Patents by Inventor Li-Xi Yang

Li-Xi Yang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Podophyllotoxin derivatives and their use
    Patent number: 11186594
    Abstract: Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.
    Type: Grant
    Filed: May 19, 2020
    Date of Patent: November 30, 2021
    Assignees: CALIFORNIA PACIFIC MEDICAL CENTER, DIGNITY HEALTH
    Inventor: Li-Xi Yang
  • PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE
    Publication number: 20200277310
    Abstract: Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.
    Type: Application
    Filed: May 19, 2020
    Publication date: September 3, 2020
    Applicants: California Pacific Medical Center, Dignity Health
    Inventor: Li-Xi YANG
  • PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE
    Publication number: 20190077813
    Abstract: Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof; wherein the compound has formula (I): or an N-oxide thereof, or a pharmaceutically acceptable salt of each thereof, or a pharmaceutically acceptable solvate of each of the foregoing, wherein R1 is H or has a structure of: R3 is H, an optionally substituted C1-C8 alkyl, an optionally substituted 3-10 membered cycloalkyl, an optionally substituted 3-10 membered heterocyclyl, an optionally substituted 6-10 membered aryl, or an optionally substituted 5-10 membered heteroaryl; R5 is H or has a structure of: and R11 and R12 independently is an optionally substituted C1-C8 alkyl.
    Type: Application
    Filed: October 27, 2015
    Publication date: March 14, 2019
    Applicants: California Pacific Medical Center, Dignity Health
    Inventor: Li-Xi YANG
  • Podophyllotoxin derivatives and their use
    Patent number: 10087194
    Abstract: Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: October 2, 2018
    Assignees: California Pacific Medical Center, Catholic Healthcare West
    Inventor: Li-Xi Yang
  • PODOPHYLLOTOXIN DERIVATIVES AND THEIR USE
    Publication number: 20170114076
    Abstract: Provided herein are compounds, compositions, and methods for treating cancer in a subject in need thereof.
    Type: Application
    Filed: October 27, 2015
    Publication date: April 27, 2017
    Inventor: Li-Xi Yang
  • Camptothecin derivatives as chemoradiosensitizing agents
    Patent number: 8779138
    Abstract: Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
    Type: Grant
    Filed: January 24, 2011
    Date of Patent: July 15, 2014
    Assignees: Sutter West Bay Hospital, Catholic Healthcare West
    Inventor: Li-Xi Yang
  • Camptothecin derivatives as chemoradiosensitizing agents
    Patent number: 8563537
    Abstract: Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: October 22, 2013
    Assignees: Sutter West Bay Hospital, Catholic Healthcare West
    Inventor: Li-Xi Yang
  • Podophyllotoxin derivatives
    Patent number: 8158809
    Abstract: 4-O esters of podophyllotoxin and 4?-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4?-demethylepipodophyllotoxin. The compounds are useful for treating cancer.
    Type: Grant
    Filed: August 3, 2009
    Date of Patent: April 17, 2012
    Assignees: Sutter West Bay Hospitals, Catholic Healthcare West
    Inventor: Li-Xi Yang
  • CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS
    Publication number: 20110184009
    Abstract: Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
    Type: Application
    Filed: January 24, 2011
    Publication date: July 28, 2011
    Inventor: Li-Xi Yang
  • Camptothecin derivatives as chemoradiosensitizing agents
    Patent number: 7875602
    Abstract: Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
    Type: Grant
    Filed: May 30, 2006
    Date of Patent: January 25, 2011
    Assignees: Sutter West Bay Hospitals, Catholic Healthcare West
    Inventor: Li-Xi Yang
  • PODOPHYLLOTOXIN DERIVATIVES
    Publication number: 20090298870
    Abstract: 4-O esters of podophyllotoxin and 4?-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4?-demethylepipodophyllotoxin. The compounds are useful for treating cancer.
