Abstract: The present disclosure relates to an AAV capsid having improved liver tissue tropism and stronger exogenous gene expression, and/or improved ability in escaping from neutralizing antibody. The present disclosure further relates to a nucleic acid encoding the AAV capsid, an AAV particle containing the AAV capsid. The present disclosure further relates to a pharmaceutical formulation, which contains (1) the AAV capsid, the nucleic acid, or the AAV particle, and (2) a pharmaceutically acceptable carrier. The present disclosure further relates to the use of the AAV capsid, the nucleic acid, the AAV particle, or the pharmaceutical formulation in the manufacture of a drug for delivering a target gene to mammalian cells. The present disclosure further relates to a method for treating disease, including administration of the pharmaceutical formulation to a subject in need thereof. The present disclosure further relates to a cell containing the nucleic acid.

Abstract: Managing execution of eBPF program capabilities is provided. A comparison of a currently in use helper-id list with an allowable helper-id list of an eBPF program is performed. It is determined whether a set of unallowable helper-ids exists that is included in the currently in use helper-id list but not in the allowable helper-id list based on the comparison. A blocked helper-id list of the eBPF program that includes the set of unallowable helper-ids and a corresponding unallowable capability of each respective unallowable helper-id is generated in response to determining that the set of unallowable helper-ids does exist. The set of unallowable helper-ids and the corresponding unallowable capability of each respective unallowable helper-id is removed from bytecode of the eBPF program in order to have only allowable helper-ids remain in the bytecode along with corresponding allowable capabilities of the eBPF program.

Abstract: The present disclosure provides a recombinant adeno-associated vector comprising a codon-optimized sequence encoding CYP4V2 linked to selected gene expression regulatory sequences and its use in treating Bietti Crystalline Dystrophy (BCD).

Abstract: Provided are a display panel and a driving method thereof, and a display device. The display panel includes: a base substrate; and multiple subpixels provided at the base substrate, at least one of the multiple subpixels including a reflective electrode, wherein the reflective electrode at least includes a first reflective electrode and a second reflective electrode insulated and spaced apart from each other, the first reflective electrode is provided with a first through hole, the second reflective electrode is provided with a second through hole, and an area of the first through hole is different from an area of the second through hole.

Abstract: The present disclosure provides a display device. The display device includes: a liquid crystal display panel; a liquid crystal light control panel located on the light incident side of the liquid crystal display panel; and at least two haze layers located on the light emitting side of the liquid crystal display panel.

Abstract: The present disclosure provides a laser etching system for electrode layer patterning, which can perform electrode layer patterning on the conductive layer of a first surface of the substrate of a double-sided structure touch panel by means of employing a laser beam without damaging the conductive layer on the second surface of the substrate. The system comprises a laser emitter for generating and emitting laser beams, and a laser etching platform for supporting and fixing the touch panel substrate, with the first surface facing the laser beam and the second surface adhering to the laser etching platform. The laser etching system further comprises optical elements, which ensure that the ratio of the spot size of the laser beam irradiated on the second surface to that irradiated on the first surface is not less than 1.2.

Abstract: A virtual surround sound production circuit includes: a subtraction unit configured to perform subtraction operation on first and second signals to output a third signal; a first addition unit configured to perform addition operation on the first and second signals to output a center channel signal; a surround sound adjustment unit configured to adjust the third signal or another third signal that has undergone frequency compensation to output a fourth signal; a center compensation unit configured to adjust the center channel signal to output a fifth signal; a second addition unit configured to perform addition operation on the first, fourth and fifth signals to output a first output signal; a phase inverter unit configured to perform phase inversion on the fourth signal to generate a phase-inverted signal; and a third addition unit configured to perform addition operation on the second, fifth and phase-inverted signals to output a second output signal.

Abstract: The present invention provides a methionine adenosyltransferase 2A inhibitor. The structure of the methionine adenosyltransferase 2A inhibitor is as represented by general formula (I), and the definitions of substituents are as described in the specification. The present invention further provides a preparation method therefor. A compound represented by formula I provided by the present invention has significant methionine adenosyltransferase 2A inhibitory activity, and can be used in the treatment of diseases mediated by overexpression of methionine adenosyltransferase 2A.

Abstract: The present disclosure relates to the field of display technologies and, in particular to a display panel and an electronic device. The display panel comprises: Q rows of first scanning line groups arranged sequentially along a column direction; M columns of second scanning line groups arranged sequentially along a row direction; and at least one gate drive circuit, located on a side of the Q-th row of the first scanning line groups away from the (Q?1)-th row of the first scanning line groups. Each gate drive circuit comprises Q columns of shift register unit groups cascaded in stages. The q-th stage of the shift register unit groups is connected with the q-th row of the first scanning line groups through at least one column of the second scanning line groups. M?Q>1, 1?q?Q, and M, N, Q, q are all positive integers.

Abstract: Provided are an audio synthesis method and apparatus, an electronic device, and a readable storage medium. In the present solution, conversion from a text to an audio having a target timbre is achieved by means of a pre-trained voice synthesis model, the voice synthesis model comprising a first feature extraction sub-model and a second feature extraction sub-model, wherein the first feature extraction sub-model outputs, according to an inputted text to be processed, an acoustic feature comprising a bottleneck feature; the second feature extraction sub-model outputs, according to the inputted first acoustic features, a Mel spectrum feature corresponding to the text to be processed; according to the Mel spectrum feature corresponding to the text to be processed, the target audio corresponding to the text to be processed is obtained, and the target audio has the target timbre.

