance.

Abstract: The present disclosure provides the use of ?-1,3-glucan synthase like 5 (GSL5) for the improvement of the clubroot resistance in cruciferous crops as well as related products development, belonging to the area of molecular engineering for plant breeding. GSL5 gene is highly conserved in cruciferous plants and mutation of GSL5 can confer a broad-spectrum and high clubroot resistance to the cruciferous crops, demonstrating that molecular engineering of GSL5 can achieve the improvement of the clubroot resistance in cruciferous crops. The present disclosure provides a key gene and techniques for the improvement of the clubroot disease resistance and durable prevention and control of the clubroot disease in cruciferous crops.

Abstract: The present disclosure provides a method for increasing a number of proteins identified, including: S1. adding a binding buffer and an aluminosilicate zeolite to a sample to be tested to obtain a first suspension; S2. incubating the first suspension, subjecting an incubated first suspension to first high-speed centrifugation to obtain a first supernatant and a first precipitate, discarding the first supernatant, and retaining the first precipitate; S3. repeating a process as follows several times: resuspending the first precipitate with a washing buffer to obtain a second suspension, subjecting the second suspension to second high-speed centrifugation to obtain a second supernatant and a second precipitate, discarding the second supernatant, and retaining the second precipitate; and S4. preparing the second precipitate into a protein sample, and subjecting the protein sample to mass spectrometry detection.

Abstract: The present disclosure relates generally to compounds and compositions thereof for inhibition of ErbB2, including mutant forms of ErbB2, particularly those harboring an Exon 20 mutation, methods of preparing said compounds and compositions, and their use in the treatment or prophylaxis of various cancers, such as lung, glioma, skin, head neck, salivary gland, breast, esophageal, liver, stomach (gastric), uterine, cervical, biliary tract, pancreatic, colorectal, renal, bladder or prostate cancer.

Abstract: A rolling and sliding adaptive device for guiding and fixing a drill pipe includes a mounting platform, where the mounting platform is provided with a through hole for the drill pipe to pass through. Multiple rolling and sliding support mechanisms are arranged around the through hole. The rolling and sliding support mechanisms each include a support seat. The support seat is provided with a contact element telescopic and swingable on the support seat. A telescopic drive mechanism is provided between the contact element and the support seat. The contact elements on the multiple rolling and sliding support mechanisms form a funnel-shaped structure with a large upper part and a small lower part around the through hole. The rolling and sliding adaptive device is used on a deep in-situ high-fidelity coring calibration platform for accurate positioning of an assembly process of a multi-section drill pipe bin.

Abstract: The present disclosure relates to compounds and compositions for inhibition of Bcr-Abl tyrosine kinases, methods of preparing said compounds and compositions, and their use in the treatment of various cancers, such as chronic myeloid leukemia (CML).

Abstract: Disclosed is a method for preparing a composite loaded with nano-magnesium hydride, including: adding a cationic surfactant into an aqueous dispersion of a two-dimensional transition metal carbide such that a nanosheet of the two-dimensional transition metal carbide wrinkles, to avoid re-stacking, and then washing and drying; placing a dried product into a sealed container, vacuuming the sealed container, heating to a high temperature, and holding at the high temperature for a period of time; filling the sealed container with high-pressure hydrogen and holding for a period of time to obtain a heated product; adding the heated product and dibutyl magnesium into an organic solvent, conducting ultrasonic dispersion, then heating under stirring at a hydrogen pressure of 3 MPa to 6 MPa and a temperature of 180° C. to 220° C. for 12 h to 48 h, and centrifuging and drying to obtain the composite loaded with nano-magnesium hydride.

Abstract: A medium-voltage grid-connected photovoltaic inverter system includes: a photovoltaic inverter, a medium-voltage transformer, a medium-voltage switch, and an inverter grid-connected controller. A direct current input terminal of the photovoltaic inverter is connected to a direct current bus. A low-voltage side of the medium-voltage transformer is connected to an alternating current output terminal of the photovoltaic inverter. An input terminal of the medium-voltage switch is connected to a high-voltage side of the medium-voltage transformer, and an output terminal of the medium-voltage switch is configured to be connected to a medium-voltage grid. A current sensor is integrated in the medium-voltage switch to detect a grid-connected current of the photovoltaic inverter system and output a current detection signal.

Abstract: Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which Ring A, Ring B, Ring C, R1, R2, L, Y, and W have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.