    Type: Application
    Filed: August 3, 2009
    Publication date: December 3, 2009
    Inventor: Li-Xi Yang
  • Podophyllotoxin derivatives
    Patent number: 7605262
    Abstract: 4-O esters of podophyllotoxin and 4?-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4?-demethylepipodophyllotoxin. The compounds are useful for treating cancer.
    Type: Grant
    Filed: January 18, 2008
    Date of Patent: October 20, 2009
    Assignees: Sutter West Bay Hospitals, Catholic Healthcare West
    Inventor: Li-Xi Yang
  • Androsterone Derivatives and Method of Use thereof
    Publication number: 20090105202
    Abstract: The disclosure provides androsterone derivatives. The derivatives of the disclosure are useful in the treatment of androgen- and estrogen-associated diseases and disorders, including breast cancer.
    Type: Application
    Filed: October 18, 2006
    Publication date: April 23, 2009
    Applicants: CALIFORNIA PACIFIC MEDICAL CENTER, CATHOLIC HEALTHCARE WEST
    Inventor: Li-Xi Yang
  • CAMPTOTHECIN DERIVATIVES AS CHEMORADIOSENSITIZING AGENTS
    Publication number: 20080318873
    Abstract: Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
    Type: Application
    Filed: July 29, 2008
    Publication date: December 25, 2008
    Inventor: Li-Xi YANG
  • Podophyllotoxin Derivatives
    Publication number: 20080113941
    Abstract: 4-O esters of podophyllotoxin and 4?-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4?-demethylepipodophyllotoxin. The compounds are useful for treating cancer.
    Type: Application
    Filed: January 18, 2008
    Publication date: May 15, 2008
    Inventor: Li-Xi Yang
  • Podophyllotoxin derivatives
    Patent number: 7342114
    Abstract: 4-O esters of podophyllotoxin and 4?-demethylepipodophyllotoxin are provided. The compounds are 4-O esters of an alkanoic acid or substituted alkanoic acid and podophyllotoxin and 4?-demethylepipodophyllotoxin. The compounds are useful for treating cancer.
    Type: Grant
    Filed: July 1, 2003
    Date of Patent: March 11, 2008
    Assignees: California Pacific Medical Center, Catholic Healthcare West, DBA St. Mary's Medical Center
    Inventor: Li-Xi Yang
  • Camptothecin derivatives as chemoradiosensitizing agents
    Publication number: 20070093432
    Abstract: Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.
    Type: Application
    Filed: May 30, 2006
    Publication date: April 26, 2007
    Inventor: Li-Xi Yang
  • Radiosensitizing taxanes and their pharmaceutical preparations
    Patent number: 7067552
    Abstract: Taxanes containing electron-affinic radiosensitizing functional groups, their pharmaceutical preparations, and methods of making and using this new class of highly potent radiosensitizers of tumor cells.
    Type: Grant
    Filed: October 16, 2001
    Date of Patent: June 27, 2006
    Assignee: Florida State University
    Inventors: Robert A. Holton, Hossain Nadizadeh, Li-Xi Yang
  • Nitrogen-based homo-camptothecin derivatives
    Patent number: 6933302
    Abstract: (20) esters of camptothecin analogs are provided. The compounds are (20) esters of an aminoalkanoic acid or an imidoalkanoic acid and homocamptothecin, which is optionally substituted at the 7, 9, 10, 11, and 12 positions of the homocamptothecin ring. The compounds are useful for treating cancer.
    Type: Grant
    Filed: June 3, 2003
    Date of Patent: August 23, 2005
    Assignees: California Pacific Medical Center, Catholic Healthcare West
    Inventor: Li-Xi Yang
  • Camptothecin derivatives
    Patent number: RE39707
    Abstract: (20S) esters of camptothecin analogs are provided. The compounds are (20S) esters of an oxyalkanoic acid and camptothecin, which is are optionally substituted at the 7, 9, 10, 11, and 12 positions of the camptothecin ring. The compounds are useful for treating cancer.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: June 26, 2007
    Assignees: Catholic Healthcare West, California Pacific Medical Center
    Inventors: Li-Xi Yang, Xiando Pan, Huijan Wang