Abstract: The present invention relates to a CFD numerical simulation based fluid equipment resistance optimization algorithm, including the following steps: establishing a fluid equipment unit library; establishing CFD models of fluid equipment units in the fluid equipment unit library, and obtaining a correspondence between a flow rate and a resistance of each fluid equipment unit based on a CFD model of the fluid equipment unit; obtaining fluid equipment units that constitute to-be-tested fluid equipment, and a quantity and a connection sequence of the fluid equipment units; calculating a resistance of each fluid equipment unit based on a flow rate and a correspondence between the flow rate and the resistance of each fluid equipment unit; and adding up resistances of the fluid equipment units in the to-be-tested fluid equipment based on their connection sequence, to obtain a resistance of the to-be-tested fluid equipment.

Abstract: A pixel circuit, an array substrate, and a display panel. The pixel circuit includes an initializing device, a data writing device, a control device, and a current supplementing device. In a light-emitting phase of a driving period of the pixel circuit, a control signal controls the control device to generate a first driving current, and controls the current supplementing device to generate a second driving current. The first driving current and the second driving current are transmitted to a light-emitting unit, and drive the light-emitting unit together for light emission. Currents flowing through the control device and the current supplementing device, respectively, are reduced while meeting a requirement of providing a large driving current to the light-emitting unit. A control capability of the pixel unit on a current of the light-emitting unit is less likely to be weakened, and a display effect is improved.

Abstract: A pixel circuit, an array substrate, and a display panel. The pixel circuit includes an initializing device, a data writing device, a control device, and a current supplementing device. In a light-emitting phase of a driving period of the pixel circuit, a control signal controls the control device to generate a first driving current, and controls the current supplementing device to generate a second driving current. The first driving current and the second driving current are transmitted to a light-emitting unit, and drive the light-emitting unit together for light emission. Currents flowing through the control device and the current supplementing device, respectively, are reduced while meeting a requirement of providing a large driving current to the light-emitting unit. A control capability of the pixel unit on a current of the light-emitting unit is less likely to be weakened, and a display effect is improved.

Abstract: Described are the discovery, synthesis and pharmacological characterization of ?-opioid receptor-selective positive allosteric modulators (? PAMs). These ? PAMs may increase the affinity and/or efficacy of the orthosteric agonists leu-enkephalin and SNC80, as measured by ?-arrestin recruitment and adenylyl cyclase inhibition. The compounds may be useful pharmacological tools to probe the molecular pharmacology of the ? receptor and to explore the therapeutic potential of ? PAMs in diseases such as chronic pain and depression.

Abstract: The present invention relates to electrochemiluminescent assays for detecting helicase activity. The invention provides a helicase assay that is rapid, sensitive and suitable for high throughput screening for helicase inhibitors. Helicase inhibitors represent a class of pharmacological agents useful for the treatment of disease.

Abstract: The use of triaryl acid derivatives of formula (I) and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.

Abstract: The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.

Abstract: The present invention relates to electrochemiluminescent assays for detecting helicase activity. The invention provides a helicase assay that is rapid, sensitive and suitable for high throughput screening for helicase inhibitors. Helicase inhibitors represent a class of pharmacological agents useful for the treatment of disease.

Abstract: The present invention relates to electorchemiluminescent assays for detecting helicase activity. The invention provides a helicase assay that is rapid, sensitive and suitable for high throughput screening for helicase inhibitors. Helicase inhibitors represent a class of pharmacological agents useful for the treatment of disease.

Abstract: The present invention relates to electorochemiluminescent assays for detecting helicase activity. The invention provides a helicase assay that is rapid, sensitive and suitable for high throughput screening for helicase inhibitors. Helicase inhibitors represent a class of pharmacological agents useful for the treatment of disease.

Abstract: The use of diaryl acid derivatives of formula (I) or pharmaceutically acceptable salts, N-oxides, hydrates or solvates thereof, wherein the variables shown are defined in the disclosure, and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.