Abstract: Disclosed is a service life test apparatus for production of a diaphragm of a diaphragm compressor. The apparatus includes a bottom frame, a test diaphragm head, an oil pressure boosting assembly, a gas pressure boosting assembly and a driving assembly. The test diaphragm head is installed on the bottom frame and is configured to fix the diaphragm. A support frame is installed on the bottom frame. The oil pressure boosting assembly and the gas pressure boosting assembly are installed at positions of two sides of the support frame. Through the arrangement of the test diaphragm head, the pressure boosting assemblies and the driving assembly, a test load may be exerted onto the diaphragm by using gas pressure and oil pressure, and an actual work environment, the received load magnitude and the load distribution condition of the diaphragm may be simulated, so that test results may be more accurate.

Abstract: The disclosure relates to the field of underground salt cavern energy storage, and discloses a coupling numerical simulation method for site selection of an underground salt cavern hydrogen storage, which specifically comprises the following. Geological data of an area where the salt cavern hydrogen storage is to be established is obtained. A three-dimensional model is established and grid meshing is performed. An initial coupling field is established and balanced based on the geological model, and then excavation simulation of the salt cavern hydrogen storage is performed. A geological model after excavation and related parameter values thereof are imported into TOUGH2MP software, a stress model in FLAC3D software is coupled with hydraulic and thermal models in the TOUGH2MP software to simulate a stress, hydraulic, and thermal coupling behavior process of rock layers around the salt cavern hydrogen storage in the area, and a coupled simulation result is obtained.

Abstract: A real-time temperature-pressure detection and rapid processing system for a calibration platform, comprises an inner return pipe, and a water supply pipe is provided therein with an inner water supply pipe. An outer wall of the inner water supply pipe is connected with an inner wall of the water supply pipe through multiple springs. An outer wall of the inner return pipe is connected with an inner wall of a return pipe through multiple springs. The return pipe and the water supply pipe are made of a thermosetting polymer material. The multiple springs, the inner water supply pipe, and the inner return pipe are covered with a heat conducting material. The system further includes a temperature-pressure detection assembly. The assembly includes multiple infrared sensors arranged at two sides of the return pipe and the water supply pipe, a booster pump, a heater, and infrared sensors connected with a control unit.

Abstract: An assembly method for a deep in-situ high-fidelity coring calibration platform includes the following steps: S1: fixing a core bin assembly subsystem on a preset ground foundation and fixing a simulator of a core bin on a mounting base plate of the core bin assembly subsystem; S2: driving a cylinder and driving the mounting base plate to move to a preset position; S3: driving a servo motor and controlling two clips to move close to each other; S4: fixing a drill pipe bin assembly subsystem on the ground foundation; S5: assembling multiple sections of a drill pipe bin in turn; aligning and connecting a bottom of the drill pipe bin to the simulator, and aligning and communicating the top of the drill pipe bin with the lower part of an adaptive drill pipe guide structure; and S6: driving the adaptive drill pipe guide structure to perform accurate positioning.

Abstract: A medium-voltage grid-connected photovoltaic inverter system includes: a photovoltaic inverter, a medium-voltage transformer, a medium-voltage switch, and an inverter grid-connected controller. A direct current input terminal of the photovoltaic inverter is connected to a direct current bus. A low-voltage side of the medium-voltage transformer is connected to an alternating current output terminal of the photovoltaic inverter. An input terminal of the medium-voltage switch is connected to a high-voltage side of the medium-voltage transformer, and an output terminal of the medium-voltage switch is connected to a medium-voltage grid. A voltage sensor is integrated in the medium-voltage switch to detect a line voltage at the high-voltage side of the medium-voltage transformer and a line voltage at a side of the medium-voltage grid and generate a grid-connected voltage detection signal.

Abstract: The present disclosure provides a rolling and sliding adaptive device for guiding and fixing a drill pipe. The rolling and sliding adaptive device includes a mounting platform, where the mounting platform is provided with a through hole for the drill pipe to pass through. Multiple rolling and sliding support mechanisms are arranged around the through hole. The rolling and sliding support mechanisms each include a support seat. The support seat is provided with a contact element telescopic and swingable on the support seat. A telescopic drive mechanism is provided between the contact element and the support seat. The contact elements on the multiple rolling and sliding support mechanisms form a funnel-shaped structure with a large upper part and a small lower part around the through hole.

Abstract: A speaker box includes an upper cover plate, a lower cover plate, a speaker unit, and a motor module. The lower cover plate is assembled with the upper cover plate to define an accommodating cavity for accommodating the speaker unit and the motor module. The speaker unit divides the accommodating cavity into a front cavity and a rear cavity. The motor module is disposed on one side of the speaker unit. The upper cover plate includes a top wall and side walls. A length of at least one of the side walls is greater than a length of an orthographic projection thereof. Edge areas of the upper cover plate and edge areas of the lower cover plate are assembled to define compensation cavities. The lower cover plate is of a single metal sheet structure. Therefore, low-frequency performance of the speaker box is improved.