Abstract: An elevated flooring system having plurality of beams configured to support a respective portion of at least one flooring panel, and at least one saddle configured to support the at least one of the beams. The saddle has a generally horizontally oriented base plate with an alignment post extending generally vertically upwardly from the base plate. The beam has an alignment passage extending through a portion of the bottom of a first end of the beam, wherein the alignment passage is configured to receive a portion of the alignment post of the saddle such that a portion of the beam rests on a portion of the base plate. A method of installing the elevated flooring system includes lowering a first beam and a second beam onto the alignment post of a saddle such that respective portions of the alignment post are received by the alignment passage of the first beam and the alignment passage of the second beam.

Abstract: Methods, apparatus and systems for indicating information in a random access procedure. In one embodiment, a method performed by a wireless communication device is disclosed. The method includes: transmitting, to a wireless communication node, a first message including a preamble and a payload for an access to the wireless communication node; and receiving, from the wireless communication node, a second message including a response to the first message, the second message including an indication indicating a type of the response selected from a plurality of types.

Abstract: This application provides a rotation shaft structure and an electronic device. The rotation shaft structure includes a main shaft assembly, and two folding assemblies. The folding assembly includes a rotation assembly, a support plate, and a housing mounting bracket. The rotation assembly is rotationally connected to the main shaft assembly. The support plate is rotationally connected to the housing mounting bracket and slidably connected to the rotation assembly. When two housing mounting brackets rotate toward each other, two support plates rotate in a same direction relative to the housing mounting brackets on corresponding sides, so that the two support plates and the main shaft assembly can form a triangle-like display accommodation space. When the electronic device is in a closed state, the display accommodation space can be used for accommodating a bent portion of the flexible display, so that the flexible display is not damaged by extrusion.

Abstract: Computer implemented method, systems, and computer program products include program code executing on a processor(s) monitors objects in the technical environment to collect real-time operational data. The program code obtains historical operational data and historical resource data from the technical environment and generates models to evaluate health states and resource states of the one or more objects. The program code applies the models and identifies objects as abnormal. The program code obtains a topology of the technical environment to identify objects impacted by the abnormal object(s). The program code generates a resource aware dynamic operational data collection plan.

Abstract: A socket assembled arch rib and an arch bridge including at least one first monomer, the first monomer includes an inner and outer tube snapped outside the inner tube, a first end of the inner tube protrudes from a first end of the outer tube to form a convex part, a second end is located in the outer tube, the outer tube is filled with concrete, and concrete forms a concave part at a second end of the outer tube for socketing the convex part of the other first monomer; for unfilled concrete area inside the CFST structure arch rib, a double-layer CFST monomer with convex and concave parts formed respectively at the end, and the adjacent monomers are connected with each other through the socket-fit of the convex and concave parts, which is convenient for the sub-monomers to fill the concrete in the steel tube, ensuring dense concrete filling.

Abstract: Particular embodiments described herein provide for an electronic device that can be configured to include a first heat source, a second heat source, and a fan inside a fan enclosure between the first heat source and the second heat source. The fan enclosure includes a main vent to direct air from the fan towards a heatsink and one or more side vents to direct air from the fan towards the first heat source or the second heat source.

Abstract: A display module is provided. The display module includes: a display panel, a light control panel, at least one first circuit board for the display panel, and at least one second circuit board for the light control panel. The display panel and the light control panel) are stacked, the display panel is on a light-emitting side of the light control panel, a light-emitting surface of the display panel is on a first surface, and at least part of an orthographic projection of any one of the at least one first circuit board on the first surface does not overlap with an orthographic projection of the at least one second circuit board on the first surface in a direction perpendicular to the first surface.

Abstract: Disclosed embodiments provide techniques for dynamic data collection. The dynamic data collection includes determining a data generation temporal pattern. Based on the data generation temporal pattern, a data collection strategy is created. The data collection strategy can be based on one or more data collection goals. The data collection strategy can contain specific details on how data is to be collected. A data infrastructure evaluation is performed, which provides pricing models for resources such as electricity and/or network bandwidth. A data collection policy is created based on the data collection strategy and the data infrastructure evaluation. The data collection policy can contain specific details on when data is to be collected and what strategy to use for the collection. A data transfer schedule is created based on the data collection policy. The data transfer schedule determines when to collect data from one or more data source devices.

Abstract: Provided are a display panel and a driving method thereof, and a display device. The display panel includes: a base substrate; and multiple subpixels provided at the base substrate, at least one of the multiple subpixels including a reflective electrode, wherein the reflective electrode at least includes a first reflective electrode and a second reflective electrode insulated and spaced apart from each other, the first reflective electrode is provided with a first through hole, the second reflective electrode is provided with a second through hole, and an area of the first through hole is different from an area of the second through hole.

Abstract: Provided is an array substrate. The array substrate includes: a base substrate, and a plurality of gate lines, a plurality of data lines, a plurality of sub-pixels and a plurality of touch signal lines disposed on the base substrate. The data lines have a plurality of first extending parts and a plurality of second extending parts which are in an alternating arrangement. When the array substrate is used to prepare a liquid crystal display panel and the liquid crystal display panel is displaying, in each column of the sub-pixels, the voltage polarities of the two adjacent sub-pixels which respectively belong to two adjacent first pixel regions are opposite.